DE3780045D1 - Verwendung von basischen anorganischen magnesium- oder calciumsalzen zur stabilisierung von benzimidazolderivaten. - Google Patents

Verwendung von basischen anorganischen magnesium- oder calciumsalzen zur stabilisierung von benzimidazolderivaten.

Info

Publication number
DE3780045D1
DE3780045D1 DE8787301244T DE3780045T DE3780045D1 DE 3780045 D1 DE3780045 D1 DE 3780045D1 DE 8787301244 T DE8787301244 T DE 8787301244T DE 3780045 T DE3780045 T DE 3780045T DE 3780045 D1 DE3780045 D1 DE 3780045D1
Authority
DE
Germany
Prior art keywords
stabilization
calcium salts
benzimidazole derivatives
basic inorganic
inorganic magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787301244T
Other languages
English (en)
Other versions
DE3780045T2 (de
Inventor
Tadashi Makino
Tetsuro Tabata
Shin-Ichiro Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26367776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3780045(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE3780045D1 publication Critical patent/DE3780045D1/de
Application granted granted Critical
Publication of DE3780045T2 publication Critical patent/DE3780045T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787301244T 1986-02-13 1987-02-13 Verwendung von basischen anorganischen magnesium- oder calciumsalzen zur stabilisierung von benzimidazolderivaten. Expired - Lifetime DE3780045T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2956786 1986-02-13
JP3805986 1986-02-21

Publications (2)

Publication Number Publication Date
DE3780045D1 true DE3780045D1 (de) 1992-08-06
DE3780045T2 DE3780045T2 (de) 1992-12-24

Family

ID=26367776

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3750431T Expired - Lifetime DE3750431T2 (de) 1986-02-13 1987-02-13 Stabilisiertes Arzneimittel und dessen Herstellung.
DE3751845T Expired - Lifetime DE3751845T2 (de) 1986-02-13 1987-02-13 Stabilisiertes Arzneimittel und dessen Herstellung
DE8787301244T Expired - Lifetime DE3780045T2 (de) 1986-02-13 1987-02-13 Verwendung von basischen anorganischen magnesium- oder calciumsalzen zur stabilisierung von benzimidazolderivaten.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3750431T Expired - Lifetime DE3750431T2 (de) 1986-02-13 1987-02-13 Stabilisiertes Arzneimittel und dessen Herstellung.
DE3751845T Expired - Lifetime DE3751845T2 (de) 1986-02-13 1987-02-13 Stabilisiertes Arzneimittel und dessen Herstellung

Country Status (7)

Country Link
US (2) US5045321A (de)
EP (3) EP0423748B1 (de)
BG (1) BG61202B2 (de)
CA (1) CA1327010C (de)
DE (3) DE3750431T2 (de)
HK (2) HK188195A (de)
SG (1) SG50619A1 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
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US5093132A (en) 1992-03-03
EP0446961A3 (en) 1992-04-01
CA1327010C (en) 1994-02-15
DE3751845T2 (de) 1996-11-28
EP0237200B1 (de) 1992-07-01
HK1002021A1 (en) 1998-07-24
HK188195A (en) 1995-12-22
EP0237200A3 (en) 1988-02-03
SG50619A1 (en) 1998-07-20
DE3780045T2 (de) 1992-12-24
EP0446961A2 (de) 1991-09-18
EP0423748A1 (de) 1991-04-24
BG61202B2 (bg) 1997-02-28
DE3750431D1 (de) 1994-09-29
EP0237200A2 (de) 1987-09-16
DE3750431T2 (de) 1994-12-22
EP0446961B1 (de) 1996-06-19
DE3751845D1 (de) 1996-07-25
EP0423748B1 (de) 1994-08-24
US5045321A (en) 1991-09-03

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