DE3752134T2 - Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren - Google Patents

Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren

Info

Publication number
DE3752134T2
DE3752134T2 DE3752134T DE3752134T DE3752134T2 DE 3752134 T2 DE3752134 T2 DE 3752134T2 DE 3752134 T DE3752134 T DE 3752134T DE 3752134 T DE3752134 T DE 3752134T DE 3752134 T2 DE3752134 T2 DE 3752134T2
Authority
DE
Germany
Prior art keywords
expression vectors
vectors containing
eukaryotic expression
virus enhancer
enhancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3752134T
Other languages
English (en)
Other versions
DE3752134D1 (de
Inventor
Brian William Grinnel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE3752134D1 publication Critical patent/DE3752134D1/de
Application granted granted Critical
Publication of DE3752134T2 publication Critical patent/DE3752134T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3752134T 1986-04-09 1987-04-09 Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren Expired - Fee Related DE3752134T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84999986A 1986-04-09 1986-04-09

Publications (2)

Publication Number Publication Date
DE3752134D1 DE3752134D1 (de) 1997-12-04
DE3752134T2 true DE3752134T2 (de) 1998-03-19

Family

ID=25307027

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3752376T Expired - Lifetime DE3752376D1 (de) 1986-04-09 1987-04-09 Verfahren zur Anwendung den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren
DE3752382T Expired - Fee Related DE3752382T2 (de) 1986-04-09 1987-04-09 Verfahren zur Anwendung von der BK-Virus Verstärker enthaltenden eukaryotischer Expressionsvektoren
DE3752134T Expired - Fee Related DE3752134T2 (de) 1986-04-09 1987-04-09 Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3752376T Expired - Lifetime DE3752376D1 (de) 1986-04-09 1987-04-09 Verfahren zur Anwendung den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren
DE3752382T Expired - Fee Related DE3752382T2 (de) 1986-04-09 1987-04-09 Verfahren zur Anwendung von der BK-Virus Verstärker enthaltenden eukaryotischer Expressionsvektoren

Country Status (11)

Country Link
EP (3) EP0584845B1 (de)
JP (5) JP3162056B2 (de)
AU (1) AU605479B2 (de)
CA (2) CA1318619C (de)
DE (3) DE3752376D1 (de)
DK (1) DK176387A (de)
ES (3) ES2107997T3 (de)
HK (2) HK1009605A1 (de)
HU (1) HU211391B (de)
IE (3) IE81065B1 (de)
IL (5) IL98887A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613481D0 (en) * 1986-06-04 1986-07-09 Diatech Ltd Translation of mrna
CN116656627A (zh) * 2013-07-11 2023-08-29 宝生物工程株式会社 制备无包膜病毒的方法
EP3105311A1 (de) 2014-02-10 2016-12-21 Univercells NV System, vorrichtung und verfahren zur herstellung von biomolekülen
WO2016006658A1 (ja) 2014-07-10 2016-01-14 タカラバイオ株式会社 非エンベロープウイルス粒子の製造方法
EP3243904A4 (de) 2015-01-09 2018-06-27 Takara Bio Inc. Verfahren zur herstellung von unbehüllten viruspartikeln

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8327860D0 (en) * 1983-10-18 1983-11-16 Fujisawa Pharmaceutical Co Monoclonal antiprotein c antibody
JPH0789930B2 (ja) * 1984-03-08 1995-10-04 大正製薬株式会社 ウイルス性転写促進配列
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
EP0349598A1 (de) * 1987-03-13 1990-01-10 Schering Corporation Verfahren zur stimulierung der gen-expression
JPH0660120A (ja) * 1992-08-06 1994-03-04 Sharp Corp 可変長データの格納方法及び検索装置

Also Published As

Publication number Publication date
CA1340384C (fr) 1999-02-09
JPH11346789A (ja) 1999-12-21
AU605479B2 (en) 1991-01-17
DK176387D0 (da) 1987-04-07
EP0584845B1 (de) 2004-09-08
IL98886A (en) 1992-12-01
IE870912L (en) 1987-10-09
CA1318619C (en) 1993-06-01
IL82093A (en) 1992-12-01
DK176387A (da) 1987-11-13
IL82093A0 (en) 1987-10-30
JP2958286B2 (ja) 1999-10-06
DE3752134D1 (de) 1997-12-04
EP0699764A1 (de) 1996-03-06
EP0576049A1 (de) 1993-12-29
EP0584845A1 (de) 1994-03-02
JPH099980A (ja) 1997-01-14
ES2237755T3 (es) 2005-08-01
IL98887A (en) 1992-12-01
HK1021861A1 (en) 2000-07-07
HU211391B (en) 1995-11-28
IE980258A1 (en) 1987-10-09
HUT43633A (en) 1987-11-30
IL98886A0 (en) 1992-07-15
IE81065B1 (en) 2000-01-12
JP2877228B2 (ja) 1999-03-31
HK1009605A1 (en) 1999-06-04
JP2001145496A (ja) 2001-05-29
AU7117587A (en) 1987-10-15
ES2227514T3 (es) 2005-04-01
DE3752376D1 (de) 2004-10-14
ES2107997T3 (es) 1997-12-16
EP0699764B1 (de) 2005-03-09
JPS6312296A (ja) 1988-01-19
IE980257A1 (en) 1987-10-09
JP3162056B2 (ja) 2001-04-25
JPH1057081A (ja) 1998-03-03
IL98887A0 (en) 1992-07-15
DE3752382D1 (de) 2005-04-14
DE3752382T2 (de) 2005-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee