IL98887A - Method for producing a protein that is naturally gamma carboxylated - Google Patents

Method for producing a protein that is naturally gamma carboxylated

Info

Publication number
IL98887A
IL98887A IL98887A IL9888787A IL98887A IL 98887 A IL98887 A IL 98887A IL 98887 A IL98887 A IL 98887A IL 9888787 A IL9888787 A IL 9888787A IL 98887 A IL98887 A IL 98887A
Authority
IL
Israel
Prior art keywords
protein
producing
gamma carboxylated
naturally
naturally gamma
Prior art date
Application number
IL98887A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL98887A publication Critical patent/IL98887A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL98887A 1986-04-09 1987-04-02 Method for producing a protein that is naturally gamma carboxylated IL98887A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84999986A 1986-04-09 1986-04-09
IL82093A IL82093A (en) 1986-04-09 1987-04-02 Method of using eukaryotic expression vectors comprising the bk virus enhancer

Publications (1)

Publication Number Publication Date
IL98887A true IL98887A (en) 1992-12-01

Family

ID=25307027

Family Applications (5)

Application Number Title Priority Date Filing Date
IL98887A IL98887A (en) 1986-04-09 1987-04-02 Method for producing a protein that is naturally gamma carboxylated
IL82093A IL82093A (en) 1986-04-09 1987-04-02 Method of using eukaryotic expression vectors comprising the bk virus enhancer
IL98886A IL98886A (en) 1986-04-09 1987-04-02 Method for producing a functional polypeptide in a eukaryotic cell
IL98887A IL98887A0 (en) 1986-04-09 1991-07-18 A method for producing a protein that is naturally gamma carboxylated
IL98886A IL98886A0 (en) 1986-04-09 1991-07-18 Method for producing a functional polypeptide in a eukaryotic cell

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL82093A IL82093A (en) 1986-04-09 1987-04-02 Method of using eukaryotic expression vectors comprising the bk virus enhancer
IL98886A IL98886A (en) 1986-04-09 1987-04-02 Method for producing a functional polypeptide in a eukaryotic cell
IL98887A IL98887A0 (en) 1986-04-09 1991-07-18 A method for producing a protein that is naturally gamma carboxylated
IL98886A IL98886A0 (en) 1986-04-09 1991-07-18 Method for producing a functional polypeptide in a eukaryotic cell

Country Status (11)

Country Link
EP (3) EP0584845B1 (xx)
JP (5) JP3162056B2 (xx)
AU (1) AU605479B2 (xx)
CA (2) CA1318619C (xx)
DE (3) DE3752376D1 (xx)
DK (1) DK176387A (xx)
ES (3) ES2107997T3 (xx)
HK (2) HK1009605A1 (xx)
HU (1) HU211391B (xx)
IE (3) IE81065B1 (xx)
IL (5) IL98887A (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613481D0 (en) * 1986-06-04 1986-07-09 Diatech Ltd Translation of mrna
CN116656627A (zh) * 2013-07-11 2023-08-29 宝生物工程株式会社 制备无包膜病毒的方法
EP3105311A1 (en) 2014-02-10 2016-12-21 Univercells NV System, apparatus and method for biomolecules production
WO2016006658A1 (ja) 2014-07-10 2016-01-14 タカラバイオ株式会社 非エンベロープウイルス粒子の製造方法
EP3243904A4 (en) 2015-01-09 2018-06-27 Takara Bio Inc. Method for producing non-enveloped viral particles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8327860D0 (en) * 1983-10-18 1983-11-16 Fujisawa Pharmaceutical Co Monoclonal antiprotein c antibody
JPH0789930B2 (ja) * 1984-03-08 1995-10-04 大正製薬株式会社 ウイルス性転写促進配列
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
EP0349598A1 (en) * 1987-03-13 1990-01-10 Schering Corporation Method for stimulating gene expression
JPH0660120A (ja) * 1992-08-06 1994-03-04 Sharp Corp 可変長データの格納方法及び検索装置

Also Published As

Publication number Publication date
CA1340384C (fr) 1999-02-09
JPH11346789A (ja) 1999-12-21
AU605479B2 (en) 1991-01-17
DK176387D0 (da) 1987-04-07
EP0584845B1 (en) 2004-09-08
IL98886A (en) 1992-12-01
IE870912L (en) 1987-10-09
CA1318619C (en) 1993-06-01
IL82093A (en) 1992-12-01
DK176387A (da) 1987-11-13
IL82093A0 (en) 1987-10-30
JP2958286B2 (ja) 1999-10-06
DE3752134D1 (de) 1997-12-04
EP0699764A1 (en) 1996-03-06
EP0576049A1 (en) 1993-12-29
EP0584845A1 (en) 1994-03-02
JPH099980A (ja) 1997-01-14
ES2237755T3 (es) 2005-08-01
HK1021861A1 (en) 2000-07-07
DE3752134T2 (de) 1998-03-19
HU211391B (en) 1995-11-28
IE980258A1 (en) 1987-10-09
HUT43633A (en) 1987-11-30
IL98886A0 (en) 1992-07-15
IE81065B1 (en) 2000-01-12
JP2877228B2 (ja) 1999-03-31
HK1009605A1 (en) 1999-06-04
JP2001145496A (ja) 2001-05-29
AU7117587A (en) 1987-10-15
ES2227514T3 (es) 2005-04-01
DE3752376D1 (de) 2004-10-14
ES2107997T3 (es) 1997-12-16
EP0699764B1 (en) 2005-03-09
JPS6312296A (ja) 1988-01-19
IE980257A1 (en) 1987-10-09
JP3162056B2 (ja) 2001-04-25
JPH1057081A (ja) 1998-03-03
IL98887A0 (en) 1992-07-15
DE3752382D1 (de) 2005-04-14
DE3752382T2 (de) 2005-12-29

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Legal Events

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