DE3751751D1 - Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids - Google Patents

Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids

Info

Publication number
DE3751751D1
DE3751751D1 DE3751751T DE3751751T DE3751751D1 DE 3751751 D1 DE3751751 D1 DE 3751751D1 DE 3751751 T DE3751751 T DE 3751751T DE 3751751 T DE3751751 T DE 3751751T DE 3751751 D1 DE3751751 D1 DE 3751751D1
Authority
DE
Germany
Prior art keywords
amino acid
glycoprotein
immunodeficiency virus
human immunodeficiency
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751751T
Other languages
English (en)
Other versions
DE3751751T2 (de
Inventor
Paul Maddon
Dan Littman
Leonard Chess
Richard Axel
Robin Weiss
J Mcdougal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of DE3751751D1 publication Critical patent/DE3751751D1/de
Application granted granted Critical
Publication of DE3751751T2 publication Critical patent/DE3751751T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE3751751T 1986-08-21 1987-08-20 Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids Expired - Lifetime DE3751751T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89858786A 1986-08-21 1986-08-21
PCT/US1987/002050 WO1988001304A1 (en) 1986-08-21 1987-08-20 Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids

Publications (2)

Publication Number Publication Date
DE3751751D1 true DE3751751D1 (de) 1996-04-25
DE3751751T2 DE3751751T2 (de) 1996-10-17

Family

ID=25409679

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751751T Expired - Lifetime DE3751751T2 (de) 1986-08-21 1987-08-20 Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids

Country Status (9)

Country Link
US (2) US5871913A (de)
EP (1) EP0280710B1 (de)
JP (1) JP3134874B2 (de)
AT (1) ATE135747T1 (de)
AU (1) AU616639B2 (de)
CA (1) CA1340627C (de)
DE (1) DE3751751T2 (de)
DK (1) DK175520B1 (de)
WO (1) WO1988001304A1 (de)

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US5110906A (en) * 1986-08-21 1992-05-05 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
US5958678A (en) * 1986-08-21 1999-09-28 The Trustees Of Columbia University In The City Of New York DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS
US6673896B1 (en) 1986-08-21 2004-01-06 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
JP3134874B2 (ja) 1986-08-21 2001-02-13 ザ・トラステイーズ・オブ・コロンビア・ユニヴアーシテイ・イン・ザ・シテイ・オブ・ニユー・ヨーク Ｔ細胞表面タンパク質ｔ４をコードするｄｎａ並びにｔ４フラグメントのａｉｄｓ治療への使用
US5180660A (en) * 1987-02-19 1993-01-19 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
US5217895A (en) * 1987-02-19 1993-06-08 Nissin Shokuhin Kabushiki Kaisha Monoclonal anti-idiotypic antibodies specific for anti-T4 antibodies and cross-reactive with HIV
US5140105A (en) * 1987-02-19 1992-08-18 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
AU609447B2 (en) * 1987-02-19 1991-05-02 Nissin Shokuhin Kabushiki Kaisha Methods and materials for hiv detection and therapy
US5169752A (en) * 1987-02-19 1992-12-08 Nissin Shokuhin Kabushiki Kaisha Methods and materials for HIV detection
EP0344211A4 (de) * 1987-02-20 1990-03-12 Imclone Systems Inc Monoklonale antikörper in impfstofformulierungen.
IL83687A (en) * 1987-08-30 1995-03-30 Yeda Res & Dev Pharmaceutical compositions comprising molecular decays and their use in the manufacture of said compositions
JPH02501192A (ja) * 1987-09-04 1990-04-26 バイオジェン インコーポレイテッド 可溶性ｔ４蛋白を製造するためのｄｎａ配列、組換ｄｎａ分子および方法
AU618969B2 (en) * 1987-10-02 1992-01-16 Genentech Inc. Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
NZ226414A (en) * 1987-10-02 1992-07-28 Genentech Inc Cd4 peptide adhesion variants and their preparation and use
ZA887365B (en) * 1987-10-02 1990-05-30 Genentech Inc Adheson variants
IL87902A0 (en) * 1987-10-08 1989-03-31 Dana Farber Cancer Inst Inc Soluble human cd4 fragments and applications thereof
PT88783B (pt) * 1987-10-23 1993-01-29 Smithkline Beckman Corp Processo de purificacao de proteina t4 soluvel e de producao da mesma
US6004781A (en) * 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
AU3006789A (en) * 1988-02-24 1989-08-24 Smithkline Beckman Corporation Expression of hiv binding proteins
EP0346091A3 (de) * 1988-06-10 1990-09-12 Dana Farber Cancer Institute Verfahren zur Diagnose von natürlich vorkommenden Antikörpern gegen cd4
EP0378643A4 (en) * 1988-06-10 1990-12-27 Biogen, Inc. Combinations of soluble t4 proteins and anti-retroviral agents and methods for treating or preventing aids, arc and hiv infection
AU647013B2 (en) * 1988-08-22 1994-03-17 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Retroviral vectors expressing soluble CD4: a gene therapy for aids
DE3828582A1 (de) * 1988-08-23 1990-03-01 Max Planck Gesellschaft Monoklonaler antikoerper zur inhibierung der infektion von zellen durch hiv-viren
WO1990004414A1 (en) * 1988-10-18 1990-05-03 Biogen, Inc. Conjugates of soluble t4 proteins and toxins and methods for treating or preventing aids, arc and hiv infection
WO1990005534A1 (en) * 1988-11-23 1990-05-31 Genentech, Inc. Polypeptide derivatives
CA2045583A1 (en) * 1989-01-18 1990-07-19 Norman L. Letvin Compositions and methods for treating or preventing aids, arc and hiv infection
AU5437190A (en) * 1989-04-05 1990-11-05 Upjohn Company, The Soluble cd4 produced in (e. coli)
EP0408372A1 (de) * 1989-07-13 1991-01-16 Smithkline Beecham Corporation Antivirale Therapie
JPH0353894A (ja) * 1989-07-21 1991-03-07 Calpis Food Ind Co Ltd:The 抗ヒトｃｄ４ペプチドに対するモノクローナル抗体
CA2065010A1 (en) * 1989-08-23 1991-02-24 Brian Seed Non-human primate cd4 polypeptides, fusions thereof, dna encoding, and uses thereof
EP0432693A1 (de) * 1989-12-11 1991-06-19 Sumitomo Chemical Company, Limited Für virusinfizierte Zellen cytotoxische Liposomen
JPH03254693A (ja) * 1990-03-06 1991-11-13 Calpis Food Ind Co Ltd:The 抗イデオタイプ抗体作製用抗原、抗イデオタイプ抗体、及びその製法
JPH0725794B2 (ja) * 1990-03-23 1995-03-22 呉羽化学工業株式会社 新規なペプチド
WO1992013559A1 (en) * 1991-02-08 1992-08-20 Progenics Pharmaceuticals, Inc. CD4-GAMMA1 AND CD4-IgG1 CHIMERAS
US7070991B2 (en) 1991-02-08 2006-07-04 Progenics Pharmaceuticals, Inc. Cells expressing a CD4-IgG2 chimeric heterotetramer
AU660662B2 (en) 1991-02-08 1995-07-06 Progenics Pharmaceuticals, Inc. CD4-gamma2 and CD4-IgG2 chimeras
US5789152A (en) * 1991-04-30 1998-08-04 Basil T. Hone Composition and method for detecting HIV with baculovirus derived vesicles
WO1993015747A1 (en) * 1992-02-10 1993-08-19 Progenics Pharmaceuticals, Inc. A method of using cd4-containing molecules to substantially reduce the risk of occupational hiv transmission
CA2141673A1 (en) * 1992-08-07 1994-02-17 Graham P. Allaway Non-peptidyl moiety-conjugated cd4-gamma2 and cd4-igg2 immunoconjugates, and uses thereof
US5817767A (en) * 1993-02-24 1998-10-06 Progenics Pharmaceuticals, Inc. Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same
EP0830368A1 (de) 1995-06-07 1998-03-25 Genta Incorporated Auf carbamat basierende kationische lipide
US6342586B1 (en) 1996-06-10 2002-01-29 Progenics Pharmaceuticals, Inc. Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates and uses thereof
EP0900841A1 (de) * 1997-06-18 1999-03-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Spleissvarianten von LAG-3
US6908612B2 (en) 1999-10-08 2005-06-21 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US7311920B1 (en) 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US20030157063A1 (en) * 2001-12-21 2003-08-21 Jean-Louis Touraine Gene therapy using anti-gp41 antibody and CD4 immunoadhesin
CN1747970A (zh) * 2003-02-06 2006-03-15 三肽公司 抗原/抗体或配体/受体糖基化的特异性交换剂
JP4038679B2 (ja) * 2003-05-13 2008-01-30 住友電気工業株式会社 半導体レーザーバーの固定用治具
US20080146495A1 (en) * 2005-03-11 2008-06-19 The Regents Of The University Of California Methods for Treating Hiv by Inhibiting Cd4 Down-Modulation
US20130158339A1 (en) * 2011-12-16 2013-06-20 General Electric Company System and Method of Infant Care Control and Workflow
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

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US621054A (en) * 1899-03-14 Horatio frederick forrest
JPS57144983A (en) 1981-02-27 1982-09-07 Otsuka Pharmaceut Factory Inc Preparation of physiologically active substance
US4520113A (en) * 1984-04-23 1985-05-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions
US4663436A (en) * 1984-04-24 1987-05-05 Scripps Clinic And Research Foundation Leukemia-associated virus immunogen, vaccine and assay
US4761371A (en) 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US4629783A (en) * 1985-04-29 1986-12-16 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
US5126433A (en) 1986-08-21 1992-06-30 The Trustees Of Columbia University In The City Of New York Soluble forms of the t cell surface protein cd4
JP3134874B2 (ja) 1986-08-21 2001-02-13 ザ・トラステイーズ・オブ・コロンビア・ユニヴアーシテイ・イン・ザ・シテイ・オブ・ニユー・ヨーク Ｔ細胞表面タンパク質ｔ４をコードするｄｎａ並びにｔ４フラグメントのａｉｄｓ治療への使用
US5110906A (en) 1986-08-21 1992-05-05 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
JPH02501192A (ja) 1987-09-04 1990-04-26 バイオジェン インコーポレイテッド 可溶性ｔ４蛋白を製造するためのｄｎａ配列、組換ｄｎａ分子および方法
PT88783B (pt) * 1987-10-23 1993-01-29 Smithkline Beckman Corp Processo de purificacao de proteina t4 soluvel e de producao da mesma

Also Published As

Publication number Publication date
AU616639B2 (en) 1991-11-07
ATE135747T1 (de) 1996-04-15
DK217288A (da) 1988-06-16
EP0280710A4 (de) 1989-03-14
WO1988001304A1 (en) 1988-02-25
EP0280710B1 (de) 1996-03-20
CA1340627C (en) 1999-07-06
DK217288D0 (da) 1988-04-21
AU7879287A (en) 1988-03-08
DK175520B1 (da) 2004-11-22
EP0280710A1 (de) 1988-09-07
JP3134874B2 (ja) 2001-02-13
DE3751751T2 (de) 1996-10-17
US5871913A (en) 1999-02-16
JPH01500879A (ja) 1989-03-30
US6570000B1 (en) 2003-05-27

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