DE3725504A1 - Verfahren und vorrichtung zum nachweis von antikoerpern und antigenen - Google Patents
Verfahren und vorrichtung zum nachweis von antikoerpern und antigenenInfo
- Publication number
- DE3725504A1 DE3725504A1 DE19873725504 DE3725504A DE3725504A1 DE 3725504 A1 DE3725504 A1 DE 3725504A1 DE 19873725504 DE19873725504 DE 19873725504 DE 3725504 A DE3725504 A DE 3725504A DE 3725504 A1 DE3725504 A1 DE 3725504A1
- Authority
- DE
- Germany
- Prior art keywords
- carrier
- blood
- antigen
- antibody
- holder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 89
- 239000000427 antigen Substances 0.000 claims abstract description 71
- 102000036639 antigens Human genes 0.000 claims abstract description 71
- 108091007433 antigens Proteins 0.000 claims abstract description 71
- 210000004369 blood Anatomy 0.000 claims abstract description 48
- 239000008280 blood Substances 0.000 claims abstract description 48
- 238000006243 chemical reaction Methods 0.000 claims abstract description 36
- 239000000126 substance Substances 0.000 claims abstract description 33
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 25
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 24
- 210000001124 body fluid Anatomy 0.000 claims abstract description 9
- 239000010839 body fluid Substances 0.000 claims abstract description 9
- 238000012360 testing method Methods 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 25
- 210000002966 serum Anatomy 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 12
- 239000000969 carrier Substances 0.000 claims description 11
- 238000011534 incubation Methods 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 229920003023 plastic Polymers 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 229960005486 vaccine Drugs 0.000 claims description 6
- 230000000890 antigenic effect Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 4
- 239000012876 carrier material Substances 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 4
- 239000004020 conductor Substances 0.000 claims description 4
- 239000013024 dilution buffer Substances 0.000 claims description 4
- 239000012894 fetal calf serum Substances 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 241001552669 Adonis annua Species 0.000 claims description 3
- 102000003992 Peroxidases Human genes 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 3
- 229940072221 immunoglobulins Drugs 0.000 claims description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 claims description 3
- 239000002953 phosphate buffered saline Substances 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- LVSPDZAGCBEQAV-UHFFFAOYSA-N 4-chloronaphthalen-1-ol Chemical group C1=CC=C2C(O)=CC=C(Cl)C2=C1 LVSPDZAGCBEQAV-UHFFFAOYSA-N 0.000 claims description 2
- 102000014914 Carrier Proteins Human genes 0.000 claims description 2
- 108010078791 Carrier Proteins Proteins 0.000 claims description 2
- 239000007975 buffered saline Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000013610 patient sample Substances 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 238000010626 work up procedure Methods 0.000 claims description 2
- 238000004026 adhesive bonding Methods 0.000 claims 1
- 244000309466 calf Species 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 4
- 239000003550 marker Substances 0.000 abstract 1
- 238000011835 investigation Methods 0.000 description 23
- 241000725303 Human immunodeficiency virus Species 0.000 description 19
- 230000008901 benefit Effects 0.000 description 17
- 238000010790 dilution Methods 0.000 description 17
- 239000012895 dilution Substances 0.000 description 17
- 241000711798 Rabies lyssavirus Species 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 238000011161 development Methods 0.000 description 10
- 238000012216 screening Methods 0.000 description 10
- 238000002965 ELISA Methods 0.000 description 9
- 239000000020 Nitrocellulose Substances 0.000 description 8
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 8
- 229920001220 nitrocellulos Polymers 0.000 description 8
- 229940079938 nitrocellulose Drugs 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- 241000700605 Viruses Species 0.000 description 6
- 210000000056 organ Anatomy 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 206010037742 Rabies Diseases 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 208000030507 AIDS Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000003149 assay kit Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 239000011534 wash buffer Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- NWXMGUDVXFXRIG-NAOJVREFSA-N (4s,4as,5as,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2C(O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-NAOJVREFSA-N 0.000 description 1
- LJCZNYWLQZZIOS-UHFFFAOYSA-N 2,2,2-trichlorethoxycarbonyl chloride Chemical compound ClC(=O)OCC(Cl)(Cl)Cl LJCZNYWLQZZIOS-UHFFFAOYSA-N 0.000 description 1
- 208000029483 Acquired immunodeficiency Diseases 0.000 description 1
- 239000010755 BS 2869 Class G Substances 0.000 description 1
- 241001445332 Coxiella <snail> Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 206010019973 Herpes virus infection Diseases 0.000 description 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 208000004554 Leishmaniasis Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 206010029719 Nonspecific reaction Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000003602 anti-herpes Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000012550 audit Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 208000025698 brain inflammatory disease Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000003115 checkerboard titration Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- CATMPQFFVNKDEY-AAEUAGOBSA-N gamma-Glu-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 CATMPQFFVNKDEY-AAEUAGOBSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000000652 homosexual effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 description 1
- 229940116540 protein supplement Drugs 0.000 description 1
- 235000005974 protein supplement Nutrition 0.000 description 1
- 229940036105 rabies immunoglobulin Drugs 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873725504 DE3725504A1 (de) | 1987-07-31 | 1987-07-31 | Verfahren und vorrichtung zum nachweis von antikoerpern und antigenen |
EP19880907057 EP0327629A1 (de) | 1987-07-31 | 1988-07-31 | Verfahren und vorrichtung zur untersuchung von vollblut, anderen körperflüssigkeiten und sonstigen biologischen flüssigkeiten |
PCT/EP1988/000693 WO1989001156A1 (en) | 1987-07-31 | 1988-07-31 | Process and device for examining whole blood, other body fluids and other biological fluids |
AU20881/88A AU2088188A (en) | 1987-07-31 | 1988-07-31 | Process and device for examining whole blood, other body fluids and other biological fluids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873725504 DE3725504A1 (de) | 1987-07-31 | 1987-07-31 | Verfahren und vorrichtung zum nachweis von antikoerpern und antigenen |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3725504A1 true DE3725504A1 (de) | 1989-02-09 |
DE3725504C2 DE3725504C2 (enrdf_load_stackoverflow) | 1989-10-05 |
Family
ID=6332846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19873725504 Granted DE3725504A1 (de) | 1987-07-31 | 1987-07-31 | Verfahren und vorrichtung zum nachweis von antikoerpern und antigenen |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0327629A1 (enrdf_load_stackoverflow) |
AU (1) | AU2088188A (enrdf_load_stackoverflow) |
DE (1) | DE3725504A1 (enrdf_load_stackoverflow) |
WO (1) | WO1989001156A1 (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4243375C1 (de) * | 1992-12-21 | 1994-06-01 | Henning Berlin Gmbh | Bestimmungsverfahren zur Bestimmung von Antikörpern in biologischen Flüssigkeiten |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3842700A1 (de) * | 1988-12-19 | 1990-06-21 | Boehringer Mannheim Gmbh | Verfahren zur proteinimmobilisierung an einer festphase, so hergestellte protein tragende festphase sowie deren verwendung |
GB9006154D0 (en) | 1990-03-19 | 1990-05-16 | Insituform Group Ltd | Improvements relating to lining materials for pipelines and passageways and to pipes produced from such materials |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148869A (en) * | 1975-03-06 | 1979-04-10 | Baxter Travenol Laboratories, Inc. | Immunological reagent and method of using same |
EP0061541A1 (en) * | 1981-03-27 | 1982-10-06 | Biospecia Limited | Immunological analysis and a biochemical agent therefor |
DE2801026C2 (de) * | 1977-01-14 | 1983-03-03 | Kommandiittiyhtiö Finnpipette Osmo A. Suovaniemi, Helsinki | Verfahren zur photometrischen Untersuchung bei Immunbestimmungen und/oder Enzymreaktionen |
DE3320522A1 (de) * | 1982-06-08 | 1983-12-22 | Serono Diagnostics Ltd., London | Einrichtung und verfahren zur immununtersuchung |
US4452903A (en) * | 1981-02-17 | 1984-06-05 | Lee Jin P | Assay method and reagent kit means for lipid-containing body fluid |
DE3327642A1 (de) * | 1983-07-30 | 1985-02-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung eines partners einer immunreaktion sowie reagens zur durchfuehrung dieses verfahrens |
US4594327A (en) * | 1983-11-02 | 1986-06-10 | Syntex (U.S.A.) Inc. | Assay method for whole blood samples |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3579306A (en) * | 1969-01-22 | 1971-05-18 | Organon | Diagnostic test device |
US3826619A (en) * | 1971-12-21 | 1974-07-30 | Abbott Lab | Test apparatus for direct radioimmuno-assay for antigens and their antibodies |
GB1565402A (en) * | 1975-11-03 | 1980-04-23 | Int Diagnostic Tech | Diagnostic reagent holder |
JPS59155762A (ja) * | 1982-12-06 | 1984-09-04 | フイ−ルダ−・ジルレスピ−・デイビス・リミテツド | フイ−ルドイムノアツセイ反応システムおよび方法 |
CA1253070A (en) * | 1984-04-20 | 1989-04-25 | Syntex (U.S.A.), Inc. | Single step heterogenous assay |
FI860249A7 (fi) * | 1985-02-28 | 1986-08-29 | Becton Dickinson Co | Laite ja menetelmä moninkertaista, samanaikaista koetta varten. |
US4746631A (en) * | 1985-05-09 | 1988-05-24 | Ultra Diagnostics Corporation | Immunoassay method, device, and test kit |
EP0204579A3 (en) * | 1985-06-05 | 1987-10-28 | Synbiotics Corporation | Immunoassay incubation device |
DE3640412A1 (de) * | 1986-11-26 | 1988-06-09 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung einer spezifisch bindefaehigen substanz |
-
1987
- 1987-07-31 DE DE19873725504 patent/DE3725504A1/de active Granted
-
1988
- 1988-07-31 EP EP19880907057 patent/EP0327629A1/de not_active Withdrawn
- 1988-07-31 AU AU20881/88A patent/AU2088188A/en not_active Abandoned
- 1988-07-31 WO PCT/EP1988/000693 patent/WO1989001156A1/de not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148869A (en) * | 1975-03-06 | 1979-04-10 | Baxter Travenol Laboratories, Inc. | Immunological reagent and method of using same |
DE2801026C2 (de) * | 1977-01-14 | 1983-03-03 | Kommandiittiyhtiö Finnpipette Osmo A. Suovaniemi, Helsinki | Verfahren zur photometrischen Untersuchung bei Immunbestimmungen und/oder Enzymreaktionen |
US4452903A (en) * | 1981-02-17 | 1984-06-05 | Lee Jin P | Assay method and reagent kit means for lipid-containing body fluid |
EP0061541A1 (en) * | 1981-03-27 | 1982-10-06 | Biospecia Limited | Immunological analysis and a biochemical agent therefor |
DE3320522A1 (de) * | 1982-06-08 | 1983-12-22 | Serono Diagnostics Ltd., London | Einrichtung und verfahren zur immununtersuchung |
DE3327642A1 (de) * | 1983-07-30 | 1985-02-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung eines partners einer immunreaktion sowie reagens zur durchfuehrung dieses verfahrens |
US4594327A (en) * | 1983-11-02 | 1986-06-10 | Syntex (U.S.A.) Inc. | Assay method for whole blood samples |
Non-Patent Citations (4)
Title |
---|
Analytical Biochemistry, Vol.119, 1982, S.142-147 * |
Patent abstracts of Japan: 58-187862 * |
Patent abstracts of Japan: 61-260163 * |
Pharmazie heute, Bd. 3, Sept. 1980, S. 37-41 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4243375C1 (de) * | 1992-12-21 | 1994-06-01 | Henning Berlin Gmbh | Bestimmungsverfahren zur Bestimmung von Antikörpern in biologischen Flüssigkeiten |
DE4243375C2 (de) * | 1992-12-21 | 1998-04-23 | Brahms Diagnostica Gmbh | Bestimmungsverfahren zur Bestimmung von Antikörpern in biologischen Flüssigkeiten |
Also Published As
Publication number | Publication date |
---|---|
AU2088188A (en) | 1989-03-01 |
EP0327629A1 (de) | 1989-08-16 |
DE3725504C2 (enrdf_load_stackoverflow) | 1989-10-05 |
WO1989001156A1 (en) | 1989-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69931632T2 (de) | Sammelapparat für einschrittigen test von mundflüssigkeiten | |
DE69708743T2 (de) | Verfahren und Vorrichtung zur Einschrittbestimmung von Vollblut | |
DE69112610T2 (de) | Sammlung von analyten aus der mundhöhle für immunoassays. | |
DE69128618T3 (de) | Vorrichtung und verfahren zur ausführung von immunoassays | |
DE69231362T2 (de) | Gleichzeitiges testen von arzneimitteln und fingerabdrucktestverfahren | |
DE69836493T2 (de) | Vorrichtung zur bestimmung von mehreren analyten | |
EP1102988B1 (de) | Verfahren zur bestimmung der immunabwehraktivität des blutes sowie testkit hierfür | |
DE2560288C2 (de) | Probenhalter zur fluorometrischen Bestimmung von Substanzproben | |
DE212006000062U1 (de) | Vorrichtung zum Erfassen eines Analyten in einer Probe | |
DE212006000036U1 (de) | Vorrichtungen zum Probensammeln und zur Analyse | |
DE2907198C2 (enrdf_load_stackoverflow) | ||
Sebring et al. | Detection of fetal hemorrhage in Rh immune globulin candidates. A rosetting technique using enzyme‐treated Rh2Rh2 indicator erythrocytes | |
Noguchi | Serum diagnosis of syphilis and luetin reaction | |
US4315908A (en) | Method of determining human chorionic gonadotropin (HCG) in the urine | |
CN101368954A (zh) | 利用唾液进行临床或非临床检测艾滋病病毒的装置与方法 | |
Edrissian et al. | Application of enzyme-linked immunosorbent assay (ELISA) to identification of Anopheles mosquito bloodmeals | |
DE3725504C2 (enrdf_load_stackoverflow) | ||
Busey et al. | Precipitins in histoplasmosis | |
EP2646825B1 (de) | Schnelltest zum qualitativen und/oder quantitativen bestimmen von in körperflüssigkeit enthaltenen antikörpern gegen humane papillomviren sowie vorrichtung zum durchführen des schnelltests | |
DE10122806A1 (de) | Verfahren zum Nachweis von Blutzell-Antigenen und gegen diese gerichtete Antikörper | |
US20200057057A1 (en) | Methods and reagents for Toxoplasma infection diagnosis | |
DE19500862A1 (de) | Reaktionssäulen für simultane Mehrfachmessung und Verfahren zur Bestimmung von Verbindungen | |
EP2282206B1 (de) | Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner internen Kontrolle in einer grafischen Kombination | |
DE3854603T2 (de) | Teststreifen für diagnose durch multi-immunoassay system. | |
DE2555188C2 (de) | Verfahren zum Nachweis von Antigen oder Antikörper von infektiöser Hepatitis A in einer Probe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
OP8 | Request for examination as to paragraph 44 patent law | ||
8172 | Supplementary division/partition in: |
Ref country code: DE Ref document number: 3744847 Format of ref document f/p: P |
|
Q171 | Divided out to: |
Ref country code: DE Ref document number: 3744847 |
|
AH | Division in |
Ref country code: DE Ref document number: 3744847 Format of ref document f/p: P |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |