DE3721846C2 - - Google Patents

Info

Publication number

DE3721846C2

DE3721846C2 DE19873721846 DE3721846A DE3721846C2 DE 3721846 C2 DE3721846 C2 DE 3721846C2 DE 19873721846 DE19873721846 DE 19873721846 DE 3721846 A DE3721846 A DE 3721846A DE 3721846 C2 DE3721846 C2 DE 3721846C2

Authority

DE

Germany

Prior art keywords

ursodeoxycholic acid

patients

treatment

group

menthol

Prior art date

1987-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• Global Dossier
• DPMA
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• RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 30
• RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims description 28
• 229960001661 ursodiol Drugs 0.000 claims description 28
• 239000000203 mixture Substances 0.000 claims description 12
• NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 10
• 239000004575 stone Substances 0.000 claims description 10
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
• 239000004480 active ingredient Substances 0.000 claims description 5
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 235000012000 cholesterol Nutrition 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
• 150000003505 terpenes Chemical class 0.000 description 13
• 235000007586 terpenes Nutrition 0.000 description 13
• 201000001883 cholelithiasis Diseases 0.000 description 10
• 238000004090 dissolution Methods 0.000 description 7
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 6
• 208000001130 gallstones Diseases 0.000 description 6
• 229940041616 menthol Drugs 0.000 description 6
• 238000002360 preparation method Methods 0.000 description 5
• 238000002245 gallstone dissolution Methods 0.000 description 4
• 210000000941 bile Anatomy 0.000 description 3
• 230000002308 calcification Effects 0.000 description 3
• RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 3
• 230000002195 synergetic effect Effects 0.000 description 3
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
• 239000003613 bile acid Substances 0.000 description 2
• 229960001091 chenodeoxycholic acid Drugs 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 238000002604 ultrasonography Methods 0.000 description 2
• 230000001133 acceleration Effects 0.000 description 1
• 238000010306 acid treatment Methods 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000013066 combination product Substances 0.000 description 1
• 229940127555 combination product Drugs 0.000 description 1
• 238000002648 combination therapy Methods 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 238000011301 standard therapy Methods 0.000 description 1
• 239000000341 volatile oil Substances 0.000 description 1