DE3721846A1 - Mittel zur oralen litholyse von cholesteringallensteinen - Google Patents
Mittel zur oralen litholyse von cholesteringallensteinenInfo
- Publication number
- DE3721846A1 DE3721846A1 DE19873721846 DE3721846A DE3721846A1 DE 3721846 A1 DE3721846 A1 DE 3721846A1 DE 19873721846 DE19873721846 DE 19873721846 DE 3721846 A DE3721846 A DE 3721846A DE 3721846 A1 DE3721846 A1 DE 3721846A1
- Authority
- DE
- Germany
- Prior art keywords
- ursodeoxycholic acid
- litholysis
- oral
- active ingredients
- stones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004575 stone Substances 0.000 title claims description 7
- 239000003795 chemical substances by application Substances 0.000 title claims description 6
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims abstract description 17
- 229960001661 ursodiol Drugs 0.000 claims abstract description 17
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims abstract description 9
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 13
- 239000004480 active ingredient Substances 0.000 claims description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 5
- 229940041616 menthol Drugs 0.000 claims description 5
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 201000001883 cholelithiasis Diseases 0.000 abstract description 6
- 150000003505 terpenes Chemical class 0.000 description 13
- 235000007586 terpenes Nutrition 0.000 description 13
- 238000004090 dissolution Methods 0.000 description 4
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 3
- 238000002245 gallstone dissolution Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 2
- 229960001091 chenodeoxycholic acid Drugs 0.000 description 2
- 208000001130 gallstones Diseases 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873721846 DE3721846A1 (de) | 1987-06-29 | 1987-06-29 | Mittel zur oralen litholyse von cholesteringallensteinen |
| PCT/DE1988/000380 WO1989000046A1 (en) | 1987-06-29 | 1988-06-23 | Means for oral litholysis of cholesterol gallstones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873721846 DE3721846A1 (de) | 1987-06-29 | 1987-06-29 | Mittel zur oralen litholyse von cholesteringallensteinen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3721846A1 true DE3721846A1 (de) | 1989-01-12 |
| DE3721846C2 DE3721846C2 (enrdf_load_stackoverflow) | 1989-04-06 |
Family
ID=6330745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873721846 Granted DE3721846A1 (de) | 1987-06-29 | 1987-06-29 | Mittel zur oralen litholyse von cholesteringallensteinen |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE3721846A1 (enrdf_load_stackoverflow) |
| WO (1) | WO1989000046A1 (enrdf_load_stackoverflow) |
-
1987
- 1987-06-29 DE DE19873721846 patent/DE3721846A1/de active Granted
-
1988
- 1988-06-23 WO PCT/DE1988/000380 patent/WO1989000046A1/de unknown
Non-Patent Citations (9)
| Title |
|---|
| BATESON M.C. et al.: Brit.Med.J.283, (1981), S.645-646 * |
| BELL, G.D. et al.: Brit.Med.J.6, (1979), S.24 * |
| Czygan P. u.a.: Medical Tribune Kongreß- bericht 25 (1982) * |
| Doran J. et al.: GUT 20 (1979), S.312-317 * |
| ELLIS W.R. et al.: Brit.Med.J.282 (1981), S.611-612 * |
| FORTH W.: Klin.Wochenschr.63, (1985), S.1134-1136 * |
| MARIO F.D. et al.: Brit.Med.J.284, (1982), S.1047-1048 * |
| RAEDSCH R. u.a.: The Lancet 5 (1981), S.1296 * |
| Rote Liste 1977/78, Nr.28116B-28118B * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3721846C2 (enrdf_load_stackoverflow) | 1989-04-06 |
| WO1989000046A1 (en) | 1989-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: FRANCK, FERDINAND, DR., 1000 BERLIN, DE |
|
| 8339 | Ceased/non-payment of the annual fee |