DE3587214T2 - - Google Patents
Info
- Publication number
- DE3587214T2 DE3587214T2 DE85901936T DE3587214T DE3587214T2 DE 3587214 T2 DE3587214 T2 DE 3587214T2 DE 85901936 T DE85901936 T DE 85901936T DE 3587214 T DE3587214 T DE 3587214T DE 3587214 T2 DE3587214 T2 DE 3587214T2
- Authority
- DE
- Germany
- Prior art keywords
- amino acid
- acid sequence
- rotavirus
- major outer
- outer envelope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 34
- 241000702670 Rotavirus Species 0.000 claims description 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 241000617996 Human rotavirus Species 0.000 claims description 18
- 101710121417 Envelope glycoprotein Proteins 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 11
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 229960005486 vaccine Drugs 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 102100021696 Syncytin-1 Human genes 0.000 claims 7
- 241001245603 Rotavirus G2 Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 20
- 108090000288 Glycoproteins Proteins 0.000 description 18
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 17
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 13
- 102000003886 Glycoproteins Human genes 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 7
- 102100034349 Integrase Human genes 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 229940024606 amino acid Drugs 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 5
- 244000309466 calf Species 0.000 description 5
- 101150103591 Segment-8 gene Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- WRRQKFXVKRQPDB-UHFFFAOYSA-N 2-(2-aminophenyl)sulfanylaniline Chemical compound NC1=CC=CC=C1SC1=CC=CC=C1N WRRQKFXVKRQPDB-UHFFFAOYSA-N 0.000 description 3
- 239000003298 DNA probe Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000000636 Northern blotting Methods 0.000 description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 108091081021 Sense strand Proteins 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 241000702677 Simian rotavirus Species 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 108010052305 exodeoxyribonuclease III Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 229940094991 herring sperm dna Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002482 oligosaccharides Polymers 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000027419 protein insertion into membrane Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 238000011451 sequencing strategy Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPG473384 | 1984-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3587214D1 DE3587214D1 (en) | 1993-04-29 |
| DE3587214T2 true DE3587214T2 (enExample) | 1993-07-01 |
Family
ID=3770594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585901936T Expired - Lifetime DE3587214D1 (en) | 1984-04-27 | 1985-04-29 | Rotavirus. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5395759A (enExample) |
| EP (1) | EP0180603B1 (enExample) |
| JP (1) | JPS61501958A (enExample) |
| AU (1) | AU591058B2 (enExample) |
| CA (1) | CA1339735C (enExample) |
| DE (1) | DE3587214D1 (enExample) |
| WO (1) | WO1985005122A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339735C (en) * | 1984-04-27 | 1998-03-17 | Ian Hamilton Holmes. | Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus |
| DE3505148A1 (de) * | 1985-02-15 | 1986-10-30 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele |
| US5763269A (en) * | 1985-09-06 | 1998-06-09 | Syntro Corporation | Recombinant infectious bovine rhinotrocheitis virus |
| US5068192A (en) * | 1986-01-27 | 1991-11-26 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence |
| US6086880A (en) * | 1985-12-26 | 2000-07-11 | The University Of Saskatchewan | Rotavirus peptide compositions and methods of use |
| EP0235391B1 (en) * | 1985-12-26 | 1992-06-10 | The University of Saskatchewan | Peptides corresponding to antigenic and immunogenic determinants of major neutralizing proteins of rotaviruses |
| WO1987004463A1 (en) * | 1986-01-27 | 1987-07-30 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
| US5593873A (en) * | 1986-01-27 | 1997-01-14 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
| CA1331355C (en) * | 1986-04-21 | 1994-08-09 | Bioenterprises Pty. Ltd | Immunopotentation |
| EP0251467A3 (en) * | 1986-06-20 | 1988-07-20 | Abbott Laboratories | Compositions and methods of use for a major outer capsid protein (vp7) of rotavirus sa-11 |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US5186933A (en) * | 1986-12-30 | 1993-02-16 | Baylor College Of Medicine | Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system |
| JP3055687B2 (ja) * | 1987-08-10 | 2000-06-26 | ザ ユニバーシティー オブ メルボルン | Ｖｐ７をコードするヒトロタウイルス血清型４遺伝子９の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのｖｐ７及びそのフラグメントの発現 |
| WO1989006971A1 (en) * | 1988-02-01 | 1989-08-10 | The Board Of Trustees Of The Leland Stanford Junio | Conserved rotavirus gene segments and use in immunization and neutralization |
| CA2113641A1 (en) * | 1991-07-18 | 1993-02-04 | Mark D. Cochran | Recombinant infectious bovine rhinotracheitis virus |
| JP4776832B2 (ja) * | 2000-10-19 | 2011-09-21 | キヤノン株式会社 | 座標入力装置、および、画像入力装置の座標板 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1678783A (en) * | 1982-07-20 | 1984-01-26 | Molecular Genetics, Inc. | Production of herpes simplex viral proteins |
| DK305784A (da) * | 1983-06-23 | 1984-12-24 | Stanley Person | Ikke-glycosyleret aminosyrekaede af glycoprotein b fra herpes virus type 1 og 2 |
| US4571385A (en) * | 1983-06-27 | 1986-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Genetic reassortment of rotaviruses for production of vaccines and vaccine precursors |
| AU585494B2 (en) * | 1984-02-09 | 1989-06-22 | Royal Children's Hospital Research Foundation | Live attenuated human rotavirus vaccine and preparation thereof |
| CA1339735C (en) * | 1984-04-27 | 1998-03-17 | Ian Hamilton Holmes. | Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus |
| AU5736286A (en) * | 1985-05-14 | 1986-11-20 | Commonwealth Scientific And Industrial Research Organisation | Rotavirus antigens |
| ATE469320T1 (de) * | 2000-11-10 | 2010-06-15 | Cunningham John | Universalstütze und schwingungsisolator |
-
1985
- 1985-04-26 CA CA000480251A patent/CA1339735C/en not_active Expired - Fee Related
- 1985-04-29 DE DE8585901936T patent/DE3587214D1/de not_active Expired - Lifetime
- 1985-04-29 AU AU42970/85A patent/AU591058B2/en not_active Expired
- 1985-04-29 WO PCT/AU1985/000096 patent/WO1985005122A1/en not_active Ceased
- 1985-04-29 EP EP85901936A patent/EP0180603B1/en not_active Expired - Lifetime
- 1985-04-29 JP JP60502036A patent/JPS61501958A/ja active Pending
- 1985-04-29 US US07/474,642 patent/US5395759A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 US US08/202,380 patent/US5741698A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5741698A (en) | 1998-04-21 |
| EP0180603B1 (en) | 1993-03-24 |
| DE3587214D1 (en) | 1993-04-29 |
| CA1339735C (en) | 1998-03-17 |
| AU591058B2 (en) | 1989-11-30 |
| EP0180603A1 (en) | 1986-05-14 |
| WO1985005122A1 (en) | 1985-11-21 |
| AU4297085A (en) | 1985-11-28 |
| JPS61501958A (ja) | 1986-09-11 |
| EP0180603A4 (en) | 1988-03-22 |
| US5395759A (en) | 1995-03-07 |
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| DE3587214T2 (enExample) | ||
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |