DE3567470D1 - Copolymer and method for producing the same - Google Patents

Copolymer and method for producing the same

Info

Publication number
DE3567470D1
DE3567470D1 DE8585304733T DE3567470T DE3567470D1 DE 3567470 D1 DE3567470 D1 DE 3567470D1 DE 8585304733 T DE8585304733 T DE 8585304733T DE 3567470 T DE3567470 T DE 3567470T DE 3567470 D1 DE3567470 D1 DE 3567470D1
Authority
DE
Germany
Prior art keywords
copolymer
producing
same
weight
dispersity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585304733T
Other languages
English (en)
Inventor
Motoaki Tanaka
Yasuaki Ogawa
Tsutomu Miyagawa
Toshio Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15266918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3567470(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP59140356A external-priority patent/JPH0678425B2/ja
Application filed by Wako Pure Chemical Industries Ltd, Takeda Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Application granted granted Critical
Publication of DE3567470D1 publication Critical patent/DE3567470D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
DE8585304733T 1984-07-06 1985-07-03 Copolymer and method for producing the same Expired DE3567470D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59140356A JPH0678425B2 (ja) 1984-07-06 1984-07-06 重合体の新規製造法

Publications (1)

Publication Number Publication Date
DE3567470D1 true DE3567470D1 (en) 1989-02-16

Family

ID=15266918

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585304734T Expired DE3567471D1 (en) 1984-07-06 1985-07-03 Method for producing a polymer or copolymer of lactic acid and/or glycolic acid
DE8585304733T Expired DE3567470D1 (en) 1984-07-06 1985-07-03 Copolymer and method for producing the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585304734T Expired DE3567471D1 (en) 1984-07-06 1985-07-03 Method for producing a polymer or copolymer of lactic acid and/or glycolic acid

Country Status (8)

Country Link
US (2) US4683288A (de)
EP (2) EP0171907B2 (de)
AT (2) ATE39936T1 (de)
BG (1) BG61520B2 (de)
CA (2) CA1236641A (de)
DE (2) DE3567471D1 (de)
HK (1) HK19592A (de)
SG (1) SG108191G (de)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
GB8609537D0 (en) * 1986-04-18 1986-05-21 Ici Plc Polyesters
DE3720806C2 (de) * 1986-07-03 1997-08-21 Clariant Finance Bvi Ltd Verwendung eines Stabilisators in Peroxydbleichverfahren
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
AU634723B2 (en) * 1988-08-08 1993-03-04 Biopak Technology, Ltd. Degradable thermoplastic from lactides
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
BR8907604A (pt) * 1988-08-08 1991-07-30 Battelle Memorial Institute Composicao ambientalmente biodegradavel,processo para produzir a mesma e processo para tornar uma composicao de polimero termoplastico ambientalmente biodegradavel
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
DE4005415C2 (de) * 1990-02-21 1996-04-11 Boehringer Ingelheim Kg Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
NO302481B1 (no) 1990-10-16 1998-03-09 Takeda Chemical Industries Ltd Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5294469A (en) * 1992-06-17 1994-03-15 Mitsui Toatsu Chemicals, Incorporated Industrial woven fabric and composite sheet comprising same
US5758053A (en) * 1992-07-22 1998-05-26 Hitachi, Ltd. Fault handling and recovery for system having plural processors
WO1994008078A1 (en) * 1992-10-02 1994-04-14 Cargill, Incorporated A melt-stable lactide polymer fabric and process for manufacture thereof
AU5296393A (en) * 1992-10-02 1994-04-26 Cargill Incorporated Paper having a melt-stable lactide polymer coating and process for manufacture thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
US5643595A (en) * 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ATE288270T1 (de) * 1993-11-19 2005-02-15 Janssen Pharmaceutica Nv Mikroverkapselte 1,2-benzazole
EP0789045B1 (de) * 1995-08-29 2001-01-10 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von polyhydroxycarbonsäure
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
WO1997031049A1 (fr) * 1996-02-23 1997-08-28 Kyowa Hakko Kogyo Co., Ltd. Procede d'elaboration d'acide polyhydroxycarboxylique
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) * 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
ATE293652T1 (de) * 1999-12-10 2005-05-15 Equipolymers Gmbh Katalysatorsysteme für polykondensationsreaktionen
US6960626B2 (en) * 2000-01-21 2005-11-01 Cyclics Corporation Intimate physical mixtures containing macrocyclic polyester oligomer and filler
ES2577389T3 (es) * 2000-08-07 2016-07-14 Wako Pure Chemical Industries, Ltd. Polímero de ácido láctico y procedimiento para su producción
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
DE60135759D1 (de) * 2000-08-16 2008-10-23 Tyco Healthcare Absorbierendes polymerharz mit hoher konsistenz
US7767781B2 (en) 2000-09-01 2010-08-03 Cyclics Corporation Preparation of low-acid polyalkylene terephthalate and preparation of macrocyclic polyester oligomer therefrom
US7750109B2 (en) 2000-09-01 2010-07-06 Cyclics Corporation Use of a residual oligomer recyclate in the production of macrocyclic polyester oligomer
AU2002324447B2 (en) 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
US7071291B2 (en) 2001-06-27 2006-07-04 Cyclics Corporation Isolation, formulation and shaping of macrocyclic oligoesters
AR034641A1 (es) * 2001-06-29 2004-03-03 Takeda Pharmaceutical Composicion de liberacion controlada y metodo para producirla
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US6849600B2 (en) * 2002-03-25 2005-02-01 The Regents Of The University Of California, Berkeley Corticotropin-releasing hormone analogs
WO2004029129A1 (ja) * 2002-09-24 2004-04-08 Asahi Kasei Chemicals Corporation グリコール酸共重合体及びその製造方法
EP1440992A1 (de) * 2003-01-21 2004-07-28 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Katalysatorzusammensetzung für die (Co)polymerisation von Lactid und Glycolid
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
CA2533314C (en) 2003-07-18 2013-07-09 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US20080318837A1 (en) * 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
US20060210614A1 (en) * 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
DE112005000965T5 (de) * 2004-04-28 2007-03-22 Keio University Depolymerisationsverfahren für Polymere mit Esterbindung in der Hauptkette und Verfahren zur Herstellung von Polymeren mit Esterbindung in der Hauptkette aus dem Depolymerisationsprodukt
EP1761178B1 (de) * 2004-05-21 2010-12-08 Micro Therapeutics, Inc. Mit biologischen oder biologisch abbaubaren oder synthetischen polymeren oder fasern umschlungene metallspulen zur embolisierung einer körperhöhle
US20070254314A1 (en) * 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
WO2006032291A1 (de) 2004-09-22 2006-03-30 Dendron Gmbh Vorrichtung zur implantation von mikrowendeln
DE102005019782A1 (de) * 2005-04-28 2006-11-09 Dendron Gmbh Vorrichtung zur Implantation von Okklusionswendeln mit innenliegendem Sicherungsmittel
EP1716847B1 (de) * 2005-04-28 2008-01-02 Nipro Corporation Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
WO2007067964A2 (en) * 2005-12-08 2007-06-14 Nastech Pharmaceutical Company Inc. Mucosal delivery of stabilized formulations of exendin
EP3029461B1 (de) 2006-11-01 2017-12-20 Ventana Medical Systems, Inc. Haptene, haptenkonjugate, zusammensetzungen daraus und verfahren für ihre herstellung und verwendung
TWI481424B (zh) 2006-12-18 2015-04-21 Takeda Pharmaceutical 緩釋性組成物及其製法
KR20100015520A (ko) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 코일과 펴짐방지 부재를 포함하는 임플란트
WO2010009451A2 (en) 2008-07-17 2010-01-21 Merial Limited Long-acting injectable analgesic formulations for animals
WO2010047674A1 (en) 2008-10-20 2010-04-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Low molecular weight thyroid stimulating hormone receptor (tshr) agonists
CA2740970A1 (en) 2008-10-21 2010-04-29 Oregon Health & Science University Naphthamides as anticancer agents
CN101445595B (zh) * 2008-12-26 2011-01-19 上海新上化高分子材料有限公司 聚乙丙交酯及其制备方法和应用
US9365612B2 (en) 2010-01-29 2016-06-14 United States Of America As Represented By The Secretary, Department Of Health And Human Services Caspase inhibitors
WO2011127388A2 (en) 2010-04-08 2011-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inverse agonists and neutral antagonists for the tsh receptor
WO2012125486A1 (en) 2011-03-11 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination chemotherapy for treating cancer
EP2685985B1 (de) 2011-03-17 2016-08-31 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Verfahren zur behandlung von leukämie und erkrankungen durch cbf- und runx1-proteine
CN102295765B (zh) * 2011-06-30 2012-11-28 南京大学 生物质肌酐催化共缩聚法合成聚乳酸-乙醇酸
CN102329269B (zh) * 2011-06-30 2013-07-17 南京大学 仿生氯化肌酐胍催化缩聚法合成高分子量聚乳酸
WO2013039792A1 (en) 2011-09-12 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunogens based on an hiv-1 gp120 v1v2 epitope
US20140234360A1 (en) 2011-09-30 2014-08-21 The United States of America, as represented by the Secretary, Dept.of Health and Human Services Influenza vaccine
EP2802565A4 (de) 2012-01-13 2015-07-08 Univ Oregon Health & Science Verbindungen, zusammensetzungen und zugehörige verfahren mit 3-aryl-chinolinen
PL2858975T3 (pl) 2012-06-08 2019-10-31 Univ Pittsburgh Commonwealth Sys Higher Education Inhibitory fbxo3
WO2014078309A1 (en) 2012-11-13 2014-05-22 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Cannabinoid receptor mediating compounds
WO2014093702A1 (en) 2012-12-12 2014-06-19 The Usa, As Represented By The Secretary, Department Of Health And Human Services Hiv therapeutics and methods of making and using same
EP2996691A1 (de) 2013-05-16 2016-03-23 The U.S.A. as represented by the Secretary, Department of Health and Human Services Verbindungen zur hemmung medikamentenresistenter stämme der hiv-1-integrase
JP6564380B2 (ja) 2013-09-20 2019-08-21 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 前立腺癌を治療するための化合物
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
CA2948349C (en) 2014-05-09 2023-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
CA2959347C (en) 2014-08-25 2023-03-07 Salk Institute For Biological Studies Ulk1 inhibitors and methods using same
US10400015B2 (en) 2014-09-04 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant HIV-1 envelope proteins and their use
WO2016064716A1 (en) 2014-10-20 2016-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapy of tshr antagonist and igfr inhibitor
WO2016103238A1 (en) 2014-12-24 2016-06-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant metapneumovirus f proteins and their use
US10196372B2 (en) 2015-01-05 2019-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services MYC G-quadruplex stabilizing small molecules and their use
SG11201706729SA (en) 2015-02-20 2017-09-28 Univ Oregon Health & Science Derivatives of sobetirome
US20180273485A1 (en) 2015-06-04 2018-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Cannabinoid receptor mediating compounds
US10799580B2 (en) 2015-09-09 2020-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Expression vector delivery system and use thereof for inducing an immune response
WO2017151802A1 (en) 2016-03-04 2017-09-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor mediating compounds
SI3457851T1 (sl) 2016-05-18 2022-04-29 Oregon Health & Science University Derivati sobetiroma
US20190255079A1 (en) 2016-06-16 2019-08-22 Acies Bio D.O.O. Compositions and methods useful for treating diseases characterized by insufficient pantothenate kinase activity
WO2018109220A2 (en) 2016-12-16 2018-06-21 Institute For Research In Biomedicine Novel recombinant prefusion rsv f proteins and uses thereof
WO2019046748A1 (en) 2017-08-31 2019-03-07 Evonik Corporation ENHANCED RESORBABLE POLYMER PURIFICATION METHOD
WO2019118803A1 (en) 2017-12-14 2019-06-20 The United States Of America, As Represented By The Secretary,Department Of Health And Human Services Chemical entities for lytic activation of kshv and therapeutic targeting of viral enzymes/proteins
BR112020018832A2 (pt) 2018-03-29 2021-02-09 Elex Biotech, Inc. compostos para o tratamento de arritimias cardíacas e insuficiência cardíaca
JP2022502378A (ja) 2018-09-25 2022-01-11 ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 2’−ハロゲン化−4’−チオ−2’−デオキシ−5−アザシチジンアナログおよびその使用
JP2022513449A (ja) 2018-12-12 2022-02-08 オートバーン セラピューティクス,インク. 新規な甲状腺模倣物
CA3130371A1 (en) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Novel thyromimetics
WO2020185695A1 (en) 2019-03-11 2020-09-17 Oregon State University Analogues and derivatives of cephalotaxine and methods for making and using the compounds
CA3222837A1 (en) 2021-06-09 2022-12-15 John S. Schneekloth Compounds that bind non-canonical g-quadruplex structures and methods of making and using the same
WO2023059867A1 (en) 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for treating or preventing alzheimer's disease
WO2023146771A1 (en) 2022-01-25 2023-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gingerenone a prodrugs as senotherapeutics and methods of use
WO2023177568A1 (en) 2022-03-14 2023-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor modulating compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1995970A (en) * 1931-04-04 1935-03-26 Du Pont Polymeric lactide resin
US2362511A (en) * 1939-11-21 1944-11-14 Du Pont Modified glycolide resins
US2438208A (en) * 1943-07-10 1948-03-23 Us Agriculture Continuous process of converting lactic acid to polylactic acid
US2683136A (en) * 1950-10-25 1954-07-06 Du Pont Copolymers of hydroxyacetic acid with other alcohol acids
US2703316A (en) * 1951-06-05 1955-03-01 Du Pont Polymers of high melting lactide
US2758987A (en) * 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3531561A (en) * 1965-04-20 1970-09-29 Ethicon Inc Suture preparation
US3498957A (en) * 1965-09-14 1970-03-03 Ethicon Inc Polymerization of cyclic carboxylic esters in the presense of a nonpolymerizable ester plasticizer
US3468853A (en) * 1966-06-15 1969-09-23 American Cyanamid Co Process of polymerizing a glycolide
BE758156R (fr) * 1970-05-13 1971-04-28 Ethicon Inc Element de suture absorbable et sa
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions

Also Published As

Publication number Publication date
EP0172636B1 (de) 1989-01-11
DE3567471D1 (en) 1989-02-16
EP0171907B1 (de) 1989-01-11
EP0171907B2 (de) 1994-08-10
EP0172636B2 (de) 1992-11-11
CA1236641A (en) 1988-05-10
US4683288A (en) 1987-07-28
US4677191A (en) 1987-06-30
EP0172636A1 (de) 1986-02-26
SG108191G (en) 1992-06-12
ATE39935T1 (de) 1989-01-15
BG61520B2 (bg) 1997-10-31
ATE39936T1 (de) 1989-01-15
EP0171907A1 (de) 1986-02-19
HK19592A (en) 1992-03-20
CA1256638A (en) 1989-06-27

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