DE3477844D1 - Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances - Google Patents

Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances

Info

Publication number
DE3477844D1
DE3477844D1 DE8484305286T DE3477844T DE3477844D1 DE 3477844 D1 DE3477844 D1 DE 3477844D1 DE 8484305286 T DE8484305286 T DE 8484305286T DE 3477844 T DE3477844 T DE 3477844T DE 3477844 D1 DE3477844 D1 DE 3477844D1
Authority
DE
Germany
Prior art keywords
active substances
reagents
stabilizing
preparation
insoluble carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484305286T
Other languages
German (de)
English (en)
Inventor
Yoshitsugu Sakata
Yoshitaka Hamaguchi
Motoo Goto
Shinzo Kobatake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15356567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3477844(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Application granted granted Critical
Publication of DE3477844D1 publication Critical patent/DE3477844D1/de
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8484305286T 1983-08-05 1984-08-03 Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances Expired DE3477844D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58144201A JPS6035263A (ja) 1983-08-05 1983-08-05 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬

Publications (1)

Publication Number Publication Date
DE3477844D1 true DE3477844D1 (en) 1989-05-24

Family

ID=15356567

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484305286T Expired DE3477844D1 (en) 1983-08-05 1984-08-03 Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances

Country Status (4)

Country Link
EP (1) EP0140489B1 (OSRAM)
JP (1) JPS6035263A (OSRAM)
AT (1) ATE42410T1 (OSRAM)
DE (1) DE3477844D1 (OSRAM)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2187191B (en) * 1984-01-30 1989-11-01 Quadrant Bioresources Ltd Protection of proteins and the like
WO1987000196A1 (en) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection of proteins and the like
GB8500698D0 (en) * 1985-01-11 1985-02-13 Unilever Plc Preparation of reagents
JPS61241665A (ja) * 1985-04-18 1986-10-27 Toyobo Co Ltd 安定化された固相試薬
JPS6234059A (ja) * 1985-08-07 1987-02-14 Sankyo Co Ltd 固相化試薬の安定化剤
JPS62170850A (ja) * 1986-01-23 1987-07-27 Wako Pure Chem Ind Ltd 免疫化学的測定法
US5514602A (en) * 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
ES2150428T3 (es) 1987-04-27 2000-12-01 Unilever Nv Ensayos de union especifica.
FR2616915B1 (fr) * 1987-06-16 1989-09-29 Ire Medgenix Sa Solution d'une substance de nature polypeptidique, et utilisation pour des dosages immunologiques
GB8716826D0 (en) * 1987-07-16 1987-08-19 Tills D Protection of proteinaceous reagents
GB8801338D0 (en) * 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5262296A (en) * 1988-03-30 1993-11-16 Toray Industries, Inc. Freeze-dried composition containing enzyme-labeled anti-human interferon-β antibody and enzyme immunoassay kit containing the composition
DE3811659C1 (OSRAM) * 1988-04-07 1989-11-16 Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US5077198A (en) * 1988-04-14 1991-12-31 Eastman Kodak Company Diagnostic kit and method for rapid detection of antibodies
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells
US5192663A (en) * 1988-11-04 1993-03-09 Immucor, Inc. Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
AU609332B2 (en) * 1988-11-09 1991-04-26 Biotrack, Inc. Method and composition of stabilizing and solubilizing latex reagents
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
JPH02161357A (ja) * 1988-12-15 1990-06-21 Tosoh Corp 免疫測定用材料の安定化方法
FR2645967B1 (fr) * 1989-04-12 1994-04-01 Diagnostica Stago Procede d'adsorption d'un materiel immunologique, utilisation dans le domaine des reactions antigene/anticorps
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
USRE38385E1 (en) 1989-02-16 2004-01-13 Nektar Therapeutics Storage of materials
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
DE3919393A1 (de) * 1989-06-14 1990-12-20 Hoechst Ag Verfahren zur stabilisierung von auf festphasen immobilisierten biologisch aktiven substanzen
CA1340565C (en) 1989-06-29 1999-05-25 Thomas B. Okarma Device and process for cell capture and recovery
US6143508A (en) * 1989-06-29 2000-11-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Device and process for cell capture and recovery
AU633981B2 (en) * 1989-10-12 1993-02-11 Takeda Chemical Industries Ltd. Antigen-sensitized bead and use thereof
US5252496A (en) * 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label
CA2053299A1 (en) * 1990-02-28 1991-08-29 Marvin A. Motsenbocker Immunoassay
JPH0565233A (ja) * 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
DE69230828T2 (de) * 1991-10-11 2000-10-12 Abbott Laboratories, Abbott Park Gebrauchsfertige Reagenszusammensetzungseinheiten für einen spezifischen Bindungstest.
JP3167415B2 (ja) * 1992-04-30 2001-05-21 オリンパス光学工業株式会社 固相免疫検査における抗原細胞の保存方法
GB9211176D0 (en) * 1992-05-27 1992-07-08 Central Blood Lab Authority Assay
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
NZ257212A (en) 1992-09-29 1996-11-26 Inhale Therapeutic Syst Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone
BR9507023A (pt) 1994-03-07 1997-09-23 Inhale Therapeutic Syst Processos para aerossolização de uma dose de insulina para a liberação respiratória de insulina e para preparação de uma composição de insulina e composição de insulina
BE1008221A3 (fr) * 1994-03-28 1996-02-20 Anda Biolog Sa Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention.
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
US6979576B1 (en) 1997-07-25 2005-12-27 Shu-Ching Cheng Methods of use of one step immunochromatographic device for Streptococcus A antigen
EP0988552B1 (en) * 1997-06-10 2010-11-24 Lpath, Inc. Methods for early detection of heart disease
IL121116A (en) * 1997-06-19 2000-12-06 Savyon Diagnostics Ltd Stabilization of polypeptides for use in immunoassay procedures
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
FR2777355B1 (fr) * 1998-04-10 2000-05-12 Bio Merieux Procede de fixation d'une molecule biologique sur la surface d'un support constitue de silice ou d'oxyde metallique
MXPA02001323A (es) 2000-05-10 2004-07-16 Alliance Pharma Microgranulos con base fosfolipida para la liberacion de farmaco.
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
ATE508735T1 (de) 2001-12-19 2011-05-15 Novartis Ag Pulmonale verabreichung von aminoglykosiden
US6927062B2 (en) 2002-11-25 2005-08-09 Agdia, Inc. Controls and standards for assays and method for manufacture thereof
CA2653454A1 (en) * 2006-05-23 2007-11-29 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
JP5349838B2 (ja) 2007-11-30 2013-11-20 和光純薬工業株式会社 ｓｍａｌｌＲＮＡの取得用担体、取得方法及び取得用試薬
JP2010014685A (ja) * 2008-07-04 2010-01-21 Bio Matrix Research Inc タンパク質安定化溶液
JP5832723B2 (ja) * 2009-03-06 2015-12-16 協和メデックス株式会社 可溶性インターロイキン−２受容体定量用標準品
EP2230515B1 (en) 2009-03-16 2014-12-17 Agilent Technologies, Inc. Passivation of surfaces after ligand coupling
CN107002072A (zh) 2014-12-05 2017-08-01 和光纯药工业株式会社 Tim蛋白质结合载体、使用该载体的细胞外膜囊泡及病毒的取得方法、除去方法、检测方法、以及包括该载体的试剂盒
JP6449221B2 (ja) * 2016-03-24 2019-01-09 三洋化成工業株式会社 粒子組成物、免疫測定用試薬及び免疫測定方法
WO2018194134A1 (ja) * 2017-04-20 2018-10-25 株式会社シノテスト 抗ペリオスチン抗体固定化担体、ペリオスチン測定試薬、及び抗ペリオスチン抗体固定化担体における抗体の安定化方法
JP7269906B2 (ja) * 2019-10-29 2023-05-09 三洋化成工業株式会社 免疫測定用試薬、免疫測定用キット及び免疫測定方法
JP7425092B2 (ja) 2020-01-15 2024-01-30 富士フイルム株式会社 抗線維化剤、及び抗線維化作用を有する細胞外小胞の製造方法
EP4091671A4 (en) 2020-01-15 2023-07-05 FUJIFILM Corporation ANGIOGENIC AGENT AND METHOD FOR PRODUCING EXTRACELLULAR VESICLES WITH AN ANGIOGENIC EFFECT
CN115697359A (zh) 2020-01-15 2023-02-03 富士胶片株式会社 抗炎剂及具有抗炎作用的细胞外囊泡的制造方法
AU2023414368A1 (en) 2022-12-28 2025-07-10 Fujifilm Corporation Porous carrier, method for aquiring extracellular vesicle, method for producing extracellular vesicle, and kit
WO2025012398A1 (en) 2023-07-11 2025-01-16 Olink Proteomics Ab Dried reagents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4921052A (OSRAM) * 1972-06-16 1974-02-25
JPS5423118A (en) * 1977-07-25 1979-02-21 Kitasato Inst Vaccine for bibrio disease of bred fish
GB2016687B (en) * 1978-03-20 1982-09-08 Abbott Lab Sugar coated reagents for solid phase immunoassay
GB2107053A (en) * 1980-06-20 1983-04-20 Unilever Plc Processes and apparatus for carrying out specific binding assays
JPS57103649A (en) * 1980-12-18 1982-06-28 Asahi Chemical Ind Sterilized gamma-globulin fixing column
EP0063810B1 (en) * 1981-04-29 1986-03-05 Ciba-Geigy Ag New devices and kits for immunological analysis
JPS57182168A (en) * 1981-05-02 1982-11-09 Mitsubishi Chem Ind Ltd Immunochemical reagent
GB2124231B (en) * 1982-05-24 1985-10-02 Corning Glass Works Solid phase reagent for immunoassay

Also Published As

Publication number Publication date
EP0140489A1 (en) 1985-05-08
EP0140489B1 (en) 1989-04-19
ATE42410T1 (de) 1989-05-15
JPS6035263A (ja) 1985-02-23
JPH0541946B2 (OSRAM) 1993-06-25

Similar Documents

Publication Publication Date Title
DE3477844D1 (en) Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances
DE3160110D1 (en) Interference-resistant composition, device, method of preparing it and method for determining a peroxidatively active substance in a test sample
AU510807B2 (en) Test device and method for determining blood hemoglobin
DK285488A (da) Peptid, praeparat indeholdende peptidet og proevemetode, hvor peptidet anvendes
FI873215A7 (fi) Menetelmä ja laite sähkökemiallisesti aktiivisten komponenttien määrittämiseksi
FI881704A7 (fi) Menetelmä ja laite analyyttitason määrittämiseksi kokoverinäytteestä.
EP0351659A3 (en) Method and arrangement for measuring the concentration of optically active substances
NO171282C (no) Fremgangsmaate for bestemmelse av mikrobekonsentrasjoner med en smelteagarmetode, samt deri anvendte skaaler
IT8448540A0 (it) Proteine umane, antisieri per esse, procedimento per prepararli e corredi di prova che li contengono
JPS57129697A (en) Method and tester for measuring glucose concentration
FI861269A7 (fi) Menetelmä ja testauslaite analyyttien määrittämiseksi.
EP0313095A3 (en) Method for preparing hydroxysilanes and/or their oligomers
ATE100938T1 (de) Verfahren zur bestimmung der thyroxinbindekapazitaet und dazu geeignete standardloesung.
ZA892702B (en) Process for the determination of thyroxine and a suitable standard solution therefor
IL88278A (en) Method for the preparation of a homogeneous aqueous test solution for electrolyte test and a homogeneous solution for measuring the concentration of an ion in an aqueous test sample
ATE78604T1 (de) Verwendung von polyvinylpyrrolidon (pvp) zur truebungsminderung von seren, seren enthaltend pvp und verfahren zu deren herstellung.
IL106634A0 (en) Method and standard solution for the determination of thyroxine(t4)or triiodothyronine(t3)
JPS6438658A (en) Solid phase antibody for immunoassay
IL85597A0 (en) Method and test composition for an enzyme immunoassay
EP0273754A3 (en) Method of enhancing the biodistribution of antibody for localization in lesions
JPS649366A (en) Immunological method, reagent and kit for measuring protein c
IL93112A0 (en) Method for preparing devices useful for determining the presence of an analyte in a test solution
DE59000474D1 (de) Einrichtung zur strahlmodulation im strahlengang photometrischer analysatoren.
BG35820A1 (en) Carrier for immobilizing biological active substances and method for preparing them
ZA884088B (en) Animal derived cell with antigenic protein introduced therein

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation