DE3477844D1 - Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances - Google Patents
Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substancesInfo
- Publication number
- DE3477844D1 DE3477844D1 DE8484305286T DE3477844T DE3477844D1 DE 3477844 D1 DE3477844 D1 DE 3477844D1 DE 8484305286 T DE8484305286 T DE 8484305286T DE 3477844 T DE3477844 T DE 3477844T DE 3477844 D1 DE3477844 D1 DE 3477844D1
- Authority
- DE
- Germany
- Prior art keywords
- active substances
- reagents
- stabilizing
- preparation
- insoluble carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58144201A JPS6035263A (ja) | 1983-08-05 | 1983-08-05 | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3477844D1 true DE3477844D1 (en) | 1989-05-24 |
Family
ID=15356567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484305286T Expired DE3477844D1 (en) | 1983-08-05 | 1984-08-03 | Method for stabilizing immunologically active substances immobilized on an insoluble carrier and their use in the preparation of reagents for measuring physiologically active substances |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0140489B1 (de) |
JP (1) | JPS6035263A (de) |
AT (1) | ATE42410T1 (de) |
DE (1) | DE3477844D1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2187191B (en) * | 1984-01-30 | 1989-11-01 | Quadrant Bioresources Ltd | Protection of proteins and the like |
GB8500698D0 (en) * | 1985-01-11 | 1985-02-13 | Unilever Plc | Preparation of reagents |
JPS61241665A (ja) * | 1985-04-18 | 1986-10-27 | Toyobo Co Ltd | 安定化された固相試薬 |
EP0229810B1 (de) * | 1985-07-09 | 1991-10-16 | Quadrant Bioresources Limited | Beschützung von proteinen und ähnlichem |
JPS6234059A (ja) * | 1985-08-07 | 1987-02-14 | Sankyo Co Ltd | 固相化試薬の安定化剤 |
JPS62170850A (ja) * | 1986-01-23 | 1987-07-27 | Wako Pure Chem Ind Ltd | 免疫化学的測定法 |
US5514602A (en) * | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
EP0291194B8 (de) | 1987-04-27 | 2003-10-22 | Inverness Medical Switzerland GmbH | Immunoassays und Vorrichtungen dafür |
FR2616915B1 (fr) * | 1987-06-16 | 1989-09-29 | Ire Medgenix Sa | Solution d'une substance de nature polypeptidique, et utilisation pour des dosages immunologiques |
GB8716826D0 (en) * | 1987-07-16 | 1987-08-19 | Tills D | Protection of proteinaceous reagents |
GB8801338D0 (en) * | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
US5262296A (en) * | 1988-03-30 | 1993-11-16 | Toray Industries, Inc. | Freeze-dried composition containing enzyme-labeled anti-human interferon-β antibody and enzyme immunoassay kit containing the composition |
DE3811659C1 (de) * | 1988-04-07 | 1989-11-16 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De | |
US5077198A (en) * | 1988-04-14 | 1991-12-31 | Eastman Kodak Company | Diagnostic kit and method for rapid detection of antibodies |
US5759774A (en) * | 1988-05-18 | 1998-06-02 | Cobe Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells |
US5192663A (en) * | 1988-11-04 | 1993-03-09 | Immucor, Inc. | Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article |
US5030560A (en) * | 1988-11-04 | 1991-07-09 | Immucor, Inc. | Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same |
AU609332B2 (en) * | 1988-11-09 | 1991-04-26 | Biotrack, Inc. | Method and composition of stabilizing and solubilizing latex reagents |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
JPH02161357A (ja) * | 1988-12-15 | 1990-06-21 | Tosoh Corp | 免疫測定用材料の安定化方法 |
FR2645967B1 (fr) * | 1989-04-12 | 1994-04-01 | Diagnostica Stago | Procede d'adsorption d'un materiel immunologique, utilisation dans le domaine des reactions antigene/anticorps |
GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
USRE39497E1 (en) | 1989-02-16 | 2007-02-27 | Nektar Therapeutics | Storage of materials |
US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
DE3919393A1 (de) * | 1989-06-14 | 1990-12-20 | Hoechst Ag | Verfahren zur stabilisierung von auf festphasen immobilisierten biologisch aktiven substanzen |
US6143508A (en) * | 1989-06-29 | 2000-11-07 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Device and process for cell capture and recovery |
CA1340565C (en) * | 1989-06-29 | 1999-05-25 | Thomas B. Okarma | Device and process for cell capture and recovery |
AU633981B2 (en) * | 1989-10-12 | 1993-02-11 | Takeda Chemical Industries Ltd. | Antigen-sensitized bead and use thereof |
US5252496A (en) * | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
EP0473787A1 (de) * | 1990-02-28 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Verbesserter Immunoanalyse |
JPH0565233A (ja) * | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
AU659645B2 (en) | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
DE69230828T2 (de) * | 1991-10-11 | 2000-10-12 | Abbott Laboratories, Abbott Park | Gebrauchsfertige Reagenszusammensetzungseinheiten für einen spezifischen Bindungstest. |
JP3167415B2 (ja) * | 1992-04-30 | 2001-05-21 | オリンパス光学工業株式会社 | 固相免疫検査における抗原細胞の保存方法 |
GB9211176D0 (en) * | 1992-05-27 | 1992-07-08 | Central Blood Lab Authority | Assay |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
CZ295827B6 (cs) | 1994-03-07 | 2005-11-16 | Nektar Therapeutics | Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití |
BE1008221A3 (fr) * | 1994-03-28 | 1996-02-20 | Anda Biolog Sa | Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention. |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
US6979576B1 (en) | 1997-07-25 | 2005-12-27 | Shu-Ching Cheng | Methods of use of one step immunochromatographic device for Streptococcus A antigen |
US6210976B1 (en) * | 1997-06-10 | 2001-04-03 | Medlyte Diagnostics, Inc. | Methods for early detection of heart disease |
IL121116A (en) * | 1997-06-19 | 2000-12-06 | Savyon Diagnostics Ltd | Stabilization of polypeptides for use in immunoassay procedures |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
FR2777355B1 (fr) * | 1998-04-10 | 2000-05-12 | Bio Merieux | Procede de fixation d'une molecule biologique sur la surface d'un support constitue de silice ou d'oxyde metallique |
US7442388B2 (en) | 2000-05-10 | 2008-10-28 | Weers Jeffry G | Phospholipid-based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
ES2180416B1 (es) | 2001-03-12 | 2004-06-01 | BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. | Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen. |
SI1458360T1 (sl) | 2001-12-19 | 2011-08-31 | Novartis Ag | Pulmonalno dajanje aminoglikozidov |
US6927062B2 (en) | 2002-11-25 | 2005-08-09 | Agdia, Inc. | Controls and standards for assays and method for manufacture thereof |
EP2210955A3 (de) * | 2006-05-23 | 2010-09-15 | Molecular Detection, Inc. | Bei Umgebungstemperatur beständige Kits zur Molekulardiagnostik |
JP5349838B2 (ja) | 2007-11-30 | 2013-11-20 | 和光純薬工業株式会社 | smallRNAの取得用担体、取得方法及び取得用試薬 |
JP2010014685A (ja) * | 2008-07-04 | 2010-01-21 | Bio Matrix Research Inc | タンパク質安定化溶液 |
JP5832723B2 (ja) * | 2009-03-06 | 2015-12-16 | 協和メデックス株式会社 | 可溶性インターロイキン−2受容体定量用標準品 |
EP2230515B1 (de) * | 2009-03-16 | 2014-12-17 | Agilent Technologies, Inc. | Passivierung von Oberflächen nach Ligandenkupplung |
CN113980089A (zh) | 2014-12-05 | 2022-01-28 | 富士胶片和光纯药株式会社 | 一种检测试样中的细胞外膜囊泡的方法和检测用试剂盒的用途 |
JP6449221B2 (ja) * | 2016-03-24 | 2019-01-09 | 三洋化成工業株式会社 | 粒子組成物、免疫測定用試薬及び免疫測定方法 |
JPWO2018194134A1 (ja) * | 2017-04-20 | 2020-02-27 | 株式会社シノテスト | 抗ペリオスチン抗体固定化担体、ペリオスチン測定試薬、及び抗ペリオスチン抗体固定化担体における抗体の安定化方法 |
JP7269906B2 (ja) * | 2019-10-29 | 2023-05-09 | 三洋化成工業株式会社 | 免疫測定用試薬、免疫測定用キット及び免疫測定方法 |
EP4091617A4 (de) | 2020-01-15 | 2023-08-09 | FUJIFILM Corporation | Antifibrotisches mittel und verfahren zum produzieren extrazellulärer vesikel, die eine antifibrotische wirkung aufweisen |
JP7461382B2 (ja) | 2020-01-15 | 2024-04-03 | 富士フイルム株式会社 | 抗炎症剤、及び抗炎症作用を有する細胞外小胞の製造方法 |
JPWO2021145396A1 (de) | 2020-01-15 | 2021-07-22 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4921052A (de) * | 1972-06-16 | 1974-02-25 | ||
JPS5423118A (en) * | 1977-07-25 | 1979-02-21 | Kitasato Inst | Vaccine for bibrio disease of bred fish |
GB2016687B (en) * | 1978-03-20 | 1982-09-08 | Abbott Lab | Sugar coated reagents for solid phase immunoassay |
WO1982000058A1 (en) * | 1980-06-20 | 1982-01-07 | Porter P | Processes and apparatus for carrying out specific binding assays |
JPS57103649A (en) * | 1980-12-18 | 1982-06-28 | Asahi Chemical Ind | Sterilized gamma-globulin fixing column |
AR231590A1 (es) * | 1981-04-29 | 1984-12-28 | Ciba Geigy Ag | Dispositivo de analisis inmunologico y procedimiento para obtenerlo |
JPS57182168A (en) * | 1981-05-02 | 1982-11-09 | Mitsubishi Chem Ind Ltd | Immunochemical reagent |
GB2124231B (en) * | 1982-05-24 | 1985-10-02 | Corning Glass Works | Solid phase reagent for immunoassay |
-
1983
- 1983-08-05 JP JP58144201A patent/JPS6035263A/ja active Granted
-
1984
- 1984-08-03 EP EP84305286A patent/EP0140489B1/de not_active Expired
- 1984-08-03 AT AT84305286T patent/ATE42410T1/de not_active IP Right Cessation
- 1984-08-03 DE DE8484305286T patent/DE3477844D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0140489A1 (de) | 1985-05-08 |
JPH0541946B2 (de) | 1993-06-25 |
ATE42410T1 (de) | 1989-05-15 |
EP0140489B1 (de) | 1989-04-19 |
JPS6035263A (ja) | 1985-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8331 | Complete revocation |