DE3421735C2 - - Google Patents
Info
- Publication number
- DE3421735C2 DE3421735C2 DE19843421735 DE3421735A DE3421735C2 DE 3421735 C2 DE3421735 C2 DE 3421735C2 DE 19843421735 DE19843421735 DE 19843421735 DE 3421735 A DE3421735 A DE 3421735A DE 3421735 C2 DE3421735 C2 DE 3421735C2
- Authority
- DE
- Germany
- Prior art keywords
- embedding
- hydrolysis
- acetylsalicylic acid
- tablets
- suppositories
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 9
- 230000007062 hydrolysis Effects 0.000 claims description 9
- 238000006460 hydrolysis reaction Methods 0.000 claims description 9
- 239000000829 suppository Substances 0.000 claims description 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 6
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 6
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 6
- 229960002622 triacetin Drugs 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000012188 paraffin wax Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 239000000155 melt Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229940116364 hard fat Drugs 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 239000010695 polyglycol Substances 0.000 description 2
- 229920000151 polyglycol Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 2
- 229940066675 ricinoleate Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 1
- 241001559547 Hippocampus comes Species 0.000 description 1
- 244000046127 Sorghum vulgare var. technicum Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- -1 fatty acid propylene glycol ester Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843421735 DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843421735 DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3421735A1 DE3421735A1 (de) | 1985-12-12 |
| DE3421735C2 true DE3421735C2 (en, 2012) | 1989-11-16 |
Family
ID=6238145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843421735 Granted DE3421735A1 (de) | 1984-06-12 | 1984-06-12 | Einbettungsmasse fuer hydrolyseempfindliche arzneimittelwirkstoffe |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3421735A1 (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK8603837A (en, 2012) * | 1985-08-13 | 1987-02-14 | ||
| US4765978A (en) * | 1986-12-16 | 1988-08-23 | Schering Corporation | Novel vaginal suppository |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2439538C3 (de) * | 1974-08-17 | 1980-07-17 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | Verfahren zur Herstellung von oral zu verabreichenden Arzneimitteln mit verzögerter Wirkungsfreigabe |
| DE2551446B2 (de) * | 1975-11-15 | 1977-09-15 | Karl Werner Schlüter GmbH, 2000 Ham burg | Verfahren zur herstellung von suppositorien |
| JPS5391113A (en) * | 1977-01-21 | 1978-08-10 | Meiji Seika Kaisha Ltd | Preparation of suppository of antibiotics |
-
1984
- 1984-06-12 DE DE19843421735 patent/DE3421735A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3421735A1 (de) | 1985-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2224534C3 (de) | Pharmazeutisches Präparat mit langsamer Wirkstoffabgabe | |
| DE69427589T2 (de) | Neue zusammensetzung | |
| EP0959876B1 (de) | Verfahren zur trennung von wirkstoffen in festen pharmazeutischen zubereitungen | |
| DE1492208A1 (de) | Tablettenherstellungsverfahren | |
| DE1130556B (de) | Verfahren zur Herstellung von Antimalariapraeparaten | |
| DE2332484A1 (de) | Lutschpastillen mit verzoegerter freigabe | |
| DE2951077C2 (en, 2012) | ||
| DE2135025A1 (de) | Keimarmes, fhessfähiges Pankreatm präparat und ein Verfahren zu dessen Herstellung | |
| DE68914683T2 (de) | Arzneimittelzusammensetzung für die schnelle verabreichung des aktiven bestandteils, der aus einer festen dispersion und einem oberflächenaktiven mittel besteht. | |
| CH622677A5 (en, 2012) | ||
| DE3421735C2 (en, 2012) | ||
| EP0108882A1 (de) | Presslinge mit retardierter Wirkstofffreisetzung und Verfahren zu deren Herstellung | |
| EP0073428B1 (de) | Neue Arzneimittelpräparation für Glykosidhydrolasen-Inhibitoren | |
| EP0615450B1 (de) | Dimeticon-pastillen | |
| DE3142853C2 (en, 2012) | ||
| DE3878169T2 (de) | Medizinische zusammensetzungen, gegruendet auf flavonoiden und saponinen, gewonnen aus chrysanthellum, verfahren zu ihrer herstellung und therapeutische anwendungen. | |
| EP0186090A2 (de) | Verfahren zur Herstellung von Ascorbinsäure-Granulat | |
| DE2115116A1 (de) | Verbesserte Gleitmittel und Ver fahren zur Herstellung derselben | |
| DE68902657T3 (de) | Verfahren zur Herstellung von festem Sorbit. | |
| DE2638088C3 (de) | Verwendung von SuBmolkenpulver | |
| DE3442065A1 (de) | Nifedipin-zusammensetzung und verfahren zu ihrer herstellung | |
| WO2000030605A2 (de) | Verfahren zur herstellung von arzneimitteln in fester darreichungsform aus pflanzlichen extrakten | |
| DE2148391A1 (de) | Arzneimittel mit verlängerter Wirk stoffabgabe | |
| DE2949216C2 (de) | Verfahren zur Herstellung von wasserfreier stabiler Lactose | |
| DE938566C (de) | Verfahren zur Herstellung von lager- und zerfallfaehigen Arzneimitteltabletten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8125 | Change of the main classification |
Ipc: A61K 31/60 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |