DE3348153C2 - - Google Patents
Info
- Publication number
- DE3348153C2 DE3348153C2 DE3348153A DE3348153A DE3348153C2 DE 3348153 C2 DE3348153 C2 DE 3348153C2 DE 3348153 A DE3348153 A DE 3348153A DE 3348153 A DE3348153 A DE 3348153A DE 3348153 C2 DE3348153 C2 DE 3348153C2
- Authority
- DE
- Germany
- Prior art keywords
- citric acid
- papain
- patient
- administration
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 26
- 108090000526 Papain Proteins 0.000 claims description 17
- 239000004365 Protease Substances 0.000 claims description 17
- 229940055729 papain Drugs 0.000 claims description 17
- 235000019834 papain Nutrition 0.000 claims description 17
- 206010012601 diabetes mellitus Diseases 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 210000002700 urine Anatomy 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 230000036449 good health Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 235000012149 noodles Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000013618 yogurt Nutrition 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 240000006432 Carica papaya Species 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- 241001634499 Cola Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000021147 sweet food Nutrition 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57091794A JPS58208235A (ja) | 1982-05-29 | 1982-05-29 | 循環器系疾病治療剤 |
| JP57124237A JPS5913733A (ja) | 1982-07-15 | 1982-07-15 | 循環器系疫病治療効果を有する飲食品 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3348153A1 DE3348153A1 (en, 2012) | 1987-05-27 |
| DE3348153C2 true DE3348153C2 (en, 2012) | 1988-02-11 |
Family
ID=26433232
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3348153A Expired DE3348153C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348162A Expired DE3348162C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348163A Expired DE3348163C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348165A Expired DE3348165C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348164A Expired DE3348164C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE19833319575 Granted DE3319575A1 (de) | 1982-05-29 | 1983-05-30 | Therapeutisch wirksame zusammensetzungen, nahrungsmittel und getraenke |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3348162A Expired DE3348162C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348163A Expired DE3348163C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348165A Expired DE3348165C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE3348164A Expired DE3348164C2 (en, 2012) | 1982-05-29 | 1983-05-30 | |
| DE19833319575 Granted DE3319575A1 (de) | 1982-05-29 | 1983-05-30 | Therapeutisch wirksame zusammensetzungen, nahrungsmittel und getraenke |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4477434A (en, 2012) |
| DE (6) | DE3348153C2 (en, 2012) |
| FR (1) | FR2527446B1 (en, 2012) |
| GB (1) | GB2122488B (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112611A (en) * | 1990-09-10 | 1992-05-12 | Floss Products Corporation | Pharmaceutical compositions for aiding human digestion |
| US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
| US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
| US7985404B1 (en) | 1999-07-27 | 2011-07-26 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
| US7309688B2 (en) * | 2000-10-27 | 2007-12-18 | Johnson & Johnson Consumer Companies | Topical anti-cancer compositions and methods of use thereof |
| BRPI0006503B1 (pt) * | 2000-02-04 | 2017-05-09 | Biolab Sanus Farmacêutica Ltda | composição em forma de gel, creme, aerosol, spray, líquida e liofilizada de substância carreadora de produtos à base de papaína |
| US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
| US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
| CA2443018A1 (en) * | 2001-04-06 | 2002-10-17 | Cristiano Alberto Ribeiro Santana | Papaine containing pharmaceutical formulation resp. its use |
| JP2006104080A (ja) * | 2004-10-01 | 2006-04-20 | Cross:Kk | 痛風と尿酸による血流障害の予防又は治療効果のある組成物及び健康食品。 |
| DE502007004835D1 (de) * | 2006-05-09 | 2010-10-07 | Infors Ag | Schüttelvorrichtung |
| EP2321640B1 (en) | 2008-08-21 | 2016-11-30 | Immunogenics LLC | Formulation for oral administration of proteins |
| US20130089641A1 (en) * | 2011-10-11 | 2013-04-11 | Sunway Biotech Co., Ltd. | Soymilk with Additive of Vitamin C, Vitamin C salt or Vitamin C Stereoisomer |
| EP3479894B1 (de) | 2017-11-02 | 2022-04-20 | Infors AG | Schüttler |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB808300A (en) * | 1955-12-28 | 1959-02-04 | Schwarz Lab Inc | Improvements in a soluble enzyme preparation and process of recovery of the same |
| CH558659A (fr) * | 1969-11-26 | 1975-02-14 | Orsymonde | Procede pour la preparation d'une composition lyophilisee a usage hygienique. |
| GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| NL7908722A (nl) * | 1979-12-03 | 1981-07-01 | Naarden International Nv | Werkwijze voor de bereiding van citrussap bevattende dranken met verbeterde troebelingsstabiliteit. |
-
1983
- 1983-05-23 US US06/497,029 patent/US4477434A/en not_active Expired - Lifetime
- 1983-05-26 GB GB08314542A patent/GB2122488B/en not_active Expired
- 1983-05-30 DE DE3348153A patent/DE3348153C2/de not_active Expired
- 1983-05-30 DE DE3348162A patent/DE3348162C2/de not_active Expired
- 1983-05-30 DE DE3348163A patent/DE3348163C2/de not_active Expired
- 1983-05-30 DE DE3348165A patent/DE3348165C2/de not_active Expired
- 1983-05-30 DE DE3348164A patent/DE3348164C2/de not_active Expired
- 1983-05-30 FR FR8308899A patent/FR2527446B1/fr not_active Expired
- 1983-05-30 DE DE19833319575 patent/DE3319575A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3319575A1 (de) | 1983-12-01 |
| DE3348162C2 (en, 2012) | 1988-02-04 |
| GB2122488A (en) | 1984-01-18 |
| DE3348163C2 (en, 2012) | 1988-02-04 |
| US4477434A (en) | 1984-10-16 |
| FR2527446B1 (fr) | 1987-01-30 |
| GB2122488B (en) | 1985-09-18 |
| DE3348153A1 (en, 2012) | 1987-05-27 |
| DE3319575C2 (en, 2012) | 1988-02-04 |
| DE3348164C2 (en, 2012) | 1988-02-04 |
| FR2527446A1 (fr) | 1983-12-02 |
| GB8314542D0 (en) | 1983-06-29 |
| DE3348165C2 (en, 2012) | 1988-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| Q172 | Divided out of (supplement): |
Ref country code: DE Ref document number: 3319575 |
|
| 8181 | Inventor (new situation) |
Free format text: ERFINDER IST ANMELDER |
|
| 8110 | Request for examination paragraph 44 | ||
| AC | Divided out of |
Ref country code: DE Ref document number: 3319575 Format of ref document f/p: P |
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| AC | Divided out of |
Ref country code: DE Ref document number: 3319575 Format of ref document f/p: P |
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| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN |