DE3233424A1 - Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung - Google Patents

Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Info

Publication number
DE3233424A1
DE3233424A1 DE19823233424 DE3233424A DE3233424A1 DE 3233424 A1 DE3233424 A1 DE 3233424A1 DE 19823233424 DE19823233424 DE 19823233424 DE 3233424 A DE3233424 A DE 3233424A DE 3233424 A1 DE3233424 A1 DE 3233424A1
Authority
DE
Germany
Prior art keywords
isoquinoline
hydrogen
formula
carboxylic acid
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823233424
Other languages
German (de)
English (en)
Inventor
Joachim Dr. 6000 Frankfurt Kaiser
Elmar Dr. 6233 Kelkheim Konz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19823233424 priority Critical patent/DE3233424A1/de
Priority to EP83108697A priority patent/EP0105210B1/de
Priority to DE8383108697T priority patent/DE3369983D1/de
Priority to AT83108697T priority patent/ATE25679T1/de
Priority to KR1019830004199A priority patent/KR840006206A/ko
Priority to GR72399A priority patent/GR79382B/el
Priority to NZ205513A priority patent/NZ205513A/en
Priority to ES525441A priority patent/ES525441A0/es
Priority to US06/530,000 priority patent/US4673682A/en
Priority to IL69683A priority patent/IL69683A0/xx
Priority to FI833200A priority patent/FI833200A7/fi
Priority to PH29505A priority patent/PH18186A/en
Priority to PT77309A priority patent/PT77309B/pt
Priority to NO833217A priority patent/NO833217L/no
Priority to AU18916/83A priority patent/AU1891683A/en
Priority to CA000436316A priority patent/CA1211445A/en
Priority to ZA836663A priority patent/ZA836663B/xx
Priority to JP58164274A priority patent/JPS5967270A/ja
Priority to DK408083A priority patent/DK408083A/da
Priority to HU833134A priority patent/HU191094B/hu
Publication of DE3233424A1 publication Critical patent/DE3233424A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19823233424 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung Withdrawn DE3233424A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE19823233424 DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
EP83108697A EP0105210B1 (de) 1982-09-09 1983-09-03 Isochinolinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen und ihre Verwendung
DE8383108697T DE3369983D1 (en) 1982-09-09 1983-09-03 Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use
AT83108697T ATE25679T1 (de) 1982-09-09 1983-09-03 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.
KR1019830004199A KR840006206A (ko) 1982-09-09 1983-09-07 이소퀴놀린 유도체의 제조방법
GR72399A GR79382B (cg-RX-API-DMAC10.html) 1982-09-09 1983-09-07
NZ205513A NZ205513A (en) 1982-09-09 1983-09-07 Isoquinoline-4-carboxylic acid derivatives and pharmaceutical compositions containing such
ES525441A ES525441A0 (es) 1982-09-09 1983-09-07 Procedimiento para preparar derivados de acidos isoquinolein-4-carboxilicos
US06/530,000 US4673682A (en) 1982-09-09 1983-09-07 Isoquinoline derivatives, pharmaceutical formulations based on these compounds and the use thereof
IL69683A IL69683A0 (en) 1982-09-09 1983-09-07 Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof
FI833200A FI833200A7 (fi) 1982-09-09 1983-09-07 Isokinolinderivat, foerfaranden foer deras framstaellning, pao dessa foereningar baserade farmaceutpreparat och deras anvaendning
PH29505A PH18186A (en) 1982-09-09 1983-09-07 Isoquinoline derivatives,a process for their preparation pharmaceutical formulations based on these compounds and the use thereof
PT77309A PT77309B (de) 1982-09-09 1983-09-08 Isochinolinderivate verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
NO833217A NO833217L (no) 1982-09-09 1983-09-08 Isokinolinderivater, fremgangsmaate til deres fremstilling, farmasoeytiske preparater paa basis av disse forbindelser og deres anvendelse
AU18916/83A AU1891683A (en) 1982-09-09 1983-09-08 Substituted 1-phenyl-isoquinoline anti-arrythmic agents
CA000436316A CA1211445A (en) 1982-09-09 1983-09-08 Isoquinoline derivatives, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof
ZA836663A ZA836663B (en) 1982-09-09 1983-09-08 Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof
JP58164274A JPS5967270A (ja) 1982-09-09 1983-09-08 イソキノリン誘導体の製法
DK408083A DK408083A (da) 1982-09-09 1983-09-08 Isoquinolinderivater, deres fremstilling og anvendelse
HU833134A HU191094B (en) 1982-09-09 1983-09-08 Process for producing insoquinoline derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823233424 DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Publications (1)

Publication Number Publication Date
DE3233424A1 true DE3233424A1 (de) 1984-03-15

Family

ID=6172780

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19823233424 Withdrawn DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DE8383108697T Expired DE3369983D1 (en) 1982-09-09 1983-09-03 Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8383108697T Expired DE3369983D1 (en) 1982-09-09 1983-09-03 Isoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Country Status (19)

Country Link
US (1) US4673682A (cg-RX-API-DMAC10.html)
EP (1) EP0105210B1 (cg-RX-API-DMAC10.html)
JP (1) JPS5967270A (cg-RX-API-DMAC10.html)
KR (1) KR840006206A (cg-RX-API-DMAC10.html)
AT (1) ATE25679T1 (cg-RX-API-DMAC10.html)
AU (1) AU1891683A (cg-RX-API-DMAC10.html)
CA (1) CA1211445A (cg-RX-API-DMAC10.html)
DE (2) DE3233424A1 (cg-RX-API-DMAC10.html)
DK (1) DK408083A (cg-RX-API-DMAC10.html)
ES (1) ES525441A0 (cg-RX-API-DMAC10.html)
FI (1) FI833200A7 (cg-RX-API-DMAC10.html)
GR (1) GR79382B (cg-RX-API-DMAC10.html)
HU (1) HU191094B (cg-RX-API-DMAC10.html)
IL (1) IL69683A0 (cg-RX-API-DMAC10.html)
NO (1) NO833217L (cg-RX-API-DMAC10.html)
NZ (1) NZ205513A (cg-RX-API-DMAC10.html)
PH (1) PH18186A (cg-RX-API-DMAC10.html)
PT (1) PT77309B (cg-RX-API-DMAC10.html)
ZA (1) ZA836663B (cg-RX-API-DMAC10.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
EP0590455B1 (en) * 1992-09-28 2000-12-27 Hoechst Aktiengesellschaft Antiarrhythmic and cardioprotective substituted 1(2H)-isoquinolines, process for their production, medicament containing them and their use for the production of a medicament for combating heart failures
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
CA2528232C (en) 2003-06-06 2010-05-25 Fibrogen, Inc. Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
EP2044028B1 (en) 2006-01-27 2012-05-16 Fibrogen, Inc. Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
KR101084635B1 (ko) * 2006-04-04 2011-11-18 피브로겐, 인크. Ｈｉｆ 조절제로서 피롤로- 및 티아졸로-피리딘 화합물
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
JP6129217B2 (ja) 2012-03-09 2017-05-17 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼインヒビターとしての４−ヒドロキシ−イソキノリン化合物
ES2905898T3 (es) 2012-07-16 2022-04-12 Fibrogen Inc Formas cristalinas de un inhibidor de prolil hidroxilasa
MY171483A (en) 2012-07-16 2019-10-15 Fibrogen Inc Process for making isoquinoline compounds
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
KR102233081B1 (ko) 2013-01-24 2021-03-29 피브로겐, 인크. 〔[1-시아노-5-(4-클로로페녹시)-4-하이드록시-아이소퀴놀린-3-카보닐]-아미노〕-아세트산의 결정 형태

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054482B1 (cg-RX-API-DMAC10.html) * 1969-07-11 1973-06-08 Anvar
FR2424270A1 (fr) * 1978-04-24 1979-11-23 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES8404852A1 (es) 1984-05-16
DK408083D0 (da) 1983-09-08
ATE25679T1 (de) 1987-03-15
EP0105210B1 (de) 1987-03-04
GR79382B (cg-RX-API-DMAC10.html) 1984-10-22
NO833217L (no) 1984-03-12
PT77309A (de) 1983-10-01
ES525441A0 (es) 1984-05-16
IL69683A0 (en) 1983-12-30
JPS5967270A (ja) 1984-04-16
FI833200A7 (fi) 1984-03-10
NZ205513A (en) 1986-05-09
HU191094B (en) 1987-01-28
PH18186A (en) 1985-04-12
EP0105210A2 (de) 1984-04-11
FI833200A0 (fi) 1983-09-07
DE3369983D1 (en) 1987-04-09
EP0105210A3 (en) 1984-10-10
ZA836663B (en) 1984-04-25
PT77309B (de) 1986-04-18
DK408083A (da) 1984-03-10
US4673682A (en) 1987-06-16
KR840006206A (ko) 1984-11-22
CA1211445A (en) 1986-09-16
AU1891683A (en) 1984-03-15

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee