ZA836663B - Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof - Google Patents

Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof

Info

Publication number
ZA836663B
ZA836663B ZA836663A ZA836663A ZA836663B ZA 836663 B ZA836663 B ZA 836663B ZA 836663 A ZA836663 A ZA 836663A ZA 836663 A ZA836663 A ZA 836663A ZA 836663 B ZA836663 B ZA 836663B
Authority
ZA
South Africa
Prior art keywords
compounds
preparation
pharmaceutical formulations
formulations based
isoquinoline derivatives
Prior art date
Application number
ZA836663A
Other languages
English (en)
Inventor
Elmar Konz
Joachim Kaiser
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA836663B publication Critical patent/ZA836663B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
ZA836663A 1982-09-09 1983-09-08 Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof ZA836663B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823233424 DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA836663B true ZA836663B (en) 1984-04-25

Family

ID=6172780

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA836663A ZA836663B (en) 1982-09-09 1983-09-08 Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof

Country Status (19)

Country Link
US (1) US4673682A (xx)
EP (1) EP0105210B1 (xx)
JP (1) JPS5967270A (xx)
KR (1) KR840006206A (xx)
AT (1) ATE25679T1 (xx)
AU (1) AU1891683A (xx)
CA (1) CA1211445A (xx)
DE (2) DE3233424A1 (xx)
DK (1) DK408083A (xx)
ES (1) ES8404852A1 (xx)
FI (1) FI833200A (xx)
GR (1) GR79382B (xx)
HU (1) HU191094B (xx)
IL (1) IL69683A0 (xx)
NO (1) NO833217L (xx)
NZ (1) NZ205513A (xx)
PH (1) PH18186A (xx)
PT (1) PT77309B (xx)
ZA (1) ZA836663B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
DE69329787T2 (de) * 1992-09-28 2001-06-13 Hoechst Ag Antiarrhythmische und cardioprotektive substituierte 1(2H)-Isochinoline, Verfahren zu deren Herstellung, diese enthaltende Arzneimittel und ihre Anwendung für die Herstellung eines Arzneimittels zur Behandlung von Herzinsuffizienzen
JP2006527200A (ja) 2003-06-06 2006-11-30 ファイブロゲン インコーポレイティッド 窒素含有ヘテロアリール化合物および内因性エリトロポエチンを増加させる際のそれらの使用方法
RU2457204C2 (ru) 2006-01-27 2012-07-27 Файброджен, Инк. Цианоизохинолиновые соединения (варианты), фармацевтическая композиция на их основе, способ ингибирования активности гидроксилазы гипоксия-индуцибельного фактора (hif) и способ лечения и/или профилактики состояния, связанного с hif, и/или состояния, связанного с эритропоэтином, и/или анемии
AU2007234408B2 (en) * 2006-04-04 2011-05-19 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
NZ592741A (en) 2008-11-14 2013-03-28 Fibrogen Inc Thiochromene derivatives as hif hydroxylase inhibitors
EP2834220B1 (en) 2012-03-09 2016-11-09 Fibrogen, Inc. 4-hydroxy-isoquinoline compounds as hif hydroxylase inhibitors
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
WO2014014834A1 (en) 2012-07-16 2014-01-23 Fibrogen, Inc. Process for making isoquinoline compounds
HUE041458T2 (hu) 2012-07-16 2019-05-28 Fibrogen Inc Prolil-hidroxiláz inhibitor kristályos alakjai
KR102233081B1 (ko) 2013-01-24 2021-03-29 피브로겐, 인크. 〔[1-시아노-5-(4-클로로페녹시)-4-하이드록시-아이소퀴놀린-3-카보닐]-아미노〕-아세트산의 결정 형태

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054482B1 (xx) * 1969-07-11 1973-06-08 Anvar
FR2424270A1 (fr) * 1978-04-24 1979-11-23 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0105210A2 (de) 1984-04-11
DK408083D0 (da) 1983-09-08
PH18186A (en) 1985-04-12
AU1891683A (en) 1984-03-15
NO833217L (no) 1984-03-12
IL69683A0 (en) 1983-12-30
ATE25679T1 (de) 1987-03-15
FI833200A (fi) 1984-03-10
ES525441A0 (es) 1984-05-16
HU191094B (en) 1987-01-28
NZ205513A (en) 1986-05-09
US4673682A (en) 1987-06-16
EP0105210B1 (de) 1987-03-04
GR79382B (xx) 1984-10-22
ES8404852A1 (es) 1984-05-16
KR840006206A (ko) 1984-11-22
PT77309A (de) 1983-10-01
FI833200A0 (fi) 1983-09-07
PT77309B (de) 1986-04-18
DK408083A (da) 1984-03-10
CA1211445A (en) 1986-09-16
EP0105210A3 (en) 1984-10-10
JPS5967270A (ja) 1984-04-16
DE3233424A1 (de) 1984-03-15
DE3369983D1 (en) 1987-04-09

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