DE3168433D1 - 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives - Google Patents

3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives

Info

Publication number
DE3168433D1
DE3168433D1 DE8181301335T DE3168433T DE3168433D1 DE 3168433 D1 DE3168433 D1 DE 3168433D1 DE 8181301335 T DE8181301335 T DE 8181301335T DE 3168433 T DE3168433 T DE 3168433T DE 3168433 D1 DE3168433 D1 DE 3168433D1
Authority
DE
Germany
Prior art keywords
piperidinylalkyl
pyrido
pyrimidin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181301335T
Other languages
German (de)
English (en)
Inventor
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE3168433D1 publication Critical patent/DE3168433D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8181301335T 1980-03-28 1981-03-27 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives Expired DE3168433D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (1)

Publication Number Publication Date
DE3168433D1 true DE3168433D1 (de) 1985-03-07

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181301335T Expired DE3168433D1 (de) 1980-03-28 1981-03-27 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives

Country Status (22)

Country Link
US (1) US4342870A (cg-RX-API-DMAC7.html)
EP (1) EP0037265B1 (cg-RX-API-DMAC7.html)
AU (1) AU537700B2 (cg-RX-API-DMAC7.html)
BG (1) BG36199A3 (cg-RX-API-DMAC7.html)
CA (1) CA1163994A (cg-RX-API-DMAC7.html)
CS (1) CS256366B2 (cg-RX-API-DMAC7.html)
DE (1) DE3168433D1 (cg-RX-API-DMAC7.html)
DK (1) DK159390C (cg-RX-API-DMAC7.html)
ES (1) ES500814A0 (cg-RX-API-DMAC7.html)
FI (1) FI71737C (cg-RX-API-DMAC7.html)
GR (1) GR72488B (cg-RX-API-DMAC7.html)
HU (1) HU187329B (cg-RX-API-DMAC7.html)
IE (1) IE51319B1 (cg-RX-API-DMAC7.html)
IL (1) IL62494A (cg-RX-API-DMAC7.html)
MA (1) MA19107A1 (cg-RX-API-DMAC7.html)
NO (1) NO156752C (cg-RX-API-DMAC7.html)
NZ (1) NZ196522A (cg-RX-API-DMAC7.html)
PH (1) PH16530A (cg-RX-API-DMAC7.html)
PT (1) PT72740B (cg-RX-API-DMAC7.html)
RO (1) RO82508A (cg-RX-API-DMAC7.html)
SU (1) SU1068037A3 (cg-RX-API-DMAC7.html)
YU (1) YU43010B (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0268309B1 (en) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Serotonin antagonists for treating wounds
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5153206A (en) * 1988-12-02 1992-10-06 Pfizer Inc. Arylpiperidine derivatives
WO1990011093A1 (en) * 1989-03-23 1990-10-04 Mallinckrodt, Inc. Radioactive iodine- or bromine labelled piperidine compound as well as method of preparing same and composition comprising said compound
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
KR100269756B1 (ko) * 1992-02-13 2000-10-16 슈테펜엘.네스비트 피페리디닐티아시클릭유도체(Piperidinyl Thiacyclic Derivatives)
KR100251892B1 (ko) 1992-07-13 2000-09-01 디르크 반테 신규한 4-(3-벤조푸라닐)피페리디닐 및 4-(3-벤조티에닐)피페리디닐 유도체 및 이들을 함유하는 약제학적 조성물
KR100354270B1 (ko) * 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
AU2003288017A1 (en) * 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
WO2004094415A1 (en) * 2003-04-22 2004-11-04 Synthon B.V. Risperidone monohydrochloride
WO2009108798A1 (en) 2008-02-29 2009-09-03 Vm Discovery Inc. Method for treating pain syndrome and other disorders
ES2697174T3 (es) * 2012-02-10 2019-01-22 Ptc Therapeutics Inc Compuestos para tratar atrofia muscular espinal
US9371336B2 (en) 2012-03-01 2016-06-21 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
MX358514B (es) 2012-03-23 2018-08-24 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
WO2014143915A1 (en) 2013-03-15 2014-09-18 Vm Therapeutics Llc Novel crystalline forms
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
CN108697709A (zh) 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
CN110352007A (zh) 2016-11-28 2019-10-18 Ptc医疗公司 用于调节rna剪接的方法
WO2018226622A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
EP3645121B8 (en) 2017-06-28 2025-06-18 PTC Therapeutics, Inc. Methods for treating huntington's disease
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
CA3094703A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN112805280B (zh) 2018-06-27 2024-12-06 Ptc医疗公司 用于治疗亨廷顿氏病的杂芳基化合物
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
JP7421507B2 (ja) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物

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US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
CA1163994A (en) 1984-03-20
IE810706L (en) 1981-09-28
NO156752B (no) 1987-08-10
AU6842981A (en) 1981-10-01
RO82508B (ro) 1983-08-30
AU537700B2 (en) 1984-07-05
FI71737C (fi) 1987-02-09
DK159390B (da) 1990-10-08
EP0037265A1 (en) 1981-10-07
PH16530A (en) 1983-11-10
PT72740A (en) 1981-04-01
IL62494A (en) 1984-08-31
SU1068037A3 (ru) 1984-01-15
BG36199A3 (en) 1984-09-14
FI810956L (fi) 1981-09-29
MA19107A1 (fr) 1981-10-01
CS256366B2 (en) 1988-04-15
YU81081A (en) 1983-12-31
FI71737B (fi) 1986-10-31
ES8300763A1 (es) 1982-11-01
GR72488B (cg-RX-API-DMAC7.html) 1983-11-14
IE51319B1 (en) 1986-12-10
NZ196522A (en) 1985-10-11
HU187329B (en) 1985-12-28
US4342870A (en) 1982-08-03
IL62494A0 (en) 1981-05-20
DK138281A (da) 1981-09-29
DK159390C (da) 1991-03-04
EP0037265B1 (en) 1985-01-23
PT72740B (en) 1982-11-16
NO156752C (no) 1987-11-18
NO811058L (no) 1981-09-29
RO82508A (ro) 1983-09-26
ES500814A0 (es) 1982-11-01
YU43010B (en) 1989-02-28

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8339 Ceased/non-payment of the annual fee