DE3167698D1 - Method for the determination of antigens with the aid of two or more monoclonal antibodies - Google Patents

Method for the determination of antigens with the aid of two or more monoclonal antibodies

Info

Publication number
DE3167698D1
DE3167698D1 DE8181200768T DE3167698T DE3167698D1 DE 3167698 D1 DE3167698 D1 DE 3167698D1 DE 8181200768 T DE8181200768 T DE 8181200768T DE 3167698 T DE3167698 T DE 3167698T DE 3167698 D1 DE3167698 D1 DE 3167698D1
Authority
DE
Germany
Prior art keywords
antigens
aid
determination
monoclonal antibodies
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181200768T
Other languages
English (en)
Inventor
Anna Maria Gezina Bosch
Antonius Hermanus W M Schuurs
Wilhelmus Johannes H M Stevens
Weemen Bauke Klaas Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19835673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3167698(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of DE3167698D1 publication Critical patent/DE3167698D1/de
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE8181200768T 1980-07-28 1981-07-06 Method for the determination of antigens with the aid of two or more monoclonal antibodies Expired DE3167698D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE8004308,A NL185309C (nl) 1980-07-28 1980-07-28 Methode voor het bepalen van antigenen met behulp van twee of meer monoklonale antilichamen alsmede immuunreagens.

Publications (1)

Publication Number Publication Date
DE3167698D1 true DE3167698D1 (en) 1985-01-24

Family

ID=19835673

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181200768T Expired DE3167698D1 (en) 1980-07-28 1981-07-06 Method for the determination of antigens with the aid of two or more monoclonal antibodies

Country Status (8)

Country Link
US (1) US6391563B1 (de)
EP (1) EP0045103B1 (de)
JP (2) JPS5786051A (de)
AU (1) AU549077B2 (de)
DE (1) DE3167698D1 (de)
DK (3) DK163838B (de)
ES (1) ES504285A0 (de)
NL (3) NL185309C (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2952816A (en) * 1955-10-21 1960-09-13 Gen Electric Limiting amplifier
WO1982000058A1 (en) * 1980-06-20 1982-01-07 Porter P Processes and apparatus for carrying out specific binding assays
US6406920B1 (en) 1980-06-20 2002-06-18 Inverness Medical Switzerland Gmbh Processes and apparatus for carrying out specific binding assays
EP0111762B1 (de) * 1980-06-20 1987-11-19 Unilever Plc Verfahren und Gerät zur Durchführung spezifischer Bindungsbestimmungen
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4879219A (en) * 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US4837167A (en) * 1981-01-30 1989-06-06 Centocor, Inc. Immunoassay for multi-determinant antigens using high-affinity
JPS585659A (ja) * 1981-06-24 1983-01-13 ハイブリテツク　インコ−ポレ−テツド 単クロ−ン性抗体を使用する免疫学的、抑制試験
JPS58127167A (ja) * 1982-01-26 1983-07-28 Green Cross Corp:The 逆受身モノクロ−ナル抗体赤血球凝集反応用抗原検出試薬
GB2118300B (en) * 1982-02-12 1985-06-19 Corning Glass Works Method of immunoassay
US4511662A (en) * 1982-06-18 1985-04-16 Bio-Rad Laboratories, Inc. Simultaneous assay for T and B lymphocyte populations and subpopulations
JPS5954966A (ja) * 1982-09-22 1984-03-29 Mochida Pharmaceut Co Ltd 免疫学的測定試薬
JPS6080768A (ja) * 1983-10-12 1985-05-08 Eisai Co Ltd 塩基性胎児蛋白の測定方法および試薬
US4595661A (en) * 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
US4690890A (en) * 1984-04-04 1987-09-01 Cetus Corporation Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
JPH0736016B2 (ja) * 1984-05-11 1995-04-19 和光純薬工業株式会社 免疫グロブリンの定量方法
US4707438A (en) * 1984-08-22 1987-11-17 Tel Aviv University Immunoassay for breast cancer employing monoclonal antibodies
US4654298A (en) * 1984-10-05 1987-03-31 Abbott Laboratories Method for detection of peritoneal inflammation or infection
US4845197A (en) * 1985-09-09 1989-07-04 Agri-Diagnostics Associates Monoclonal antibodies and methods for fungal pathogen detection
JPH07119762B2 (ja) * 1986-04-09 1995-12-20 和光純薬工業株式会社 補体の定量方法
JP2591750B2 (ja) * 1986-06-26 1997-03-19 オ−ソ・ダイアグノステイツク・システムズ・インコ−ポレ−テツド 免疫分析システム
US5187067A (en) * 1986-12-15 1993-02-16 Teijin Limited Immunological determination of free human protein S and C4bp-protein S complex
EP0271810B1 (de) * 1986-12-15 1994-03-09 Teijin Limited Immunologische Bestimmung von freiem menschlichem Protein-S und c4bp-Protein-S-Komplex
US5179000A (en) * 1987-07-24 1993-01-12 Nippon Kayaku Kabushiki Kaisha Method for assaying basic fetoprotein in urine and assay kit therefor
JPH01163661A (ja) * 1987-10-02 1989-06-27 E I Du Pont De Nemours & Co ＩｇＧ捕捉抗体および多重単クローン性抗体検出系を用いたイムノアツセイ
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
JPH01301165A (ja) * 1988-05-30 1989-12-05 Sekisui Chem Co Ltd 免疫測定法
DE3929119A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zum nachweis von analyten
JPH03118472A (ja) * 1989-09-29 1991-05-21 Sekisui Chem Co Ltd インスリン定量方法及び定量試薬
US5447846A (en) * 1992-07-17 1995-09-05 Fuji Photo Film C., Ltd. Homogeneous Immunoassay process using covalent conjugate of enzyme and plural monoclonal antibodies for different epitopes on analyte
JP2709296B2 (ja) * 1996-05-27 1998-02-04 オリンパス光学工業株式会社 免疫学的分析方法
JP3652029B2 (ja) * 1996-10-16 2005-05-25 積水化学工業株式会社 高感度免疫測定法
EP2042870A1 (de) * 2007-09-28 2009-04-01 Fujifilm Corporation Verfahren für einen hochempfindlichen Immunassay
GB0820999D0 (en) * 2008-11-17 2008-12-24 Menon Johansson Anatole S Pregnancy testing
JP7313659B2 (ja) * 2019-03-12 2023-07-25 株式会社シノテスト 試料中のｈｍｇｂ１の測定方法及び測定試薬

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3654090A (en) 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
ZA783261B (en) * 1977-06-15 1979-06-27 Wistar Inst Method of producing antibodies
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4115535A (en) * 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4191739A (en) * 1977-10-17 1980-03-04 General Electric Company Antigen-antibody reaction assay employing particle aggregation and resistive pulse analysis
US4244940A (en) * 1978-09-05 1981-01-13 Bio-Rad Laboratories, Inc. Single-incubation two-site immunoassay
EP0038642B1 (de) * 1980-04-09 1989-02-08 National Research Development Corporation Monoklonaler Antikörper gegen Hepatitis B und seine Herstellung, ein den monoklonalen Antikörper produzierendes Hybridom und diesen enthaltende Zusammensetzung, die Vermehrung des Hybridoms und der monoklonale Antikörper für den Gebrauch als antivirales Agenz gegen Hepatitus B und für die Isolierung von Hepatitus B Oberflächenantigen aus einer Probe
CH642458A5 (en) * 1980-04-25 1984-04-13 Hoffmann La Roche Immunological method
US4361647A (en) * 1980-05-22 1982-11-30 Palo Alto Medical Research Foundation Sandwich immunoassay and compositions for use therein
WO1982000058A1 (en) * 1980-06-20 1982-01-07 Porter P Processes and apparatus for carrying out specific binding assays
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies

Also Published As

Publication number Publication date
AU549077B2 (en) 1986-01-16
EP0045103A3 (en) 1982-02-10
NL8702777A (nl) 1988-03-01
AU7307881A (en) 1982-02-04
EP0045103A2 (de) 1982-02-03
NL8702776A (nl) 1988-03-01
DK61990A (da) 1990-03-08
NL188869B (nl) 1992-05-18
DK163839C (da) 1992-08-24
DK163840C (da) 1992-08-24
JPH0340341B2 (de) 1991-06-18
NL185309B (nl) 1989-10-02
NL186407C (nl) 1990-11-16
NL185309C (nl) 1990-03-01
JPH06258325A (ja) 1994-09-16
NL186407B (nl) 1990-06-18
DK61890D0 (da) 1990-03-08
DK163838B (da) 1992-04-06
DK315081A (da) 1982-01-29
EP0045103B1 (de) 1984-12-12
DK61890A (da) 1990-03-08
NL8004308A (nl) 1982-03-01
ES8206856A1 (es) 1982-08-16
JPS5786051A (en) 1982-05-28
ES504285A0 (es) 1982-08-16
US6391563B1 (en) 2002-05-21
DK61990D0 (da) 1990-03-08
DK163840B (da) 1992-04-06
DK163839B (da) 1992-04-06

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: AKZO NOBEL N.V., ARNHEIM/ARNHEM, NL

8331 Complete revocation