DE3005580C2 - - Google Patents

Info

Publication number
DE3005580C2
DE3005580C2 DE3005580A DE3005580A DE3005580C2 DE 3005580 C2 DE3005580 C2 DE 3005580C2 DE 3005580 A DE3005580 A DE 3005580A DE 3005580 A DE3005580 A DE 3005580A DE 3005580 C2 DE3005580 C2 DE 3005580C2
Authority
DE
Germany
Prior art keywords
compounds
acid
group
acid addition
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3005580A
Other languages
German (de)
English (en)
Other versions
DE3005580A1 (de
Inventor
Setsuro Toyonaka Osaka Jp Fuji
Tsuyoshi Kadoma Osaka Jp Watanabe
Itsuo Ashiya Hyogo Jp Okumoto
Masashi Nishinomiya Hyogo Jp Shiota
Naohiro Takatsuki Osaka Jp Kayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2257279A external-priority patent/JPS55115863A/ja
Priority claimed from JP2257179A external-priority patent/JPS55115865A/ja
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of DE3005580A1 publication Critical patent/DE3005580A1/de
Application granted granted Critical
Publication of DE3005580C2 publication Critical patent/DE3005580C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19803005580 1979-03-01 1980-02-14 Guanidinobenzoesaeurederivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel Granted DE3005580A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2257279A JPS55115863A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation
JP2257179A JPS55115865A (en) 1979-03-01 1979-03-01 Guanidinobenzoic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
DE3005580A1 DE3005580A1 (de) 1980-09-11
DE3005580C2 true DE3005580C2 (it) 1988-12-22

Family

ID=26359810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803005580 Granted DE3005580A1 (de) 1979-03-01 1980-02-14 Guanidinobenzoesaeurederivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel

Country Status (4)

Country Link
US (1) US4283418A (it)
DE (1) DE3005580A1 (it)
FR (1) FR2450251A1 (it)
GB (1) GB2044760B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423069A (en) * 1982-01-20 1983-12-27 University Of Illinois Foundation Contraceptive method
DE3429114A1 (de) * 1984-08-03 1986-02-13 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte guanidinobenzoesaeurephenylester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4746737A (en) * 1985-07-26 1988-05-24 Kowa Co., Ltd. Phenyl guanidinobenzoate derivatives which have protease inhibitory activity
US4843094A (en) * 1985-11-12 1989-06-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient
ES2039356T3 (es) * 1985-11-12 1993-10-01 Ono Pharmaceutical Co., Ltd. Un procedimiento para la preparacion de derivados del acido p-guanidinobenzoico.
US5247084A (en) * 1985-11-12 1993-09-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid
JPH0676373B2 (ja) * 1985-12-27 1994-09-28 エーザイ株式会社 グアニジノ安息香酸エステル誘導体
US6388122B1 (en) 1996-04-10 2002-05-14 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3864000A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
EP1934167A2 (en) * 2006-07-26 2008-06-25 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
CA2795023A1 (en) * 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
WO2012178102A2 (en) 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
BR112014006125B1 (pt) * 2011-09-15 2022-05-10 Astellas Pharma Inc Composto de ácido guanidinobenzóico, composição farmacêutica e uso de tal composto
EP2802653A4 (en) 2012-01-10 2015-09-02 Univ Colorado Regents ALPHA-1 ANTITRYPSIN FUSION MOLECULE COMPOSITIONS, METHODS AND USES THEREOF
CN114805141A (zh) * 2021-01-27 2022-07-29 中国科学院上海药物研究所 4-胍基苯甲酸芳基酯类化合物及其在抗SARS-CoV-2病毒中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
GB1472700A (en) * 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
JPS5470241A (en) 1977-11-09 1979-06-05 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivative and its preparation

Also Published As

Publication number Publication date
FR2450251B1 (it) 1983-02-18
DE3005580A1 (de) 1980-09-11
GB2044760B (en) 1983-03-23
FR2450251A1 (fr) 1980-09-26
GB2044760A (en) 1980-10-22
US4283418A (en) 1981-08-11

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee