DE2927294A1 - Neue 4-phenyl-4,5,6,7-tetrahydropyrrolo eckige klammer auf 2,3-c eckige klammer zu pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen - Google Patents
Neue 4-phenyl-4,5,6,7-tetrahydropyrrolo eckige klammer auf 2,3-c eckige klammer zu pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungenInfo
- Publication number
- DE2927294A1 DE2927294A1 DE19792927294 DE2927294A DE2927294A1 DE 2927294 A1 DE2927294 A1 DE 2927294A1 DE 19792927294 DE19792927294 DE 19792927294 DE 2927294 A DE2927294 A DE 2927294A DE 2927294 A1 DE2927294 A1 DE 2927294A1
- Authority
- DE
- Germany
- Prior art keywords
- pyridine
- hydrogen
- general formula
- acid addition
- tetrahydropyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000000034 method Methods 0.000 title claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title description 8
- 238000004519 manufacturing process Methods 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
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- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000000460 chlorine Substances 0.000 claims description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
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- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001519 thymoleptic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792927294 DE2927294A1 (de) | 1979-07-06 | 1979-07-06 | Neue 4-phenyl-4,5,6,7-tetrahydropyrrolo eckige klammer auf 2,3-c eckige klammer zu pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| IT23120/80A IT1150024B (it) | 1979-07-06 | 1980-06-30 | 4-fenil-4,5,6,7-tetraidropirrolo(2,3-c) piridine,procedimento per la loro fabbricazione,nonche'composizioni farmaceutiche relative |
| US06/163,969 US4315938A (en) | 1979-07-06 | 1980-06-30 | 4-Phenyl-4,5,6,7-tetrahydro-pyrrolo [2,3-c] pyridines and salts thereof |
| AT0344680A AT375077B (de) | 1979-07-06 | 1980-07-02 | Verfahren zur herstellung neuer 4-phenyl-4,5,6,7tetrahydropyrrolo(2,3-c)pyridine |
| YU01747/80A YU174780A (en) | 1979-07-06 | 1980-07-03 | Process for preparing new imidazo-isoquinoline diones |
| GR62353A GR69327B (enExample) | 1979-07-06 | 1980-07-03 | |
| CH5125/80A CH649548A5 (de) | 1979-07-06 | 1980-07-03 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo(2,3-c)pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten. |
| NZ194245A NZ194245A (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydropyrrolo(2,3-c)pyridines |
| BE0/201313A BE884193A (fr) | 1979-07-06 | 1980-07-04 | NOUVELLES 4-PHENYL-4,5,6,7-TETRAHYDROPYRROLO(2,3-c)PYRIDINES PROCEDE POUR LEUR PREPARATION ET MEDICAMENTS LES RENFERMANT |
| IL60499A IL60499A (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo(2,3-c)-pyridines,their production and pharmaceutical compositions containing them |
| ES493104A ES493104A0 (es) | 1979-07-06 | 1980-07-04 | Procedimiento para la preparacion de nuevas 4-fenil-4,5,6, 7-tetrahidro-pirrolo(2,3-c)piridinas |
| NO802014A NO802014L (no) | 1979-07-06 | 1980-07-04 | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolo-pyridinderivater |
| CA000355540A CA1138864A (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo[2,3-c] pyridines, process for the production thereof and pharmaceutical compositions |
| DK290380A DK290380A (da) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo (2,3-c) pyridiner fremgangsmaade til deres fremstilling samt deres anvendlse |
| FR8015010A FR2460950A1 (fr) | 1979-07-06 | 1980-07-04 | Nouvelles 4-phenyl-4,5,6,7-tetrahydropyrrolo(2,3-c)pyridines, procede pour leur preparation et medicaments les renfermant |
| SE8004976A SE436747B (sv) | 1979-07-06 | 1980-07-04 | 4-fenyl-4,5,6,7-tetrahydro-pyrrolo/2,3-c/pyridiner, forfarande for deras framstellning och farmaceutiska kompositioner |
| LU82582A LU82582A1 (de) | 1979-07-06 | 1980-07-04 | Neue 4-phenyl-4,5,6,7-tetrahydro-pyrrolo(2,3-c)pyridine,verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| ZA00804031A ZA804031B (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo (2,3-c) pyridines process for their preparation and pharmaceutical compositions thereof |
| FI802148A FI802148A7 (fi) | 1979-07-06 | 1980-07-04 | Uudet 4- fenyyli-4,5,6,7-tetrahydro- pyrrolo/2,3-c/-pyridiinit, niiden valmistusmenetelmä ja farmaseuttisetseokset. |
| HU801678A HU182152B (en) | 1979-07-06 | 1980-07-04 | Process for preparing new phenyl-4,5,6,7-tetrahydro-pyrrolo/2,3-c/pyridines |
| PT71500A PT71500B (de) | 1979-07-06 | 1980-07-04 | Neue 4-phenyl-4,5,6,7-tetrahydro-pyrrolo<2,3-c>pyririne verfah-ren zu ihrer herstellung und pharmazeutische zusammenstzungen |
| NL8003879A NL8003879A (nl) | 1979-07-06 | 1980-07-04 | Nieuwe 4-fenyl-4.5.6.7-tetrahydro-pyrrolo/2,3-c/pyri- dinen, werkwijze ter bereiding daarvan, en farmaceutische preparatn, die deze verbindingen bevatten. |
| GB8022046A GB2054580B (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrolo(2,3-c)-pyridines process for the preparation and pharmaceutical compositions thereof |
| JP9161580A JPS5610184A (en) | 1979-07-06 | 1980-07-04 | Pyridine derivatives and medicinal composition containing them |
| AU60138/80A AU536336B2 (en) | 1979-07-06 | 1980-07-04 | 4-phenyl-4,5,6,7-tetrahydro-pyrrrolo(2,3-c)-pyridines |
| PH24246A PH15756A (en) | 1979-07-06 | 1980-07-07 | Novel 4-phenyl-4,5,6,7-tetrahydro-pyrrolo(2,3-c)pyridines and salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792927294 DE2927294A1 (de) | 1979-07-06 | 1979-07-06 | Neue 4-phenyl-4,5,6,7-tetrahydropyrrolo eckige klammer auf 2,3-c eckige klammer zu pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2927294A1 true DE2927294A1 (de) | 1981-01-08 |
Family
ID=6075042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792927294 Withdrawn DE2927294A1 (de) | 1979-07-06 | 1979-07-06 | Neue 4-phenyl-4,5,6,7-tetrahydropyrrolo eckige klammer auf 2,3-c eckige klammer zu pyridine, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4315938A (enExample) |
| JP (1) | JPS5610184A (enExample) |
| AT (1) | AT375077B (enExample) |
| AU (1) | AU536336B2 (enExample) |
| BE (1) | BE884193A (enExample) |
| CA (1) | CA1138864A (enExample) |
| CH (1) | CH649548A5 (enExample) |
| DE (1) | DE2927294A1 (enExample) |
| DK (1) | DK290380A (enExample) |
| ES (1) | ES493104A0 (enExample) |
| FI (1) | FI802148A7 (enExample) |
| FR (1) | FR2460950A1 (enExample) |
| GB (1) | GB2054580B (enExample) |
| GR (1) | GR69327B (enExample) |
| HU (1) | HU182152B (enExample) |
| IL (1) | IL60499A (enExample) |
| IT (1) | IT1150024B (enExample) |
| LU (1) | LU82582A1 (enExample) |
| NL (1) | NL8003879A (enExample) |
| NO (1) | NO802014L (enExample) |
| NZ (1) | NZ194245A (enExample) |
| PH (1) | PH15756A (enExample) |
| PT (1) | PT71500B (enExample) |
| SE (1) | SE436747B (enExample) |
| YU (1) | YU174780A (enExample) |
| ZA (1) | ZA804031B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5890951A (ja) * | 1981-11-26 | 1983-05-30 | 住友金属工業株式会社 | 耐食性にすぐれた積層板 |
| JPS59193175A (ja) * | 1983-04-19 | 1984-11-01 | Toa Nenryo Kogyo Kk | 積層物 |
| US4572911A (en) * | 1984-08-02 | 1986-02-25 | Mcneilab, Inc. | Hexahydroindolinzine compounds, pharmaceutical compositions and methods and intermediates |
| EP4003339A4 (en) * | 2019-07-30 | 2023-02-22 | Sanford Burnham Prebys Medical Discovery Institute | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1484140A (en) * | 1974-04-24 | 1977-08-24 | Wyeth John & Brother Ltd | Pyrrolopyridine derivatives |
| AT368504B (de) * | 1977-10-15 | 1982-10-25 | Boehringer Sohn Ingelheim | Verfahren zur herstellung neuer 4-phenyl-thieno- (2,3-c)-piperidine |
-
1979
- 1979-07-06 DE DE19792927294 patent/DE2927294A1/de not_active Withdrawn
-
1980
- 1980-06-30 IT IT23120/80A patent/IT1150024B/it active
- 1980-06-30 US US06/163,969 patent/US4315938A/en not_active Expired - Lifetime
- 1980-07-02 AT AT0344680A patent/AT375077B/de not_active IP Right Cessation
- 1980-07-03 CH CH5125/80A patent/CH649548A5/de not_active IP Right Cessation
- 1980-07-03 YU YU01747/80A patent/YU174780A/xx unknown
- 1980-07-03 GR GR62353A patent/GR69327B/el unknown
- 1980-07-04 ZA ZA00804031A patent/ZA804031B/xx unknown
- 1980-07-04 SE SE8004976A patent/SE436747B/sv unknown
- 1980-07-04 HU HU801678A patent/HU182152B/hu unknown
- 1980-07-04 NO NO802014A patent/NO802014L/no unknown
- 1980-07-04 ES ES493104A patent/ES493104A0/es active Granted
- 1980-07-04 FR FR8015010A patent/FR2460950A1/fr active Granted
- 1980-07-04 NL NL8003879A patent/NL8003879A/nl not_active Application Discontinuation
- 1980-07-04 LU LU82582A patent/LU82582A1/de unknown
- 1980-07-04 BE BE0/201313A patent/BE884193A/fr not_active IP Right Cessation
- 1980-07-04 IL IL60499A patent/IL60499A/xx unknown
- 1980-07-04 CA CA000355540A patent/CA1138864A/en not_active Expired
- 1980-07-04 AU AU60138/80A patent/AU536336B2/en not_active Ceased
- 1980-07-04 PT PT71500A patent/PT71500B/pt unknown
- 1980-07-04 DK DK290380A patent/DK290380A/da not_active Application Discontinuation
- 1980-07-04 GB GB8022046A patent/GB2054580B/en not_active Expired
- 1980-07-04 NZ NZ194245A patent/NZ194245A/en unknown
- 1980-07-04 JP JP9161580A patent/JPS5610184A/ja active Pending
- 1980-07-04 FI FI802148A patent/FI802148A7/fi not_active Application Discontinuation
- 1980-07-07 PH PH24246A patent/PH15756A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT375077B (de) | 1984-06-25 |
| AU536336B2 (en) | 1984-05-03 |
| CH649548A5 (de) | 1985-05-31 |
| JPS5610184A (en) | 1981-02-02 |
| SE8004976L (sv) | 1981-01-07 |
| IT8023120A0 (it) | 1980-06-30 |
| IL60499A (en) | 1984-02-29 |
| LU82582A1 (de) | 1981-09-10 |
| HU182152B (en) | 1983-12-28 |
| CA1138864A (en) | 1983-01-04 |
| IL60499A0 (en) | 1980-09-16 |
| NL8003879A (nl) | 1981-01-08 |
| NZ194245A (en) | 1984-07-06 |
| PT71500B (de) | 1981-12-11 |
| FR2460950A1 (fr) | 1981-01-30 |
| FI802148A7 (fi) | 1981-01-01 |
| NO802014L (no) | 1981-01-07 |
| FR2460950B1 (enExample) | 1983-06-24 |
| GB2054580A (en) | 1981-02-18 |
| BE884193A (fr) | 1981-01-05 |
| DK290380A (da) | 1981-01-07 |
| ATA344680A (de) | 1983-11-15 |
| GB2054580B (en) | 1983-04-07 |
| GR69327B (enExample) | 1982-05-17 |
| US4315938A (en) | 1982-02-16 |
| ES8201019A1 (es) | 1981-11-01 |
| AU6013880A (en) | 1981-01-15 |
| IT1150024B (it) | 1986-12-10 |
| ZA804031B (en) | 1982-03-31 |
| SE436747B (sv) | 1985-01-21 |
| YU174780A (en) | 1983-02-28 |
| PT71500A (de) | 1980-08-01 |
| PH15756A (en) | 1983-03-18 |
| ES493104A0 (es) | 1981-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |