DE2835695A1 - Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten - Google Patents

Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten

Info

Publication number
DE2835695A1
DE2835695A1 DE19782835695 DE2835695A DE2835695A1 DE 2835695 A1 DE2835695 A1 DE 2835695A1 DE 19782835695 DE19782835695 DE 19782835695 DE 2835695 A DE2835695 A DE 2835695A DE 2835695 A1 DE2835695 A1 DE 2835695A1
Authority
DE
Germany
Prior art keywords
group
solution
mixture
ethanol
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782835695
Other languages
German (de)
English (en)
Inventor
Yasufumi Hirata
Masaaki Takeda
Toshinari Tamura
Isao Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10407977A external-priority patent/JPS5444660A/ja
Priority claimed from JP8694478A external-priority patent/JPS5515415A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of DE2835695A1 publication Critical patent/DE2835695A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19782835695 1977-08-29 1978-08-16 Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten Withdrawn DE2835695A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10407977A JPS5444660A (en) 1977-08-29 1977-08-29 Heterocyclic compound and its preparation
JP8694478A JPS5515415A (en) 1978-07-17 1978-07-17 Heterocyclic compound and its preparation

Publications (1)

Publication Number Publication Date
DE2835695A1 true DE2835695A1 (de) 1979-03-15

Family

ID=26428021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782835695 Withdrawn DE2835695A1 (de) 1977-08-29 1978-08-16 Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten

Country Status (7)

Country Link
US (1) US4379158A (enExample)
CA (1) CA1125298A (enExample)
DE (1) DE2835695A1 (enExample)
FR (1) FR2401914A1 (enExample)
GB (1) GB2003471B (enExample)
IT (1) IT1113092B (enExample)
SE (1) SE7809035L (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023578A1 (en) * 1979-07-03 1981-02-11 Shionogi & Co., Ltd. Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
EP0100425A1 (de) * 1982-07-03 1984-02-15 Bayer Ag Substituierte Diphenylether, Verfahren zu ihren Herstellung und ihre Verwendung als Herbizide
EP0089153A3 (en) * 1982-03-17 1984-07-11 Smith Kline & French Laboratories Limited Pyridine derivatives
EP0214823A3 (en) * 1985-08-29 1990-05-02 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Alkylamide derivatives with h2-receptor antagonistic and cytoprotective action
US5660361A (en) * 1994-02-16 1997-08-26 Anton Steinecker Entwicklungs Gmbh & Co. Rotary device for supporting receptacles

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228941A1 (es) 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
JPS55120571A (en) * 1979-03-02 1980-09-17 Glaxo Group Ltd Heterocyclic derivative
ZA801151B (en) * 1979-03-02 1981-02-25 Glaxo Group Ltd Heterocyclic derivatives
EP0028483B1 (en) * 1979-10-22 1984-04-18 Glaxo Group Limited 1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US4238487A (en) 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
CH655104A5 (fr) * 1980-02-28 1986-03-27 Glaxo Group Ltd Derives heterocycliques triazoliques, procedes pour leur preparation et compositions pharmaceutiques les comportant.
EP0048555B1 (en) * 1980-08-27 1985-12-04 Glaxo Group Limited Amino-1,2,4-triazole derivatives, processes for their preparation and pharmaceutical compositions containing them
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
CA1209998A (en) * 1981-03-09 1986-08-19 David J. Gilman Amide derivatives as histamine h-2 receptor antagonists
IN158869B (enExample) * 1981-03-18 1987-02-07 Ici Plc
EP0067508B1 (en) * 1981-05-18 1985-10-30 Imperial Chemical Industries Plc Amidine derivatives
AU547405B2 (en) * 1981-07-08 1985-10-17 Sanofi Amidobenzamides
FR2509305B1 (fr) * 1981-07-08 1986-04-18 Sanofi Sa Benzamides, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
US4496737A (en) * 1982-09-27 1985-01-29 Merck & Co., Inc. Process for preparing sulfamylamidine antisecretory agents
US4927851A (en) * 1986-01-07 1990-05-22 Sandoz Pharm. Corp. Analogs of mevalonolactone and derivatives thereof
US4829081A (en) * 1986-01-07 1989-05-09 Sandoz Pharm. Corp. Analogs of mevalonolactone and derivatives thereof
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP2608439B2 (ja) * 1988-01-25 1997-05-07 三菱レイヨン株式会社 耐衝撃性樹脂組成物
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558640A (en) * 1967-12-20 1971-01-26 Merck & Co Inc Certain pyridyl and thiazolyl methylthiopropionic acids and derivatives
US4104382A (en) * 1972-04-20 1978-08-01 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors
GB1398426A (en) 1972-09-05 1975-06-18 Smith Kline French Lab Heterocyclic substituted guanidines

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023578A1 (en) * 1979-07-03 1981-02-11 Shionogi & Co., Ltd. Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
EP0089153A3 (en) * 1982-03-17 1984-07-11 Smith Kline & French Laboratories Limited Pyridine derivatives
EP0100425A1 (de) * 1982-07-03 1984-02-15 Bayer Ag Substituierte Diphenylether, Verfahren zu ihren Herstellung und ihre Verwendung als Herbizide
EP0214823A3 (en) * 1985-08-29 1990-05-02 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Alkylamide derivatives with h2-receptor antagonistic and cytoprotective action
US5660361A (en) * 1994-02-16 1997-08-26 Anton Steinecker Entwicklungs Gmbh & Co. Rotary device for supporting receptacles

Also Published As

Publication number Publication date
GB2003471A (en) 1979-03-14
CA1125298A (en) 1982-06-08
FR2401914A1 (fr) 1979-03-30
GB2003471B (en) 1982-04-07
IT7826925A0 (it) 1978-08-22
SE7809035L (sv) 1979-03-01
US4379158A (en) 1983-04-05
IT1113092B (it) 1986-01-20
FR2401914B1 (enExample) 1981-05-08

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee