DE2817082A1 - Verfahren zur herstellung von thymosin alpha tief 1 und einem analogen - Google Patents

Verfahren zur herstellung von thymosin alpha tief 1 und einem analogen

Info

Publication number
DE2817082A1
DE2817082A1 DE19782817082 DE2817082A DE2817082A1 DE 2817082 A1 DE2817082 A1 DE 2817082A1 DE 19782817082 DE19782817082 DE 19782817082 DE 2817082 A DE2817082 A DE 2817082A DE 2817082 A1 DE2817082 A1 DE 2817082A1
Authority
DE
Germany
Prior art keywords
obzi
bzi
lys
giu
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782817082
Other languages
German (de)
English (en)
Inventor
Su-Sun Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/871,563 external-priority patent/US4116951A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2817082A1 publication Critical patent/DE2817082A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE19782817082 1977-04-22 1978-04-19 Verfahren zur herstellung von thymosin alpha tief 1 und einem analogen Ceased DE2817082A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78989877A 1977-04-22 1977-04-22
US05/871,563 US4116951A (en) 1977-04-22 1978-01-23 [Asn2 ]-thymosin α1 and analogs thereof

Publications (1)

Publication Number Publication Date
DE2817082A1 true DE2817082A1 (de) 1978-11-02

Family

ID=27120967

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782817082 Ceased DE2817082A1 (de) 1977-04-22 1978-04-19 Verfahren zur herstellung von thymosin alpha tief 1 und einem analogen

Country Status (18)

Country Link
JP (1) JPS53137914A (enExample)
AT (1) AT364470B (enExample)
CA (1) CA1113088A (enExample)
CH (3) CH641152A5 (enExample)
DE (1) DE2817082A1 (enExample)
DK (1) DK147918C (enExample)
ES (1) ES469016A1 (enExample)
FI (1) FI781241A7 (enExample)
FR (2) FR2401134A1 (enExample)
GB (1) GB1590668A (enExample)
GR (1) GR71886B (enExample)
HU (1) HU180783B (enExample)
IT (1) IT1113134B (enExample)
LU (1) LU79488A1 (enExample)
NL (1) NL7804364A (enExample)
NO (2) NO781404L (enExample)
PT (1) PT67937B (enExample)
SE (1) SE447262B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
EP0033384A3 (en) * 1980-01-18 1981-11-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
WO1994018233A1 (en) * 1993-02-03 1994-08-18 Alpha 1 Biomedicals, Inc. Thymosin alpha-1 derivatives

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
EP0056594B1 (de) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunregulierender Wirkung und Thymosin-alpha-1-Fragmente
US6262230B1 (en) * 1994-01-28 2001-07-17 Sciclone Pharmaceuticals Inc. Analogs of thymosin α1

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
EP0033384A3 (en) * 1980-01-18 1981-11-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments
WO1994018233A1 (en) * 1993-02-03 1994-08-18 Alpha 1 Biomedicals, Inc. Thymosin alpha-1 derivatives
US5512656A (en) * 1993-02-03 1996-04-30 Alpha 1 Biomedicals, Inc. Thymosin alpha-1 derivatives

Also Published As

Publication number Publication date
SE7804612L (sv) 1978-12-20
DK147918C (da) 1985-08-19
FR2405926A1 (fr) 1979-05-11
GB1590668A (en) 1981-06-03
GR71886B (enExample) 1983-08-04
NO148924C (no) 1984-01-11
CA1113088A (en) 1981-11-24
IT1113134B (it) 1986-01-20
AT364470B (de) 1981-10-27
CH641153A5 (en) 1984-02-15
CH640218A5 (en) 1983-12-30
NO148924B (no) 1983-10-03
NL7804364A (nl) 1978-10-24
SE447262B (sv) 1986-11-03
FR2405926B1 (enExample) 1983-09-09
NO781404L (no) 1978-10-24
FR2401134A1 (fr) 1979-03-23
HU180783B (en) 1983-04-29
PT67937B (en) 1980-04-07
LU79488A1 (de) 1979-05-25
JPS53137914A (en) 1978-12-01
FI781241A7 (fi) 1978-10-23
ES469016A1 (es) 1980-01-01
DK169478A (da) 1978-10-23
NO821608L (no) 1978-10-24
CH641152A5 (en) 1984-02-15
PT67937A (en) 1978-05-01
DK147918B (da) 1985-01-07
IT7822629A0 (it) 1978-04-21
FR2401134B1 (enExample) 1983-09-30
ATA286178A (de) 1981-03-15

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Legal Events

Date Code Title Description
OB Request for examination as to novelty
OC Search report available
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: LEDERER, F., DIPL.-CHEM. DR., PAT.-ANW., 8000 MUEN

8131 Rejection