DE2723878A1 - Roentgenkontrastmittel auf bariumsulfatbasis und ihr herstellungsverfahren - Google Patents
Roentgenkontrastmittel auf bariumsulfatbasis und ihr herstellungsverfahrenInfo
- Publication number
- DE2723878A1 DE2723878A1 DE19772723878 DE2723878A DE2723878A1 DE 2723878 A1 DE2723878 A1 DE 2723878A1 DE 19772723878 DE19772723878 DE 19772723878 DE 2723878 A DE2723878 A DE 2723878A DE 2723878 A1 DE2723878 A1 DE 2723878A1
- Authority
- DE
- Germany
- Prior art keywords
- barium sulfate
- polyacrylamide
- ray contrast
- medium according
- contrast medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 229910052788 barium Inorganic materials 0.000 title 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 title 1
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 69
- 239000002872 contrast media Substances 0.000 claims description 46
- 229940039231 contrast media Drugs 0.000 claims description 31
- 229920002401 polyacrylamide Polymers 0.000 claims description 31
- 239000002518 antifoaming agent Substances 0.000 claims description 12
- 239000008365 aqueous carrier Substances 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 24
- 239000000725 suspension Substances 0.000 description 16
- 229920001296 polysiloxane Polymers 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 11
- 235000013355 food flavoring agent Nutrition 0.000 description 11
- 235000003599 food sweetener Nutrition 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 239000003765 sweetening agent Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 9
- 239000003651 drinking water Substances 0.000 description 9
- 235000020188 drinking water Nutrition 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 9
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 9
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 9
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 9
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 9
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 238000000265 homogenisation Methods 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- 229960000281 trometamol Drugs 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 3
- 229910052601 baryte Inorganic materials 0.000 description 3
- 239000010428 baryte Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 235000010678 Paulownia tomentosa Nutrition 0.000 description 1
- 240000002834 Paulownia tomentosa Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001621 bismuth Chemical class 0.000 description 1
- 229940036348 bismuth carbonate Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- -1 handling Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- ZCUFMDLYAMJYST-UHFFFAOYSA-N thorium dioxide Chemical compound O=[Th]=O ZCUFMDLYAMJYST-UHFFFAOYSA-N 0.000 description 1
- 229910003452 thorium oxide Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7615975A FR2352544A1 (fr) | 1976-05-26 | 1976-05-26 | Nouveau medicament pour opacification barytee et procede de preparation de ce nouveau medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2723878A1 true DE2723878A1 (de) | 1977-12-15 |
| DE2723878C2 DE2723878C2 (US20030199744A1-20031023-C00003.png) | 1987-10-22 |
Family
ID=9173679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772723878 Granted DE2723878A1 (de) | 1976-05-26 | 1977-05-26 | Roentgenkontrastmittel auf bariumsulfatbasis und ihr herstellungsverfahren |
Country Status (13)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63876A0 (en) * | 1980-10-20 | 1981-12-31 | Population Res Inc | Radiopaque cyanoacrylates |
| US4477439A (en) * | 1981-04-13 | 1984-10-16 | Walter J. Monacelli | Treatment of irritated and excoriated areas around the stoma of ostomy patients |
| GR880100428A (el) * | 1988-06-29 | 1990-05-11 | Georgios Kallimanis | Μεθοδος παρασκευης γαλακτωδους θειικου βαριου,προς ληψιν ακτινογραφιων διπλης αντιθεσεως |
| JP2722218B2 (ja) * | 1988-09-22 | 1998-03-04 | 太田製薬株式会社 | 大腸ｘ線検査用硫酸バリウム造影剤 |
| US5013560A (en) * | 1989-03-17 | 1991-05-07 | The Procter & Gamble Company | Microbially-stable bismuth-containing liquid pharmaceutical suspensions |
| US5496535A (en) * | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
| US5318768A (en) * | 1992-05-01 | 1994-06-07 | Sterling Winthrop Inc. | Polymeric x-ray contrast compositions containing an organic crystalline x-ray contrast agent |
| US5405600A (en) * | 1992-05-01 | 1995-04-11 | Sterling Winthrop Inc. | X-ray contrast compositions containing film-forming materials |
| US5443814A (en) * | 1992-05-01 | 1995-08-22 | Sterling Winthrop, Inc. | X-ray contrast compositions containing iodophenoxyalkanes and cellulose derivatives |
| US5476646A (en) * | 1992-05-01 | 1995-12-19 | Sterling Winthrop Inc. | X-ray contrast compositions containing iodophenoxyalkanes and pharmaceutically acceptable clays |
| US5352434A (en) * | 1992-05-01 | 1994-10-04 | Sterling Winthrop Inc. | X-ray contrast compositions containing a barium salt and film-forming materials |
| US5342605A (en) * | 1992-05-01 | 1994-08-30 | Sterling Winthrop Inc. | Polymeric X-ray compositions containing iodinated polymeric beads |
| US5326553A (en) * | 1993-02-02 | 1994-07-05 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract |
| US5330740A (en) * | 1993-03-01 | 1994-07-19 | Sterling Winthrop Inc. | Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract |
| US5424056A (en) * | 1993-03-01 | 1995-06-13 | Sterling Wintrhop Inc. | X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays |
| US5310538A (en) * | 1993-03-11 | 1994-05-10 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkylene ethers in film-forming materials for visualization of the gastrointestinal tract |
| US5312616A (en) * | 1993-03-11 | 1994-05-17 | Sterling Winthrop Inc. | Compositions of iodobenzoic acid derivatives in film-forming materials for visualization of the gastrointestinal tract |
| US5336484A (en) * | 1993-03-31 | 1994-08-09 | Sterling Winthrop Inc. | Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastronintestinal tract |
| US5368837A (en) * | 1994-04-14 | 1994-11-29 | Sterling Winthrop Inc. | X-ray contrast compositions containing an organic crystalline X-ray contrast agent and a cellulose derivative |
| US5543132A (en) * | 1994-04-14 | 1996-08-06 | Sterling Winthrop Inc. | X-ray contrast compositions containing a barium salt and a cellulose derivative |
| US5525327A (en) * | 1994-04-14 | 1996-06-11 | Sterling Winthrop Inc. | Polymeric x-ray contrast compositions containing iodinated polymeric beads and microcrystaline cellulose |
| US5360604A (en) * | 1994-04-14 | 1994-11-01 | Sterling Winthrop Inc. | X-ray contrast compositions containing an organic crystalline X-ray contrast agent in combination with pharmaceutically acceptable clays |
| US5593657A (en) * | 1995-02-09 | 1997-01-14 | Nanosystems L.L.C. | Barium salt formulations stabilized by non-ionic and anionic stabilizers |
| ES2112765B1 (es) * | 1995-08-02 | 1999-03-01 | Cantabria Ind Farmaceutica Sa | Procedimiento para la obtencion de formulaciones de constraste radiologico, para exploraciones gastrointestinales de uso extemporaneo y directo. |
| US7591998B2 (en) * | 2000-03-07 | 2009-09-22 | Kevin Tait | Stool marker |
| AUPQ605500A0 (en) * | 2000-03-07 | 2000-03-30 | Medefield Pty Ltd | Stool marker |
| US20060009694A1 (en) * | 2004-05-17 | 2006-01-12 | Yousefzadeh David K | Methods of attenuating internal radiation exposure |
| US20080085892A1 (en) * | 2006-08-31 | 2008-04-10 | Sangeetha Kandeepan | Liquid dosage form of acetaminophen |
| JP5742087B2 (ja) * | 2008-08-29 | 2015-07-01 | オイレス工業株式会社 | 複層摺動部材及びそれを用いた自動車のラックピニオン式舵取装置におけるラックガイド |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539682A (en) * | 1967-06-23 | 1970-11-10 | Astra Ab | X-ray contrast medium containing barium sulphate |
| DE2510221A1 (de) * | 1974-03-14 | 1975-09-18 | Pharmacia Ab | Roentgenkontrastmittelzubereitung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1128922A (en) * | 1964-10-14 | 1968-10-02 | Chugai Pharmaceutical Co Ltd | Adjuvants for gastric and intestinal x-ray photographic examination |
| FR2077687B1 (US20030199744A1-20031023-C00003.png) * | 1970-02-05 | 1973-03-16 | Roussel Uclaf |
-
1976
- 1976-05-26 FR FR7615975A patent/FR2352544A1/fr active Granted
-
1977
- 1977-05-13 IL IL52081A patent/IL52081A/xx unknown
- 1977-05-18 ZA ZA00772966A patent/ZA772966B/xx unknown
- 1977-05-18 CA CA278,687A patent/CA1091579A/fr not_active Expired
- 1977-05-23 US US05/799,163 patent/US4120946A/en not_active Expired - Lifetime
- 1977-05-25 NL NL7705738A patent/NL7705738A/xx not_active Application Discontinuation
- 1977-05-25 AU AU25488/77A patent/AU507889B2/en not_active Expired
- 1977-05-25 BE BE177900A patent/BE855032A/xx unknown
- 1977-05-26 DE DE19772723878 patent/DE2723878A1/de active Granted
- 1977-05-26 IE IE1088/77A patent/IE45288B1/en unknown
- 1977-05-26 GB GB22229/77A patent/GB1553482A/en not_active Expired
- 1977-05-26 JP JP6053477A patent/JPS52145526A/ja active Granted
- 1977-05-26 HU HU77RO00000931A patent/HU173006B/hu unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539682A (en) * | 1967-06-23 | 1970-11-10 | Astra Ab | X-ray contrast medium containing barium sulphate |
| DE2510221A1 (de) * | 1974-03-14 | 1975-09-18 | Pharmacia Ab | Roentgenkontrastmittelzubereitung |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS52145526A (en) | 1977-12-03 |
| GB1553482A (en) | 1979-09-26 |
| IE45288B1 (en) | 1982-07-28 |
| NL7705738A (nl) | 1977-11-29 |
| ZA772966B (en) | 1978-06-28 |
| CA1091579A (fr) | 1980-12-16 |
| FR2352544A1 (fr) | 1977-12-23 |
| BE855032A (fr) | 1977-11-25 |
| AU2548877A (en) | 1978-11-30 |
| US4120946A (en) | 1978-10-17 |
| HU173006B (hu) | 1979-01-28 |
| AU507889B2 (en) | 1980-02-28 |
| IE45288L (en) | 1977-11-26 |
| DE2723878C2 (US20030199744A1-20031023-C00003.png) | 1987-10-22 |
| FR2352544B1 (US20030199744A1-20031023-C00003.png) | 1978-10-20 |
| IL52081A (en) | 1980-05-30 |
| JPS618044B2 (US20030199744A1-20031023-C00003.png) | 1986-03-11 |
| IL52081A0 (en) | 1977-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |