DE266603T1 - Herstellung von kopolyanhydriden. - Google Patents
Herstellung von kopolyanhydriden.Info
- Publication number
- DE266603T1 DE266603T1 DE198787115172T DE87115172T DE266603T1 DE 266603 T1 DE266603 T1 DE 266603T1 DE 198787115172 T DE198787115172 T DE 198787115172T DE 87115172 T DE87115172 T DE 87115172T DE 266603 T1 DE266603 T1 DE 266603T1
- Authority
- DE
- Germany
- Prior art keywords
- prepolymers
- diacids
- individual
- copolymers
- anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 claims abstract 11
- 238000000034 method Methods 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 3
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 15
- 239000000178 monomer Substances 0.000 claims 3
- 238000001953 recrystallisation Methods 0.000 claims 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims 2
- WMRCTEPOPAZMMN-UHFFFAOYSA-N 2-undecylpropanedioic acid Chemical compound CCCCCCCCCCCC(C(O)=O)C(O)=O WMRCTEPOPAZMMN-UHFFFAOYSA-N 0.000 claims 1
- DFOCUWFSRVQSNI-UHFFFAOYSA-N 3-[4-(2-carboxyethyl)phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=C(CCC(O)=O)C=C1 DFOCUWFSRVQSNI-UHFFFAOYSA-N 0.000 claims 1
- LFPLRGMCQXEYDO-UHFFFAOYSA-N 4-[1-(4-carboxyphenoxy)propoxy]benzoic acid Chemical compound C=1C=C(C(O)=O)C=CC=1OC(CC)OC1=CC=C(C(O)=O)C=C1 LFPLRGMCQXEYDO-UHFFFAOYSA-N 0.000 claims 1
- FQJXYULOQZUKBZ-UHFFFAOYSA-N 4-[6-(4-carboxyphenoxy)hexoxy]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1OCCCCCCOC1=CC=C(C(O)=O)C=C1 FQJXYULOQZUKBZ-UHFFFAOYSA-N 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 229920002732 Polyanhydride Polymers 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
- C08G67/04—Polyanhydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Polyesters Or Polycarbonates (AREA)
- Polyethers (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (6)
1. Verfahren zur Herstellung von hochreinen Anhydridcopolymeren,
umfassend:
Auswahl von wenigstens zwei Disäuren, wobei diese Disäuren einzeln synthetisiert und gereinigt sind,
Umsetzen der einzelnen Disäuren und von Essigsäureanhydrid getrennt unter Bildung von Prepolymeren,
getrennte Umkristallisation der durch die Reaktion
des Essigsäureanhydrids mit diesen Disäuren gebildeten, einzelnen Prepolymeren,
Kombination dieser einzelnen Prepolymeren in einem spezifischen Verhältnis, und
Polymerisation dieser Prepölymerenmischung unter BiI-dung
von Copolymeren.
2. Verfahren nach Anspruch 1, worin die Disäuren aus der
aus Sebacinsäure, Bis-(p-carboxyphenoxy)-propan, Bis-(p-carboxyphenoxy)-hexan, Isophthalsäure, 1,4-Phenylendipropionsäure,
Adipinsäure und Dodecandicarbonsaure bestehenden Gruppe ausgewählt werden.
3. Hochreines Anhydridcopolymeres, umfassend aus der aus aliphatischen und aromatischen Disäuren bestehenden
Gruppe ausgewählten Monomeren, wobei die Copolymere aus einer Mischung eines spezifischen Verhältnisses
von Prepolymeren der getrennt mit Essigsäureanhydrid umgesetzten, einzelnen Monomeren polymerisiert sind.
-:.-:.. ·-.-■-.' 02666U3
-2-
1
4. Anhydridcopolymeres nach Anspruch 3, worin diese Prepolymeren
durch getrenntes Rückflußkochen einzelner Monomere mit Essigsäureanhydrid unter Bildung von einzelnen
Prepolymeren,
5 Entfernen des überschüssigen Essigsäureanhydrids,
und ümkristallisation der Prepolymere gebildet sind.
10
5. Anhydridcopolymeres nach Anspruch 3, worin die Copolymere
weiterhin durch ümkristallisation gereinigt sind.
6. Anhydridcopolymeres nach Anspruch 3, worin diese Copolymeren
aus diesen Prepolymeren in Anwesenheit eines Kata-15 lysators polymerisiert sind.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/920,724 US4789724A (en) | 1986-10-17 | 1986-10-17 | Preparation of anhydride copolymers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE266603T1 true DE266603T1 (de) | 1989-02-16 |
Family
ID=25444276
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3752381T Expired - Lifetime DE3752381T2 (de) | 1986-10-17 | 1987-10-16 | Herstellung von Kopolyanhydriden |
DE198787115172T Pending DE266603T1 (de) | 1986-10-17 | 1987-10-16 | Herstellung von kopolyanhydriden. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3752381T Expired - Lifetime DE3752381T2 (de) | 1986-10-17 | 1987-10-16 | Herstellung von Kopolyanhydriden |
Country Status (7)
Country | Link |
---|---|
US (1) | US4789724A (de) |
EP (2) | EP0266603A1 (de) |
JP (1) | JP2626717B2 (de) |
KR (1) | KR960006410B1 (de) |
AT (1) | ATE285432T1 (de) |
CA (1) | CA1278141C (de) |
DE (2) | DE3752381T2 (de) |
Families Citing this family (100)
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1986
- 1986-10-17 US US06/920,724 patent/US4789724A/en not_active Expired - Lifetime
-
1987
- 1987-10-15 CA CA000549405A patent/CA1278141C/en not_active Expired - Lifetime
- 1987-10-16 EP EP87115172A patent/EP0266603A1/de not_active Ceased
- 1987-10-16 AT AT95112750T patent/ATE285432T1/de not_active IP Right Cessation
- 1987-10-16 EP EP95112750A patent/EP0692510B1/de not_active Expired - Lifetime
- 1987-10-16 DE DE3752381T patent/DE3752381T2/de not_active Expired - Lifetime
- 1987-10-16 DE DE198787115172T patent/DE266603T1/de active Pending
- 1987-10-17 KR KR1019870011521A patent/KR960006410B1/ko not_active IP Right Cessation
- 1987-10-17 JP JP62262569A patent/JP2626717B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2626717B2 (ja) | 1997-07-02 |
CA1278141C (en) | 1990-12-18 |
EP0266603A1 (de) | 1988-05-11 |
ATE285432T1 (de) | 2005-01-15 |
DE3752381D1 (de) | 2005-01-27 |
EP0692510B1 (de) | 2004-12-22 |
JPS63199227A (ja) | 1988-08-17 |
DE3752381T2 (de) | 2005-11-10 |
KR960006410B1 (ko) | 1996-05-15 |
US4789724A (en) | 1988-12-06 |
EP0692510A1 (de) | 1996-01-17 |
KR890006706A (ko) | 1989-06-15 |
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