DE2655801C2 - Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension - Google Patents

Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension

Info

Publication number
DE2655801C2
DE2655801C2 DE2655801A DE2655801A DE2655801C2 DE 2655801 C2 DE2655801 C2 DE 2655801C2 DE 2655801 A DE2655801 A DE 2655801A DE 2655801 A DE2655801 A DE 2655801A DE 2655801 C2 DE2655801 C2 DE 2655801C2
Authority
DE
Germany
Prior art keywords
membrane
solution
substances
erythrocytes
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2655801A
Other languages
German (de)
English (en)
Other versions
DE2655801A1 (de
Inventor
Karin 5100 Aachen Bock
Hermann Josef 5170 Jülich Buers
Günter Dr. 5170 Jülich Pilwat
Ulrich Prof. Dr. Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Kernforschungsanlage Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kernforschungsanlage Juelich GmbH filed Critical Kernforschungsanlage Juelich GmbH
Priority to DE2655801A priority Critical patent/DE2655801C2/de
Priority to CH1378677A priority patent/CH632927A5/de
Priority to SE7713944A priority patent/SE445294B/xx
Priority to FR7737044A priority patent/FR2373289A1/fr
Priority to GB51329/77A priority patent/GB1560165A/en
Priority to US05/859,240 priority patent/US4224313A/en
Priority to JP14732477A priority patent/JPS5372890A/ja
Priority to IL53594A priority patent/IL53594A/xx
Publication of DE2655801A1 publication Critical patent/DE2655801A1/de
Application granted granted Critical
Publication of DE2655801C2 publication Critical patent/DE2655801C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE2655801A 1976-12-09 1976-12-09 Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension Expired DE2655801C2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE2655801A DE2655801C2 (de) 1976-12-09 1976-12-09 Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension
CH1378677A CH632927A5 (de) 1976-12-09 1977-11-11 Verfahren zur herstellung einer masse von in einer physiologischen loesung suspendierten beladenen zellen.
FR7737044A FR2373289A1 (fr) 1976-12-09 1977-12-08 Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique
SE7713944A SE445294B (sv) 1976-12-09 1977-12-08 Forfarande for framstellning av en injicerbar suspension av membranvesiklar bestaende av celler fran blod
GB51329/77A GB1560165A (en) 1976-12-09 1977-12-09 Loaded cells
US05/859,240 US4224313A (en) 1976-12-09 1977-12-09 Physiological preparation containing loaded cells in suspension and an agent for counteraction of cell membrane disintegration
JP14732477A JPS5372890A (en) 1976-12-09 1977-12-09 Production of assembled substance of load cell suspended in phisiological solution
IL53594A IL53594A (en) 1976-12-09 1977-12-13 Biological cells comprising pharmaceutically active substances and additives controlling their release from the cells,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2655801A DE2655801C2 (de) 1976-12-09 1976-12-09 Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension

Publications (2)

Publication Number Publication Date
DE2655801A1 DE2655801A1 (de) 1978-06-22
DE2655801C2 true DE2655801C2 (de) 1986-06-26

Family

ID=5995087

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2655801A Expired DE2655801C2 (de) 1976-12-09 1976-12-09 Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension

Country Status (8)

Country Link
US (1) US4224313A (cg-RX-API-DMAC7.html)
JP (1) JPS5372890A (cg-RX-API-DMAC7.html)
CH (1) CH632927A5 (cg-RX-API-DMAC7.html)
DE (1) DE2655801C2 (cg-RX-API-DMAC7.html)
FR (1) FR2373289A1 (cg-RX-API-DMAC7.html)
GB (1) GB1560165A (cg-RX-API-DMAC7.html)
IL (1) IL53594A (cg-RX-API-DMAC7.html)
SE (1) SE445294B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656746C2 (de) * 1976-12-15 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verwendung von beladenen Erythrozyten
US4489162A (en) * 1981-12-21 1984-12-18 American Hospital Supply Corporation Fresh blood (unfixed) hematology control
FR2529463B1 (fr) * 1982-07-05 1986-01-10 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
US4478824A (en) * 1983-08-08 1984-10-23 Franco Robert S Method for altering red blood cell function and survival
US4610241A (en) * 1984-07-03 1986-09-09 Gordon Robert T Atherosclerosis treatment method
US4931276A (en) * 1987-10-30 1990-06-05 Franco Robert S Method for introducing desired agents into red blood cells
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US4935223A (en) * 1988-08-04 1990-06-19 Board Of Regents, The University Of Texas System Labeled cells for use in imaging
JP3054190B2 (ja) 1989-01-27 2000-06-19 イムノリティックス・インコーポレイテッド 良性前立腺肥大処置のための組成物および方法
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
US5443813A (en) * 1991-06-06 1995-08-22 Associated Universities, Inc. Loading and conjugating cavity biostructures
WO1993018397A1 (en) * 1992-03-02 1993-09-16 Streck Laboratories, Inc. Reference control for use with manual and flow cytometric reticulocyte counting devices
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) * 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
EP0882448B1 (en) * 1997-05-05 2005-01-12 DIDECO S.r.l. Method of encapsulating biologically active agents within erythrocytes and apparatus therefor
DE60026313D1 (de) 1999-07-23 2006-04-27 Uutech Ltd Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes
US20040071664A1 (en) * 1999-07-23 2004-04-15 Gendel Limited Delivery of an agent
GB9917416D0 (cg-RX-API-DMAC7.html) * 1999-07-23 1999-09-22 Univ Ulster
GB0002856D0 (en) * 2000-02-08 2000-03-29 Gendel Limited Ultrasound sensitisation
GB0025147D0 (en) * 2000-10-13 2000-11-29 Torsana Diabetes Diagnostics A Optical sensor for in situ measurement of analytes
US8986736B2 (en) * 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
US9044381B2 (en) * 2003-06-24 2015-06-02 Baxter International Inc. Method for delivering drugs to the brain
EP1713443A2 (en) * 2004-01-29 2006-10-25 Baxter International Inc. Nanosuspensions of anti-retroviral agents for increased central nervous system delivery
KR20070037444A (ko) * 2004-06-15 2007-04-04 백스터 인터내셔널 인코포레이티드 고체 미립자성 치료제의 생체외 적용방법
EP2259798B1 (en) 2008-03-05 2013-12-11 Baxter International Inc. Surface-modified particles and methods for targeted drug delivery
DE102008029172A1 (de) 2008-06-19 2009-12-24 Kenndoff, Jochen, Dr. Verfahren zum Schutz von insbesondere verletzten oder gestressten Hautbereichen einer Zitze während des Melkvorgangs
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
IT1399590B1 (it) 2010-04-26 2013-04-26 Erydel Spa Apparato e kit per incapsulare almeno un composto ad uso terapeutico e/o diagnostico all'interno di eritrociti
ITBO20100256A1 (it) * 2010-04-26 2011-10-27 Erydel Spa Metodo per incapsulare almeno un composto ad uso terapeutico e/o diagnostico all'interno di eritrociti
FR3005420B1 (fr) * 2013-05-07 2015-09-18 Erytech Pharma Procede de stabilisation de suspensions d'erythrocytes encapsulant un principe actif, suspensions obtenues.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887698A (en) * 1973-03-12 1975-06-03 Univ Leland Stanford Junior Sacs with epitopic sites on walls enclosing stable free radicals
DE2326224C3 (de) 1973-05-23 1975-11-13 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Verfahren zum Abtrenne», von durch chemische oder physikalisch^ Eigenschaften ausgezeichneten ionisierten Stoffen aus einer wäßrigen Lösung
DE2326191B2 (de) 1973-05-23 1978-03-30 Hutschenreuther Ag, 8672 Selb Verfahren zum Herstellen eines Reliefdekors auf keramischen Erzeugnissen
DE2326161C2 (de) 1973-05-23 1986-07-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zum Aufbau oder zum Abbau von durch chemische Eigenschaften ausgezeichneten, in einer wäßrigen Lösung enthaltenen Stoffen
GB1481480A (en) * 1974-02-02 1977-07-27 Kernforschungsanlage Juelich Process and apparatus for increasing the permeability of the membrane of cells of organisms
DE2656746C2 (de) * 1976-12-15 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verwendung von beladenen Erythrozyten

Also Published As

Publication number Publication date
SE445294B (sv) 1986-06-16
JPS5372890A (en) 1978-06-28
FR2373289A1 (fr) 1978-07-07
CH632927A5 (de) 1982-11-15
SE7713944L (sv) 1978-06-10
US4224313A (en) 1980-09-23
DE2655801A1 (de) 1978-06-22
FR2373289B1 (cg-RX-API-DMAC7.html) 1981-05-29
IL53594A (en) 1981-06-29
GB1560165A (en) 1980-01-30

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Legal Events

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OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee