DE2601137A1 - Substituierte perhalogenalkylamidine und herzstimulantien - Google Patents

Substituierte perhalogenalkylamidine und herzstimulantien

Info

Publication number
DE2601137A1
DE2601137A1 DE19762601137 DE2601137A DE2601137A1 DE 2601137 A1 DE2601137 A1 DE 2601137A1 DE 19762601137 DE19762601137 DE 19762601137 DE 2601137 A DE2601137 A DE 2601137A DE 2601137 A1 DE2601137 A1 DE 2601137A1
Authority
DE
Germany
Prior art keywords
alkyl
radical
substituted
phenyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19762601137
Other languages
German (de)
English (en)
Inventor
Walfred Spencer Saari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2601137A1 publication Critical patent/DE2601137A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE19762601137 1975-01-15 1976-01-14 Substituierte perhalogenalkylamidine und herzstimulantien Pending DE2601137A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54130875A 1975-01-15 1975-01-15
US62973575A 1975-11-10 1975-11-10

Publications (1)

Publication Number Publication Date
DE2601137A1 true DE2601137A1 (de) 1976-07-22

Family

ID=27066677

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762601137 Pending DE2601137A1 (de) 1975-01-15 1976-01-14 Substituierte perhalogenalkylamidine und herzstimulantien

Country Status (21)

Country Link
JP (1) JPS51125202A (fr)
AR (1) AR213168A1 (fr)
AU (1) AU499649B2 (fr)
BG (1) BG25074A3 (fr)
CS (1) CS189737B2 (fr)
DD (1) DD124598A5 (fr)
DE (1) DE2601137A1 (fr)
DK (1) DK593975A (fr)
ES (1) ES444259A1 (fr)
FI (1) FI753673A (fr)
FR (1) FR2297615A1 (fr)
GB (1) GB1490671A (fr)
IL (1) IL48784A0 (fr)
LU (1) LU74170A1 (fr)
NL (1) NL7515256A (fr)
NO (1) NO754426L (fr)
NZ (1) NZ179730A (fr)
PL (1) PL101099B1 (fr)
PT (1) PT64673B (fr)
SE (1) SE7514776L (fr)
SU (1) SU633471A3 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423246A (en) * 1982-02-22 1983-12-27 Olin Corporation Selected trichloroacetamidines
US4709052A (en) * 1983-05-31 1987-11-24 Sumitomo Chemical Company, Limited Soil disease-controlling imides
US4774248A (en) * 1985-12-13 1988-09-27 Societe Anonyme Dite: Laboratoire L. Lafon Methods of treating depression and depressive states using 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
WO1996019440A1 (fr) * 1994-12-20 1996-06-27 The Wellcome Foundation Limited Derives d'acetamidine et leur utilisation comme inhibiteurs de no synthetase

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004054A1 (fr) * 1990-08-30 1992-03-19 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Amidines substituees ayant une forte affinite avec le recepteur sigma et utilisations desdites amidines
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
EP1586561A1 (fr) * 2004-04-13 2005-10-19 Cephalon, Inc. Dérivés bicycliques aromatiques de sulfinyle
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
AU2008251476B2 (en) 2007-05-10 2014-06-12 Plastipak Packaging, Inc. Oxygen scavenging molecules, articles containing same, and methods of their use
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
PL2483342T3 (pl) 2009-09-29 2017-08-31 Plastipak Packaging, Inc. Kompozycje kompatybilnego ze środkiem barwiącym polimeru zmiatającego tlen i wykonane z nich wyroby
AU2010319298B2 (en) 2009-11-13 2015-11-05 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
CA2780768C (fr) 2009-11-13 2019-01-15 Constar International, Inc. Laveurs d'oxygene, composition comprenant les laveurs, et articles realises a partir des compositions
RU2640536C2 (ru) 2012-04-30 2018-01-09 Пластипэк Пэкэджинг Инк. Композиции поглотителя кислорода
US11338983B2 (en) 2014-08-22 2022-05-24 Plastipak Packaging, Inc. Oxygen scavenging compositions, articles containing same, and methods of their use
US10351692B2 (en) 2014-10-17 2019-07-16 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423246A (en) * 1982-02-22 1983-12-27 Olin Corporation Selected trichloroacetamidines
US4709052A (en) * 1983-05-31 1987-11-24 Sumitomo Chemical Company, Limited Soil disease-controlling imides
US4774248A (en) * 1985-12-13 1988-09-27 Societe Anonyme Dite: Laboratoire L. Lafon Methods of treating depression and depressive states using 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
WO1996019440A1 (fr) * 1994-12-20 1996-06-27 The Wellcome Foundation Limited Derives d'acetamidine et leur utilisation comme inhibiteurs de no synthetase
US5866612A (en) * 1994-12-20 1999-02-02 Glaxo Wellcome Inc. Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase
USRE37438E1 (en) 1994-12-20 2001-11-06 Glaxo Wellcome Inc. Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase

Also Published As

Publication number Publication date
NO754426L (fr) 1976-07-16
DK593975A (da) 1976-07-16
DD124598A5 (fr) 1977-03-02
BG25074A3 (en) 1978-07-12
AU499649B2 (en) 1979-04-26
CS189737B2 (en) 1979-04-30
SU633471A3 (ru) 1978-11-15
FI753673A (fr) 1976-07-16
SE7514776L (sv) 1976-07-16
LU74170A1 (fr) 1976-12-31
AR213168A1 (es) 1978-12-29
PL101099B1 (pl) 1978-11-30
NZ179730A (en) 1978-07-10
NL7515256A (nl) 1976-07-19
GB1490671A (en) 1977-11-02
FR2297615A1 (fr) 1976-08-13
PT64673B (fr) 1978-01-04
IL48784A0 (en) 1976-03-31
JPS51125202A (en) 1976-11-01
PT64673A (fr) 1976-02-01
ES444259A1 (es) 1977-10-01
AU1006076A (en) 1977-07-14

Similar Documents

Publication Publication Date Title
DE2601137A1 (de) Substituierte perhalogenalkylamidine und herzstimulantien
DE2017255A1 (de) 1-substituierte-3-Pheny!pyrrolidine und Verfahren zu deren Herstellung
EP0136658B1 (fr) -1-Benzyl-aminoalkyl-pyrrolidinones et leurs sels d'addition, procédé de préparation et médicaments les contenant
DE2952279A1 (de) Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2724989A1 (de) Guanidinderivate, verfahren zu ihrer herstellung und arzneimittel
EP1558583A1 (fr) Derives phenylethanolamine et utilisation en tant que beta-3-agonistes
DD235256A5 (de) Verfahren zur herstellung neuer substituierter pyrrolidinone
DD202433A5 (de) Verfahren zur herstellung von amidobenzamiden
DE68916198T2 (de) Carbamoyl-2-Pyrrolidinonverbindungen.
DE3439450A1 (de) 1,2,4-triazolo-carbamate und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE69215482T2 (de) 2,2'-Alkylendiindolderivate, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Verwendung als Ulcustherapeutikum
EP0346683A1 (fr) Dérivés de pyrrole, leur préparation et leur utilisation comme agents pharmaceutiques
DE1964282A1 (de) Imidazoliumsalze und Verfahren zu deren Herstellung
DE2017256A1 (de) l-Carbamoyl-3-pheny!pyrrolidine und Verfahren zu deren Herstellung
DE2653147C2 (fr)
DE69526413T2 (de) Heterocyclische Carboxyalkylderivate
DE2161827A1 (de) l-(3-Cyano-3,3-diphenylpropyl-)4phenylpiperidinderivate und Verfahren zu ihrer Herstellung
EP0068240B1 (fr) Acylaminométhyl-2-benzodiazépines-1,4, leur préparation et produits intermédiaires et produit pharmaceutiques qui les contiennent
DD232696A5 (de) Neue amidinderivate 2-substituierter 4-phenylimidazole
DE3026365A1 (de) Neue tetrahydropyridin-4-yl-indol- derivate und deren salze, ihre herstellung, ihre verwendung als arzneimittel und die sie enthaltenden zusammensetzungen
CH666035A5 (de) 8-alpha-acylaminoergolene.
DE2601158A1 (de) Herzstimulantien
EP0287988A2 (fr) Aldéhydes de pyrrole, leur préparation et utilisation
DD201594A5 (de) Verfahren zur herstellung von neuen polyazaheterocyclischen verbindungen
DD202288A5 (de) Verfahren zur herstellung von phenylpiperazinderivaten

Legal Events

Date Code Title Description
OHJ Non-payment of the annual fee