IL48784A0 - Novel substituted perhaloalkylamidines,their preparation and use as cardiac stimulants - Google Patents

Novel substituted perhaloalkylamidines,their preparation and use as cardiac stimulants

Info

Publication number
IL48784A0
IL48784A0 IL48784A IL4878476A IL48784A0 IL 48784 A0 IL48784 A0 IL 48784A0 IL 48784 A IL48784 A IL 48784A IL 4878476 A IL4878476 A IL 4878476A IL 48784 A0 IL48784 A0 IL 48784A0
Authority
IL
Israel
Prior art keywords
perhaloalkylamidines
preparation
novel substituted
cardiac stimulants
stimulants
Prior art date
Application number
IL48784A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL48784A0 publication Critical patent/IL48784A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
IL48784A 1975-01-15 1976-01-05 Novel substituted perhaloalkylamidines,their preparation and use as cardiac stimulants IL48784A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54130875A 1975-01-15 1975-01-15
US62973575A 1975-11-10 1975-11-10

Publications (1)

Publication Number Publication Date
IL48784A0 true IL48784A0 (en) 1976-03-31

Family

ID=27066677

Family Applications (1)

Application Number Title Priority Date Filing Date
IL48784A IL48784A0 (en) 1975-01-15 1976-01-05 Novel substituted perhaloalkylamidines,their preparation and use as cardiac stimulants

Country Status (21)

Country Link
JP (1) JPS51125202A (fr)
AR (1) AR213168A1 (fr)
AU (1) AU499649B2 (fr)
BG (1) BG25074A3 (fr)
CS (1) CS189737B2 (fr)
DD (1) DD124598A5 (fr)
DE (1) DE2601137A1 (fr)
DK (1) DK593975A (fr)
ES (1) ES444259A1 (fr)
FI (1) FI753673A (fr)
FR (1) FR2297615A1 (fr)
GB (1) GB1490671A (fr)
IL (1) IL48784A0 (fr)
LU (1) LU74170A1 (fr)
NL (1) NL7515256A (fr)
NO (1) NO754426L (fr)
NZ (1) NZ179730A (fr)
PL (1) PL101099B1 (fr)
PT (1) PT64673B (fr)
SE (1) SE7514776L (fr)
SU (1) SU633471A3 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423246A (en) 1982-02-22 1983-12-27 Olin Corporation Selected trichloroacetamidines
US4709052A (en) * 1983-05-31 1987-11-24 Sumitomo Chemical Company, Limited Soil disease-controlling imides
DE3664768D1 (en) * 1985-12-13 1989-09-07 Lafon Labor 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, preparation process and medicinal use
EP0551330A4 (en) * 1990-08-30 1994-07-06 Oregon State Substituted amidines having high binding to the sigma receptor and the use thereof
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US7423176B2 (en) * 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1586561A1 (fr) * 2004-04-13 2005-10-19 Cephalon, Inc. Dérivés bicycliques aromatiques de sulfinyle
CN104017241B (zh) 2007-05-10 2017-09-05 塑料包装有限公司 氧清除分子、包含所述氧清除分子的制品及其使用方法
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
WO2011043969A2 (fr) 2009-09-29 2011-04-14 Constar International Compositions de polymère inactiveur d'oxygène compatibles avec un colorant et articles fabriqués à partir de celles-ci
CA2780749A1 (fr) 2009-11-13 2011-05-19 Constar International, Inc. Laveurs d'oxygene, compositions comprenant les laveurs, et articles realises a partir des compositions
ES2668080T3 (es) 2009-11-13 2018-05-16 Plastipak Packaging, Inc. Depuradores de oxígeno, composición que comprende los depuradores y artículos producidos a partir de las composiciones
MY178028A (en) 2012-04-30 2020-09-29 Plastipak Packaging Inc Oxygen scavenging compositions
US11338983B2 (en) 2014-08-22 2022-05-24 Plastipak Packaging, Inc. Oxygen scavenging compositions, articles containing same, and methods of their use
US10351692B2 (en) 2014-10-17 2019-07-16 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
CN117756628A (zh) * 2023-12-29 2024-03-26 江苏兄弟维生素有限公司 利用氨基嘧啶母液游离盐酸乙脒并联产甲酸甲酯的方法

Also Published As

Publication number Publication date
SU633471A3 (ru) 1978-11-15
DK593975A (da) 1976-07-16
PT64673A (fr) 1976-02-01
SE7514776L (sv) 1976-07-16
AR213168A1 (es) 1978-12-29
ES444259A1 (es) 1977-10-01
NO754426L (fr) 1976-07-16
FR2297615A1 (fr) 1976-08-13
CS189737B2 (en) 1979-04-30
PT64673B (fr) 1978-01-04
PL101099B1 (pl) 1978-11-30
JPS51125202A (en) 1976-11-01
DE2601137A1 (de) 1976-07-22
GB1490671A (en) 1977-11-02
LU74170A1 (fr) 1976-12-31
DD124598A5 (fr) 1977-03-02
BG25074A3 (en) 1978-07-12
NL7515256A (nl) 1976-07-19
AU1006076A (en) 1977-07-14
NZ179730A (en) 1978-07-10
AU499649B2 (en) 1979-04-26
FI753673A (fr) 1976-07-16

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