DE2558150A1 - Neue benzylpyrimidine - Google Patents

Neue benzylpyrimidine

Info

Publication number
DE2558150A1
DE2558150A1 DE19752558150 DE2558150A DE2558150A1 DE 2558150 A1 DE2558150 A1 DE 2558150A1 DE 19752558150 DE19752558150 DE 19752558150 DE 2558150 A DE2558150 A DE 2558150A DE 2558150 A1 DE2558150 A1 DE 2558150A1
Authority
DE
Germany
Prior art keywords
bis
diamino
dimethylamino
amino
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19752558150
Other languages
German (de)
English (en)
Inventor
Ivan Dr Kompis
Gerald Dr Rey-Bellet
Guido Dr Zanetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2558150A1 publication Critical patent/DE2558150A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
DE19752558150 1974-12-24 1975-12-23 Neue benzylpyrimidine Ceased DE2558150A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1728774A CH605828A5 (is) 1974-12-24 1974-12-24

Publications (1)

Publication Number Publication Date
DE2558150A1 true DE2558150A1 (de) 1976-07-01

Family

ID=4424233

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752558150 Ceased DE2558150A1 (de) 1974-12-24 1975-12-23 Neue benzylpyrimidine

Country Status (25)

Country Link
JP (1) JPS5191273A (is)
AT (1) AT344704B (is)
AU (1) AU500102B2 (is)
BE (1) BE836996A (is)
BR (1) BR7508534A (is)
CA (1) CA1059127A (is)
CH (2) CH605828A5 (is)
CU (1) CU34406A (is)
DD (1) DD123603A5 (is)
DE (1) DE2558150A1 (is)
DK (1) DK137797B (is)
ES (1) ES443790A1 (is)
FI (1) FI753312A (is)
FR (1) FR2295750A1 (is)
GB (1) GB1492140A (is)
HU (1) HU174324B (is)
IL (1) IL48416A (is)
LU (1) LU73971A1 (is)
NL (1) NL7514269A (is)
NO (1) NO141408C (is)
PH (1) PH12314A (is)
PL (1) PL101046B1 (is)
SE (1) SE417607B (is)
SU (1) SU612629A3 (is)
ZA (1) ZA756964B (is)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003212A1 (de) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidine und diese enthaltende pharmazeutische Präparate sowie deren Herstellung

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9567318B2 (en) * 2009-08-17 2017-02-14 Memorial Sloan-Kettering Cancer Center Substituted pyrimidine compounds and uses thereof
JP6607870B2 (ja) 2014-05-13 2019-11-20 メモリアル スローン ケタリング キャンサー センター Ｈｓｐ７０モジュレーターならびにその作製および使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003212A1 (de) * 1977-11-10 1979-08-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 2.4-Diamino-5-benzylpyrimidine und diese enthaltende pharmazeutische Präparate sowie deren Herstellung
EP0032395B1 (de) * 1977-11-10 1983-03-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzylpyrimidine

Also Published As

Publication number Publication date
SU612629A3 (ru) 1978-06-25
DK137797C (is) 1978-10-16
IL48416A (en) 1980-02-29
NL7514269A (nl) 1976-06-28
CU34406A (es) 1978-09-08
BE836996A (fr) 1976-06-23
ES443790A1 (es) 1977-12-16
SE417607B (sv) 1981-03-30
PL101046B1 (pl) 1978-11-30
CH605828A5 (is) 1978-10-13
SE7514642L (sv) 1976-06-28
ZA756964B (en) 1976-10-27
ATA975975A (de) 1977-12-15
IL48416A0 (en) 1976-01-30
JPS5191273A (is) 1976-08-10
DD123603A5 (is) 1977-01-05
NO141408C (no) 1980-03-05
PH12314A (en) 1979-01-16
FR2295750A1 (fr) 1976-07-23
HU174324B (hu) 1979-12-28
AT344704B (de) 1978-08-10
DK137797B (da) 1978-05-08
NO754372L (is) 1976-06-25
CH617191A5 (en) 1980-05-14
DK589675A (is) 1976-06-25
FI753312A (is) 1976-06-25
BR7508534A (pt) 1976-12-21
FR2295750B1 (is) 1980-06-20
LU73971A1 (is) 1977-07-01
NO141408B (no) 1979-11-26
GB1492140A (en) 1977-11-16
CA1059127A (en) 1979-07-24
AU8643375A (en) 1977-05-12
AU500102B2 (en) 1979-05-10

Similar Documents

Publication Publication Date Title
DE69129611T2 (de) Sulfonamid-Derivate
DE69831233T2 (de) Barbitursaure derivaten mit antimetastatischer und antitumorischer wirkung
DE3876813T4 (de) 3(2H)Pyridazinon, Verfahren zu dessen Herstellung und dieses enthaltendes Mittel gegen SRS-A.
DE2905877A1 (de) Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE1185180B (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US4039543A (en) Benzylpyrimidines
US4659818A (en) Intermediates for benzylpyrimidines
EP0154885B1 (de) Substituierte 2-Phenyl-hexahydro-1,2,4-triazin-3,5-dione, Verfahren zu ihrer Herstellung, ihre Verwendung als Tierarzneimittel und zur Bekämpfung von Protozoen
EP0239907B1 (de) Neue Phenoxyalkylcarbonsäure-Derivate, Verfahren zu ihrer Herstellung, sowie diese Verbindungen enthaltende Arzneimittel
EP0165422B1 (de) Neue substituierte Bis(4-aminophenyl)sulfone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE2731264A1 (de) Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen
JPH0434545B2 (is)
DE3830060A1 (de) 2-phenylbenzimidazole - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE2443682C2 (de) Neue 2,4-Diamino-5-benzylpyrimidine
UA44237C2 (uk) Арилбензоїлгуанідини, спосіб їх отримання, фармацевтична композиція
DE2558150A1 (de) Neue benzylpyrimidine
DE2452889C2 (de) Neue Benzylpyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3781703T2 (de) 2-benzimidazolylalkylthio(oder sulfinyl- oder sulfonyl)-derivate, verfahren zu deren herstellung und deren anwendung als arzneimittel.
EP0003212B1 (de) 2.4-Diamino-5-benzylpyrimidine und diese enthaltende pharmazeutische Präparate sowie deren Herstellung
DE69713128T2 (de) 4-(1-piperazinyl)benzosäurederivate, verfahren zu ihrer herstellung und ihre therapeutischen verwendungen
DE2526795A1 (de) Sulfonamide
DE3804346A1 (de) Tert.-butylphenyl-pyridyl-amide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE2643384A1 (de) Neue 5,6-dihydropyrimidin-4(3h)-onderivate, verfahren zu ihrer herstellung und ihre verwendung als wirkstoff in pharmazeutischen praeparaten
DE2409313A1 (de) Neue pyrrolyl-verbindungen und verfahren zu ihrer herstellung
DE2435934A1 (de) Neue benzylpyrimidine

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection