DE2530221A1 - Zwischenprodukte zur herstellung von prostaglandin-analoga und verfahren zu ihrer herstellung - Google Patents

Zwischenprodukte zur herstellung von prostaglandin-analoga und verfahren zu ihrer herstellung

Info

Publication number
DE2530221A1
DE2530221A1 DE19752530221 DE2530221A DE2530221A1 DE 2530221 A1 DE2530221 A1 DE 2530221A1 DE 19752530221 DE19752530221 DE 19752530221 DE 2530221 A DE2530221 A DE 2530221A DE 2530221 A1 DE2530221 A1 DE 2530221A1
Authority
DE
Germany
Prior art keywords
carbon atoms
radical
formula
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19752530221
Other languages
German (de)
English (en)
Inventor
Jun Douglas Ross Morton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE2530221A1 publication Critical patent/DE2530221A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
DE19752530221 1974-07-12 1975-07-07 Zwischenprodukte zur herstellung von prostaglandin-analoga und verfahren zu ihrer herstellung Withdrawn DE2530221A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48829574A 1974-07-12 1974-07-12
US55270775A 1975-02-24 1975-02-24

Publications (1)

Publication Number Publication Date
DE2530221A1 true DE2530221A1 (de) 1976-01-29

Family

ID=27049301

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752530221 Withdrawn DE2530221A1 (de) 1974-07-12 1975-07-07 Zwischenprodukte zur herstellung von prostaglandin-analoga und verfahren zu ihrer herstellung

Country Status (6)

Country Link
JP (1) JPS5134146A (enExample)
CH (2) CH619922A5 (enExample)
DE (1) DE2530221A1 (enExample)
FR (3) FR2285385A1 (enExample)
GB (3) GB1482049A (enExample)
NL (1) NL7508301A (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029681A (en) * 1976-02-13 1977-06-14 The Upjohn Company 13,14-Didehydro-PG analogs

Also Published As

Publication number Publication date
FR2285364B1 (enExample) 1980-07-18
FR2285385A1 (fr) 1976-04-16
JPS5134146A (ja) 1976-03-23
NL7508301A (nl) 1976-01-14
FR2285385B1 (enExample) 1979-03-09
GB1482048A (en) 1977-08-03
CH619922A5 (en) 1980-10-31
FR2285373B1 (enExample) 1980-07-18
GB1482047A (en) 1977-08-03
FR2285364A1 (fr) 1976-04-16
FR2285373A1 (fr) 1976-04-16
AU8243775A (en) 1977-01-06
GB1482049A (en) 1977-08-03
CH615923A5 (en) 1980-02-29

Similar Documents

Publication Publication Date Title
DE3153390C2 (enExample)
CH626337A5 (enExample)
DE2704933A1 (de) Prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14 und verfahren zu ihrer herstellung
CH625797A5 (enExample)
CH628884A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga.
AT367747B (de) Verfahren zur herstellung von optisch aktiven oder racemischen prostaglandinen und ihren salzen
DE2732107C2 (de) Verfahren zur Herstellung von cyclischen Ketoessigsäureestern
DE2726857A1 (de) 9 alpha, 11 alpha-epoxymethano- oder 11 alpha, 9 alpha-epoxymethano-9, 11,15-trideoxy-prostaglandin f-analoga
DE2539116C2 (de) ω-Nor-cycloalkyl-13,14-dehydro-prostaglandine, Verfahren zu ihrer Herstellung sowie sie enthaltende pharmazeutische Mittel
DE2610718A1 (de) Neue 16-phenoxy-prostaglandin-verbindungen
DE3789064T2 (de) Verfahren zur Herstellung von in Stellung 3 durch eine halogenierte gesättigte Kette substituierten Cyclopropancarbonsäurederivaten.
DE2533387C2 (de) Verfahren zur Herstellung von 2-Hydroxy-3-butensäureestern
DE68910774T2 (de) Cyclopentanheptencarbonsäurederivate und Verfahren zu ihrer Herstellung.
DE2509415C2 (de) Verfahren zur Herstellung von 2-Acyl-3-substituierten Cyclopentan-1-onen, bestimmte 2-Acyl-3-substituierte Cyclopentan-1-one als solche und Arzneimittel, welche die letzteren enthalten
DE2560629C2 (de) Verfahren zur Herstellung substituierter 2-Hydroxybutensäureester und einige 2-Hydroxybutensäureester als solche
US3281440A (en) Fluorinated vitamin a compounds
US4107181A (en) Useful prostaglandin intermediates
EP0182168B1 (de) Verfahren zur Herstellung von Hydroxymethylen-alkoxyessigsäureestern
DE2654668A1 (de) Verfahren zur herstellung von verbindungen des prostaglandintyps und nach diesem verfahren erhaltene produkte
DE2523695B2 (de) Verfahren zur herstellung von bicyclischen gamma-lactonen
EP0008077B1 (de) Neue Prostaglandinderivate in der Delta-2-PGF2 und Delta-2-PGE2-Reihe, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
EP0529444B1 (de) 2-Arylpropensäuren und ihre Verwendung bei der Herstellung von S-Ketoprofen
DE2602508A1 (de) Aliphatische carbonylverbindungen
DE2704958A1 (de) Prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14 und verfahren zu ihrer herstellung
DE2703471A1 (de) Zwischenprodukte zur herstellung, von prostaglandinen und prostaglandinanaloga und verfahren zu deren herstellung

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8130 Withdrawal