DE2455859A1 - Verfahren zur herstellung neuer antibiotika - Google Patents

Verfahren zur herstellung neuer antibiotika

Info

Publication number
DE2455859A1
DE2455859A1 DE19742455859 DE2455859A DE2455859A1 DE 2455859 A1 DE2455859 A1 DE 2455859A1 DE 19742455859 DE19742455859 DE 19742455859 DE 2455859 A DE2455859 A DE 2455859A DE 2455859 A1 DE2455859 A1 DE 2455859A1
Authority
DE
Germany
Prior art keywords
new
strain
new antibiotics
antibiotics
pers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19742455859
Other languages
English (en)
Other versions
DE2455859C2 (de
Inventor
Eugen Haerri
Artur Rueegger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25713544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2455859(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH1711173A external-priority patent/CH589716A5/de
Priority claimed from CH1404374A external-priority patent/CH603790A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of DE2455859A1 publication Critical patent/DE2455859A1/de
Application granted granted Critical
Publication of DE2455859C2 publication Critical patent/DE2455859C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/06—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Description

509 824/0985
Tabelle
Case 100-4106
JC-Spektrendaten von S 7481/F-l; 250 xg ir. 1,5 &l CDCl ^ , r r ρ C. Q
Bruker HX-9OE; Sweep-width 6θΟΟΗζ
Iresse Frequenz [Hz] c S [ppmj
1260 39 15.52 73 173.0237
1264 3909.5679 72.7648
1293 3867.15 75 70-3876
1299 335S.3984 70.4992
1312 3839.3554 69.6577
I 31 7 3332.13312 169.3341
1937 2923.S2SI 129-2014
1992 2843 .2617 25.6412
2745 1740.2343 76-399 4
2785 1681 .6406 74-31x52
3027 1327- 1484 58 -6455
3042 1305.1757 57.6745
304 7 1297-3 515 57.3509
3.G 51 1291 .9921 57.0920
3SSl 124S.0468 55.1501
3159 1133.7S9P 50. 101 I
31S4. 1097· 1679 48 .4828
3189 1089. S437 48- 1592
3239 10 I 6 . 601 5 44.9227
33J35 919-9218 4P .65J35
3327 837.5953 39.2264
3332 330.371.0 33 .902 3
3357 843.75.^.0 37.2845
3363 8 34.9609 36.8961
3380 810.£5S5 35.7957
3387 79? .S.C746 35.3426
341 1 7 64.64S4 33.7891
3449 7j33 .98 43 31 .3294
3454 70 I . 66Cf I 31 ..0057
3475 67Ö.S9S4 29-6464
3478 66S.5u39 29-4522
3436 654.7S5J 28 .9343
3543 571 .2S9C 25.2447
3549 562.SCS0 24.8563
35 53 556.6406 24.5974
3566 537.59 76 23.7559
3574 525.5739 23.2381
3582 514 . 160 I 22.7202
3596 49 3.6523 21 .6140
3607 4 77.5390 21 .1020
3622 455.5664 20.1310
3628 446.7773 19.7427
3645 42 1 .875.0 18 .6422
365/3 414.55p? 18 .3186
3654 408.6914 18-0597
3653 402.832,0 1 7.8J007
3574 379-3945 If .7651
36SS 353.8367 15.8 588
37Sl 222.6562 9.8389
3933 p.apcö 0.0000
Intensität
184 192
215 207 268 220 225
20 165 187 223 253
4P* 344
1 72 566
2 76 206 158 192 222 167
3.3 * 567
132 167 518 544 179 310 237 631 843
762 S3*
231 165 254. 285 314 2 78 277 224; 2.Ö2 139 1 I I
= Tetramethylsilan
•Registrierte Signale von CDC1_ und höheren Rauschspitzen
509824/0985 BAD ORIGINAL
Leerseite
■> ■:·, '. ■ ■-.

Claims (7)

- 20 - Case 100-4106 Patentansprüche:
1. Die neuen Antibiotika S 7481/F-l und S 7481/F-2.
2. Verfahren zur Herstellung der neuen Antibiotika
S 7481/F-l und S 7481/F-2, dadurch gekennzeichnet, dass man einen neuen Stamm der Pilzspe.cies Cylindrocarpon lucidum Booth bzw. der Pilzspecies Trichoderma polysporum (Link ex Pers.) oder eine ihrer Mutanten auf oder in einem Nährmedium züchtet und hierauf die neuen Antibiotika S 7481/F-l und S 7481/F-2 nach an sich bekannten Methoden aus dem Nährmedium isoliert und reinigt.
3. Verfahren nach Anspruch 2, dadurch gekennzeichnet, dass man als neuen Stamm der Pilzspecies Cylindrocarpon lucidum Booth den Stamm NRRL 5760 verwendet.
4. Verfahren nach Anspruch 2, dadurch gekennzeichnet, dass man als neuen Stamm der Pilzspecies Trichoderma polysporum (Link ex Pers.) den Stamm NRRL 8044 verwendet .
5. Ein die neuen Antibiotika S 7481/F-l und S 7481/F-2 produzierender Stamm der Pilzspecies Cylindrocarpon lucidum Booth oder eine seiner Mutanten.
6. Ein die neuen Antibiotika S 7481/F-l und S 7481/F-2 produzierender Stamm der Pilzspecies Trichoderma polysporum (Link ex Pers.) oder eine seiner Mutanten,
509824/0985
Case 100-4106
7. Heilmittel/ dadurch gekennzeichnet, dass es das neue Antibiotikum S 7481/F-l oder S 7481/F-2 enthält.
3700/BA/ER
SANDOZ^ PATENT-GMBH
DE2455859A 1973-12-06 1974-11-26 Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung Expired DE2455859C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1711173A CH589716A5 (en) 1973-12-06 1973-12-06 Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant
CH1404374A CH603790A5 (en) 1974-10-21 1974-10-21 Antibiotics S 7481-F-1 and 2

Publications (2)

Publication Number Publication Date
DE2455859A1 true DE2455859A1 (de) 1975-06-12
DE2455859C2 DE2455859C2 (de) 1983-12-15

Family

ID=25713544

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2455859A Expired DE2455859C2 (de) 1973-12-06 1974-11-26 Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
DE2463138A Expired DE2463138C2 (de) 1973-12-06 1974-11-26 Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2463138A Expired DE2463138C2 (de) 1973-12-06 1974-11-26 Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung

Country Status (19)

Country Link
JP (1) JPS5615235B2 (de)
AU (1) AU500889B2 (de)
CA (1) CA1030469A (de)
DD (1) DD115695A5 (de)
DE (2) DE2455859C2 (de)
DK (1) DK136780B (de)
ES (1) ES432559A1 (de)
FI (2) FI52851C (de)
FR (1) FR2253531B1 (de)
GB (1) GB1491509A (de)
HK (1) HK53880A (de)
IE (1) IE40549B1 (de)
IL (1) IL46180A (de)
MY (1) MY8100203A (de)
NL (1) NL179220C (de)
NO (1) NO744292L (de)
NZ (1) NZ176117A (de)
PH (1) PH13773A (de)
SE (1) SE423720B (de)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4108985A (en) 1975-11-04 1978-08-22 Sandoz Ltd. Dihydrocyclosporin c
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US5079341A (en) * 1987-07-22 1992-01-07 Galpin Ian J Cyclosporins
LT4306B (lt) 1994-11-03 1998-03-25 Novartis Ag Naujos peroralinio vartojimo ciklosporino kompozicijos, turinčios paprastą sudėtį ir didelį bioprieinamumą ir jų gavimo būdas
US6423233B1 (en) 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
WO2010012786A1 (de) * 2008-07-29 2010-02-04 Sandoz Ag Verfahren zur aufarbeitung von mikrobiologisch hergestellten zyklischen oligopeptiden
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4384996A (en) 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
FI111730B (fi) 1990-11-02 2003-09-15 Novartis Ag Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
ATE158022T1 (de) * 1991-01-25 1997-09-15 Fujisawa Pharmaceutical Co Prozess zur produktion von cyclosporin-a und/oder c
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Akt.rheumatol. 4, 1979, S. 173-186 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2648121C2 (de) 1975-11-04 1986-05-28 Sandoz-Patent-GmbH, 7850 Lörrach Dihydro-cyclosporin C, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
DE2661031C2 (de) * 1975-11-04 1988-05-05 Sandoz-Patent-Gmbh, 7850 Loerrach, De
US4108985A (en) 1975-11-04 1978-08-22 Sandoz Ltd. Dihydrocyclosporin c
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US5079341A (en) * 1987-07-22 1992-01-07 Galpin Ian J Cyclosporins
LT4306B (lt) 1994-11-03 1998-03-25 Novartis Ag Naujos peroralinio vartojimo ciklosporino kompozicijos, turinčios paprastą sudėtį ir didelį bioprieinamumą ir jų gavimo būdas
US6706192B2 (en) 1997-03-25 2004-03-16 Biogal Gyogyszergyar Rt. Purification process
US6423233B1 (en) 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7632807B2 (en) 2004-10-06 2009-12-15 Albany Molecular Research, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2010012786A1 (de) * 2008-07-29 2010-02-04 Sandoz Ag Verfahren zur aufarbeitung von mikrobiologisch hergestellten zyklischen oligopeptiden
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
US8691770B2 (en) 2008-07-29 2014-04-08 Sandoz Ag Method for processing microbiologically produced cyclic oligopeptides

Also Published As

Publication number Publication date
IL46180A0 (en) 1975-03-13
FI54606B (fi) 1978-09-29
FI771201A7 (de) 1977-04-15
MY8100203A (en) 1981-12-31
IL46180A (en) 1978-07-31
NL179220C (nl) 1986-08-01
FI54606C (fi) 1979-01-10
SE423720B (sv) 1982-05-24
AU500889B2 (en) 1979-06-07
FR2253531B1 (de) 1978-07-21
IE40549L (en) 1975-06-06
GB1491509A (en) 1977-11-09
FR2253531A1 (de) 1975-07-04
AU7608174A (en) 1976-06-10
ES432559A1 (es) 1977-03-01
PH13773A (en) 1980-09-23
FI52851C (fi) 1977-12-12
CA1030469A (en) 1978-05-02
DK136780B (da) 1977-11-21
NL7415682A (nl) 1975-06-10
HK53880A (en) 1980-10-03
NO744292L (de) 1975-06-30
FI343474A7 (de) 1975-06-07
IE40549B1 (en) 1979-06-20
JPS5089598A (de) 1975-07-18
DE2455859C2 (de) 1983-12-15
FI52851B (de) 1977-08-31
SE7415027L (de) 1975-06-09
DK617074A (de) 1975-07-28
NZ176117A (en) 1981-05-01
JPS5615235B2 (de) 1981-04-09
DK136780C (de) 1978-05-01
DD115695A5 (de) 1975-10-12
NL179220B (nl) 1986-03-03
DE2463138C2 (de) 1984-07-05

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