IE40549L - Metabolites s7481/f-1 and/f-2 - Google Patents
Metabolites s7481/f-1 and/f-2Info
- Publication number
- IE40549L IE40549L IE742502A IE250274A IE40549L IE 40549 L IE40549 L IE 40549L IE 742502 A IE742502 A IE 742502A IE 250274 A IE250274 A IE 250274A IE 40549 L IE40549 L IE 40549L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- see
- decomp
- nrrl
- dec
- Prior art date
Links
- 239000002207 metabolite Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 241000875119 Cylindrocarpon lucidum Species 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 2
- 238000002844 melting Methods 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 2
- 238000002211 ultraviolet spectrum Methods 0.000 abstract 2
- 241001149960 Tolypocladium inflatum Species 0.000 abstract 1
- 241001144069 Tolypocladium inflatum NRRL8044 Species 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
- C07K4/06—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/885—Trichoderma
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Alternative & Traditional Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1491509 Antibiotics SANDOZ Ltd 2 Dec 1974 [6 Dec 1973 21 Oct 1974] 52013/74 Heading C3H A process for the production of the compound S7481/F-1 of Formula I the compound S7481/F-2 of Formula II or S748/F-1 combined with S748/F-2 comprises cultivating a suitable strain of the fungus species, Tolypocladium inflatum Gams or Cylindrocarpon lucidum Booth in contact with a nutrient medium and isolating the compound(s). Compound S7481/F-1 has the following characteristics: (a) when in amorphous form has a melting point of 137-140‹ C. (decomp.), (b) [α] D <SP>20</SP> = -236‹(CHCl 3 ; C=0À5), (c) J.R.(CH 2 Cl 2 ), see Fig. 2 (not shown), and (d) ultra violet spectrum (CH 3 OH; c=1À063 g./l., d=0À01 cm.) as in Fig. 1 (not shown) and compound S7481/ F-2 has the following charateristics: (a) when in amorphous form a melting point of 127- 130‹ C. (decomp.), (b) J.R.(CH 2 Cl 2 ) see Fig. 5 (not shown) and (c) ultra violet spectrum (CH 2 OH; c=1À062 g./l.; d=0À01 cm.) see Fig. 4 (not shown). Suitable fungus strains are Tolypocladium inflatum NRRL 8044 and Cylindrocarpon lucidum NRRL 5760. The compounds may be admixed with a suitable carrier or diluent to form a pharmaceutical composition.
[GB1491509A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1711173A CH589716A5 (en) | 1973-12-06 | 1973-12-06 | Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant |
| CH1404374A CH603790A5 (en) | 1974-10-21 | 1974-10-21 | Antibiotics S 7481-F-1 and 2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40549L true IE40549L (en) | 1975-06-06 |
| IE40549B1 IE40549B1 (en) | 1979-06-20 |
Family
ID=25713544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2502/74A IE40549B1 (en) | 1973-12-06 | 1974-12-04 | Metabolites s7481/f-1 and /f-2 |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5615235B2 (en) |
| AU (1) | AU500889B2 (en) |
| CA (1) | CA1030469A (en) |
| DD (1) | DD115695A5 (en) |
| DE (2) | DE2455859C2 (en) |
| DK (1) | DK136780B (en) |
| ES (1) | ES432559A1 (en) |
| FI (2) | FI52851C (en) |
| FR (1) | FR2253531B1 (en) |
| GB (1) | GB1491509A (en) |
| HK (1) | HK53880A (en) |
| IE (1) | IE40549B1 (en) |
| IL (1) | IL46180A (en) |
| MY (1) | MY8100203A (en) |
| NL (1) | NL179220C (en) |
| NO (1) | NO744292L (en) |
| NZ (1) | NZ176117A (en) |
| PH (1) | PH13773A (en) |
| SE (1) | SE423720B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (en) | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2907460A1 (en) * | 1978-03-07 | 1979-09-13 | Sandoz Ag | NEW RESORBABLE GALENIC COMPOSITIONS |
| SE448386B (en) * | 1978-10-18 | 1987-02-16 | Sandoz Ag | NEW CYCLOSPORIN DERIVATIVES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
| US4396542A (en) | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| ATE43335T1 (en) * | 1980-02-14 | 1989-06-15 | Sandoz Ag | PEPTIDES CONTAINING A (1S,2R,3R)-OR (1R,2S,3S)-1NITRILO-1-CARBONYL-3-METHYL-2-OXYHEPTAN OR HEPT-5-ENE MOiety USABLE IN TOTAL SYNTHESIS OF CYCLOSPORINS, AND PROCESS FOR THEIR MANUFACTURE. |
| DE3260468D1 (en) | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
| JPS59129920U (en) * | 1983-02-16 | 1984-08-31 | 日立造船株式会社 | Opening/closing device for bypass valve with gate |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| FI111730B (en) | 1990-11-02 | 2003-09-15 | Novartis Ag | A process for the preparation of a non-immunosuppressive cyclosporin |
| ATE158022T1 (en) * | 1991-01-25 | 1997-09-15 | Fujisawa Pharmaceutical Co | PROCESS FOR PRODUCING CYCLOSPORIN-A AND/OR C |
| KR100304324B1 (en) * | 1994-10-13 | 2001-11-22 | 김용규 | Method for manufacturing cyclosporine a |
| RU2158601C2 (en) | 1994-11-03 | 2000-11-10 | Новартис Аг | Novel medicinal forms of cyclosporine for oral administration having simple formulation and bioavailability, and method of preparation thereof |
| US6423233B1 (en) | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
| AU2004222306A1 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| EP1809656A4 (en) | 2004-09-29 | 2009-03-25 | Amr Technology Inc | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| EP2151450A1 (en) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Method for processing microbiologically produced cyclic oligopeptides |
-
1974
- 1974-11-26 DE DE2455859A patent/DE2455859C2/en not_active Expired
- 1974-11-26 DE DE2463138A patent/DE2463138C2/en not_active Expired
- 1974-11-27 FI FI743434A patent/FI52851C/en active
- 1974-11-27 DK DK617074AA patent/DK136780B/en unknown
- 1974-11-28 NO NO744292A patent/NO744292L/no unknown
- 1974-11-29 SE SE7415027A patent/SE423720B/en not_active IP Right Cessation
- 1974-12-02 GB GB52013/74A patent/GB1491509A/en not_active Expired
- 1974-12-02 NL NLAANVRAGE7415682,A patent/NL179220C/en not_active IP Right Cessation
- 1974-12-04 IE IE2502/74A patent/IE40549B1/en not_active IP Right Cessation
- 1974-12-04 ES ES432559A patent/ES432559A1/en not_active Expired
- 1974-12-04 NZ NZ176117A patent/NZ176117A/en unknown
- 1974-12-04 IL IL46180A patent/IL46180A/en unknown
- 1974-12-04 AU AU76081/74A patent/AU500889B2/en not_active Expired
- 1974-12-04 DD DD182775A patent/DD115695A5/xx unknown
- 1974-12-05 FR FR7439877A patent/FR2253531B1/fr not_active Expired
- 1974-12-05 CA CA215,287A patent/CA1030469A/en not_active Expired
- 1974-12-05 JP JP13893874A patent/JPS5615235B2/ja not_active Expired
-
1977
- 1977-04-15 FI FI771201A patent/FI54606C/en not_active IP Right Cessation
- 1977-04-22 PH PH19702A patent/PH13773A/en unknown
-
1980
- 1980-09-25 HK HK538/80A patent/HK53880A/en unknown
-
1981
- 1981-12-30 MY MY203/81A patent/MY8100203A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1030469A (en) | 1978-05-02 |
| JPS5615235B2 (en) | 1981-04-09 |
| MY8100203A (en) | 1981-12-31 |
| DE2463138C2 (en) | 1984-07-05 |
| SE423720B (en) | 1982-05-24 |
| DK136780B (en) | 1977-11-21 |
| AU500889B2 (en) | 1979-06-07 |
| FI343474A (en) | 1975-06-07 |
| FR2253531A1 (en) | 1975-07-04 |
| ES432559A1 (en) | 1977-03-01 |
| FI52851C (en) | 1977-12-12 |
| DK136780C (en) | 1978-05-01 |
| NZ176117A (en) | 1981-05-01 |
| FI52851B (en) | 1977-08-31 |
| SE7415027L (en) | 1975-06-09 |
| AU7608174A (en) | 1976-06-10 |
| DE2455859C2 (en) | 1983-12-15 |
| IE40549B1 (en) | 1979-06-20 |
| DE2455859A1 (en) | 1975-06-12 |
| DD115695A5 (en) | 1975-10-12 |
| NL7415682A (en) | 1975-06-10 |
| FR2253531B1 (en) | 1978-07-21 |
| FI771201A (en) | 1977-04-15 |
| JPS5089598A (en) | 1975-07-18 |
| NL179220B (en) | 1986-03-03 |
| IL46180A (en) | 1978-07-31 |
| GB1491509A (en) | 1977-11-09 |
| NO744292L (en) | 1975-06-30 |
| IL46180A0 (en) | 1975-03-13 |
| NL179220C (en) | 1986-08-01 |
| DK617074A (en) | 1975-07-28 |
| FI54606C (en) | 1979-01-10 |
| FI54606B (en) | 1978-09-29 |
| PH13773A (en) | 1980-09-23 |
| HK53880A (en) | 1980-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |