IE40549L - Metabolites s7481/f-1 and/f-2 - Google Patents

Metabolites s7481/f-1 and/f-2

Info

Publication number
IE40549L
IE40549L IE742502A IE250274A IE40549L IE 40549 L IE40549 L IE 40549L IE 742502 A IE742502 A IE 742502A IE 250274 A IE250274 A IE 250274A IE 40549 L IE40549 L IE 40549L
Authority
IE
Ireland
Prior art keywords
compound
see
decomp
nrrl
dec
Prior art date
Application number
IE742502A
Other versions
IE40549B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25713544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE40549(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH1711173A external-priority patent/CH589716A5/en
Priority claimed from CH1404374A external-priority patent/CH603790A5/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE40549L publication Critical patent/IE40549L/en
Publication of IE40549B1 publication Critical patent/IE40549B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/06—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

1491509 Antibiotics SANDOZ Ltd 2 Dec 1974 [6 Dec 1973 21 Oct 1974] 52013/74 Heading C3H A process for the production of the compound S7481/F-1 of Formula I the compound S7481/F-2 of Formula II or S748/F-1 combined with S748/F-2 comprises cultivating a suitable strain of the fungus species, Tolypocladium inflatum Gams or Cylindrocarpon lucidum Booth in contact with a nutrient medium and isolating the compound(s). Compound S7481/F-1 has the following characteristics: (a) when in amorphous form has a melting point of 137-140‹ C. (decomp.), (b) [α] D <SP>20</SP> = -236‹(CHCl 3 ; C=0À5), (c) J.R.(CH 2 Cl 2 ), see Fig. 2 (not shown), and (d) ultra violet spectrum (CH 3 OH; c=1À063 g./l., d=0À01 cm.) as in Fig. 1 (not shown) and compound S7481/ F-2 has the following charateristics: (a) when in amorphous form a melting point of 127- 130‹ C. (decomp.), (b) J.R.(CH 2 Cl 2 ) see Fig. 5 (not shown) and (c) ultra violet spectrum (CH 2 OH; c=1À062 g./l.; d=0À01 cm.) see Fig. 4 (not shown). Suitable fungus strains are Tolypocladium inflatum NRRL 8044 and Cylindrocarpon lucidum NRRL 5760. The compounds may be admixed with a suitable carrier or diluent to form a pharmaceutical composition. [GB1491509A]
IE2502/74A 1973-12-06 1974-12-04 Metabolites s7481/f-1 and /f-2 IE40549B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1711173A CH589716A5 (en) 1973-12-06 1973-12-06 Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant
CH1404374A CH603790A5 (en) 1974-10-21 1974-10-21 Antibiotics S 7481-F-1 and 2

Publications (2)

Publication Number Publication Date
IE40549L true IE40549L (en) 1975-06-06
IE40549B1 IE40549B1 (en) 1979-06-20

Family

ID=25713544

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2502/74A IE40549B1 (en) 1973-12-06 1974-12-04 Metabolites s7481/f-1 and /f-2

Country Status (19)

Country Link
JP (1) JPS5615235B2 (en)
AU (1) AU500889B2 (en)
CA (1) CA1030469A (en)
DD (1) DD115695A5 (en)
DE (2) DE2455859C2 (en)
DK (1) DK136780B (en)
ES (1) ES432559A1 (en)
FI (2) FI52851C (en)
FR (1) FR2253531B1 (en)
GB (1) GB1491509A (en)
HK (1) HK53880A (en)
IE (1) IE40549B1 (en)
IL (1) IL46180A (en)
MY (1) MY8100203A (en)
NL (1) NL179220C (en)
NO (1) NO744292L (en)
NZ (1) NZ176117A (en)
PH (1) PH13773A (en)
SE (1) SE423720B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2907460A1 (en) * 1978-03-07 1979-09-13 Sandoz Ag NEW RESORBABLE GALENIC COMPOSITIONS
SE448386B (en) * 1978-10-18 1987-02-16 Sandoz Ag NEW CYCLOSPORIN DERIVATIVES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3260468D1 (en) 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
JPS59129920U (en) * 1983-02-16 1984-08-31 日立造船株式会社 Opening/closing device for bypass valve with gate
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
SK278808B6 (en) 1990-11-02 1998-03-04 Novartis Ag Cyclosporines, their use at the preparation of drug for treating and preventing aids, preparation method thereof and fungal strains useable at this method
DE69222150T2 (en) * 1991-01-25 1998-01-15 Fujisawa Pharmaceutical Co PROCESS FOR THE PRODUCTION OF CYCLOSPORIN-A AND / OR C
KR100304324B1 (en) * 1994-10-13 2001-11-22 김용규 Method for manufacturing cyclosporine a
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US6423233B1 (en) 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
WO2004082629A2 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
EP1809656A4 (en) 2004-09-29 2009-03-25 Amr Technology Inc Cyclosporin alkyne analogues and their pharmaceutical uses
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2151450A1 (en) * 2008-07-29 2010-02-10 Sandoz AG Method for processing microbiologically produced cyclic oligopeptides

Also Published As

Publication number Publication date
DE2455859C2 (en) 1983-12-15
SE7415027L (en) 1975-06-07
FI343474A (en) 1975-06-07
NZ176117A (en) 1981-05-01
NL7415682A (en) 1975-06-10
JPS5615235B2 (en) 1981-04-09
FR2253531A1 (en) 1975-07-04
IL46180A0 (en) 1975-03-13
SE423720B (en) 1982-05-24
IE40549B1 (en) 1979-06-20
NL179220C (en) 1986-08-01
AU7608174A (en) 1976-06-10
DK136780C (en) 1978-05-01
FI771201A (en) 1977-04-15
IL46180A (en) 1978-07-31
DK617074A (en) 1975-07-28
DD115695A5 (en) 1975-10-12
FI54606B (en) 1978-09-29
PH13773A (en) 1980-09-23
GB1491509A (en) 1977-11-09
DE2463138C2 (en) 1984-07-05
FI52851C (en) 1977-12-12
AU500889B2 (en) 1979-06-07
CA1030469A (en) 1978-05-02
DE2455859A1 (en) 1975-06-12
FR2253531B1 (en) 1978-07-21
NO744292L (en) 1975-06-30
FI52851B (en) 1977-08-31
MY8100203A (en) 1981-12-31
DK136780B (en) 1977-11-21
NL179220B (en) 1986-03-03
HK53880A (en) 1980-10-03
FI54606C (en) 1979-01-10
JPS5089598A (en) 1975-07-18
ES432559A1 (en) 1977-03-01

Similar Documents

Publication Publication Date Title
IE40549B1 (en) Metabolites s7481/f-1 and /f-2
IE35416B1 (en) Compositions for the control of plant-pathogenic organisims
IE43592L (en) Heterocyclic compounds
GB1369934A (en) Process for the preparation of vincamine and vincamineanalogues
CA978118A (en) Enzymatic conversion process using flocculated microbial cells
AU522830B2 (en) New strains of yeast for breadmaking
IE42980L (en) Rifamycins
IE41898L (en) Decahydroisoquinolines
GB1314657A (en) Antibiotics
JPS5231001A (en) Novel antibiotics-complex
IE40837B1 (en) Vincadioline
ES439691A1 (en) Gardimycin and process for producing same
IE40205L (en) Ansamycin antibiotics
IE40051B1 (en) 7-(-(cyanomethyl-aryl)-acteamido)-cephalosporins
ES480904A1 (en) Antibiotic substance
AU5058379A (en) Socket with seal retainer
ES451318A1 (en) Fermentation of cephamycin C
AU1930376A (en) Gate valve seat ring retainer
JPS53104796A (en) Preparation of antibiotics
IE46064L (en) Antibiotic c-15003
IE39053L (en) Pharmaceutical compositions
ES8504935A1 (en) Antibiotic A51568 factors A and B.
JPS5272886A (en) Preparation of cephalosporin compound
EP0109750A3 (en) Nargenicin c1
JPS5247992A (en) Method of manufacturing new antibiotics, neothramycin a and b

Legal Events

Date Code Title Description
MK9A Patent expired