ES432559A1 - Metabolites s7481/f-1 and 1f-2 - Google Patents

Metabolites s7481/f-1 and 1f-2

Info

Publication number
ES432559A1
ES432559A1 ES432559A ES432559A ES432559A1 ES 432559 A1 ES432559 A1 ES 432559A1 ES 432559 A ES432559 A ES 432559A ES 432559 A ES432559 A ES 432559A ES 432559 A1 ES432559 A1 ES 432559A1
Authority
ES
Spain
Prior art keywords
indicated
accompanying drawings
spectrum
cdcl3
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432559A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25713544&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES432559(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH1711173A external-priority patent/CH589716A5/en
Priority claimed from CH1404374A external-priority patent/CH603790A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES432559A1 publication Critical patent/ES432559A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/06—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma

Abstract

Procedure for the production of antibiotics named, S 7481/F-1, of the formula indicated above, S 7481/F-2, or S 7481/F-1 and S748l/F-1, the antibiotic S 7481/F-1 having the following features: Amorphous, colorless powder; P.F. 137-140ºC (descoinp.); [α] 20D = -236º (CHCL3; c = 0.5); Ultraviolet spectrum [CH3OH; c = 1,063 g/l; d = 0.01 cm] as indicated in Figure 1 of the accompanying drawings; Infrared spectrum [CH2Cl2] as indicated in Figure 2 of the accompanying drawings; Proton nuclear magnetic resonance spectrum [90 megacycles per second; CDCl3] as indicated in Figure 3 of the accompanying drawings; Carbon 13 nuclear magnetic resonance spectrum [250 mg in 1.5 cc CDCl3; scope of the curve described 6000 megacycles per second] as indicated in the accompanying Table; High resolution mass spectrum [ion acceleration 4 kv; ion source temperature 290ºC; pressure 5.10-6 mm Hg] peak of the highest mass = m/e 1183,831 [+ -0.004] corresponding to C62H109N11011 that can be recognized as a water removal product of C26H111N11012; Elemental analysis C 61.8, H 9.4, N 13.0, 0 15.7% in accordance with the empirical formula C62H111N11012; and release of the amino acids alanine, α-aminobutyric acid, N-methyl-leucine, N-methyl-glycine and valine by reacting with 6-normal aqueous hydrochloric acid at reflux; and the antibiotic S 7481/F-2 having the following characteristics: Colorless, amorphous powder; P.F. 127-130ºC (decomp.); [α] 20D = -243º (CHCl3, c = 0.5); Ultraviolet spectrum [CH3OH; c = 1,062 g/l; d = 0.01 cm] as indicated in Figure 4 of the accompanying drawings; Infrared spectrum [CH2Cl2] as indicated in Figure 5 of the accompanying drawings; Proton nuclear magnetic resonance spectrum [90 megacycles per second; CDCl3] as indicated in Figure 6 of the accompanying drawings; High resolution mass spectrum [ion acceleration 4 kv; ion source temperature 290ºC; pressure 5.10-6 mm Hg] peak of the highest mass m/e 1169,815 (+ - 0.006) corresponding to C61H107N11011 the product of the water removal of C61H109N11012 and Elemental analysis found C 61, 7, H 9.1, N 13.1.0 16.5% in agreement with the empirical formula C61H109N11012; characterized by growing a strain producing S 7481/Fl, S 7481/F-2, or S 7481/F-1 and S 7481/F-2 of the fungal species Cylindrocarpon lucidum Booth or Trichoderma polysporum (Link ex Pers .) Kifai in contact with a nutrient medium and why S 7481/Fl, S 7481/F-2, or S 7481/F-1 and 8 7481/F-2 are isolated. (Machine-translation by Google Translate, not legally binding)
ES432559A 1973-12-06 1974-12-04 Metabolites s7481/f-1 and 1f-2 Expired ES432559A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1711173A CH589716A5 (en) 1973-12-06 1973-12-06 Antibiotics S 7481-F-1 and 2 - prepd. from new strains of Cylindrocarbon or Trichoderma esp. useful as immunosuppressant
CH1404374A CH603790A5 (en) 1974-10-21 1974-10-21 Antibiotics S 7481-F-1 and 2

Publications (1)

Publication Number Publication Date
ES432559A1 true ES432559A1 (en) 1977-03-01

Family

ID=25713544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES432559A Expired ES432559A1 (en) 1973-12-06 1974-12-04 Metabolites s7481/f-1 and 1f-2

Country Status (19)

Country Link
JP (1) JPS5615235B2 (en)
AU (1) AU500889B2 (en)
CA (1) CA1030469A (en)
DD (1) DD115695A5 (en)
DE (2) DE2463138C2 (en)
DK (1) DK136780B (en)
ES (1) ES432559A1 (en)
FI (2) FI52851C (en)
FR (1) FR2253531B1 (en)
GB (1) GB1491509A (en)
HK (1) HK53880A (en)
IE (1) IE40549B1 (en)
IL (1) IL46180A (en)
MY (1) MY8100203A (en)
NL (1) NL179220C (en)
NO (1) NO744292L (en)
NZ (1) NZ176117A (en)
PH (1) PH13773A (en)
SE (1) SE423720B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
SE445174B (en) * 1978-03-07 1986-06-09 Sandoz Ag PHARMACEUTICAL COMPOSITION CONTAINING A CYCLOSPORIN AND A HEALING SUBSTANCE
SE448386B (en) * 1978-10-18 1987-02-16 Sandoz Ag NEW CYCLOSPORIN DERIVATIVES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
DE3167014D1 (en) * 1980-02-14 1984-12-13 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
US4396542A (en) 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (en) 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
JPS59129920U (en) * 1983-02-16 1984-08-31 日立造船株式会社 Opening/closing device for bypass valve with gate
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
ATE148469T1 (en) 1990-11-02 1997-02-15 Sandoz Ag CYCLOSPORINS
CA2101777A1 (en) * 1991-01-25 1992-07-26 Toshio Goto Process for producing cyclosporin a and/or c
KR100304324B1 (en) * 1994-10-13 2001-11-22 김용규 Method for manufacturing cyclosporine a
RU2158601C2 (en) 1994-11-03 2000-11-10 Новартис Аг Novel medicinal forms of cyclosporine for oral administration having simple formulation and bioavailability, and method of preparation thereof
US6423233B1 (en) 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
AU2004222306A1 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
JP2008514701A (en) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド Cyclosporine alkyne analogs and their pharmaceutical use
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
EP2151450A1 (en) 2008-07-29 2010-02-10 Sandoz AG Method for processing microbiologically produced cyclic oligopeptides

Also Published As

Publication number Publication date
DE2455859A1 (en) 1975-06-12
FI343474A (en) 1975-06-07
HK53880A (en) 1980-10-03
FR2253531A1 (en) 1975-07-04
DD115695A5 (en) 1975-10-12
DK136780B (en) 1977-11-21
IL46180A (en) 1978-07-31
JPS5089598A (en) 1975-07-18
IE40549B1 (en) 1979-06-20
DK136780C (en) 1978-05-01
AU7608174A (en) 1976-06-10
NL7415682A (en) 1975-06-10
NO744292L (en) 1975-06-30
CA1030469A (en) 1978-05-02
FI52851B (en) 1977-08-31
FR2253531B1 (en) 1978-07-21
MY8100203A (en) 1981-12-31
FI54606B (en) 1978-09-29
FI54606C (en) 1979-01-10
JPS5615235B2 (en) 1981-04-09
GB1491509A (en) 1977-11-09
FI771201A (en) 1977-04-15
SE423720B (en) 1982-05-24
IL46180A0 (en) 1975-03-13
PH13773A (en) 1980-09-23
NZ176117A (en) 1981-05-01
SE7415027L (en) 1975-06-07
DE2455859C2 (en) 1983-12-15
AU500889B2 (en) 1979-06-07
DK617074A (en) 1975-07-28
NL179220B (en) 1986-03-03
FI52851C (en) 1977-12-12
DE2463138C2 (en) 1984-07-05
IE40549L (en) 1975-06-06
NL179220C (en) 1986-08-01

Similar Documents

Publication Publication Date Title
ES432559A1 (en) Metabolites s7481/f-1 and 1f-2
CA1025178A (en) Process for producing carbon black
AU497333B2 (en) Manifold for solar collector
AU7649474A (en) Novel composite fuel cell electrode
CA1021883A (en) Electron microscope comprising an energy analyser
ES450536A1 (en) Chroman-4-ones and process for preparing same
AU6763374A (en) Scanning electron microscope
AU471017B2 (en) Engine fuel vaporizer
JPS5231001A (en) Novel antibiotics-complex
ES439691A1 (en) Gardimycin and process for producing same
ES475593A1 (en) Novel biological substance from a fungus and the process for producing the same
ES8104319A1 (en) Process for producing 3-O-demethylfortimicins
CA1010844A (en) Process for the preparation of active carbon
JPS5228988A (en) Method for preparing microbial cells
JPS5270233A (en) Fuel pressure control apparatus
ES393771A1 (en) Process for the manufacture of zeaxanthin
CA1025130A (en) Electron microscope
JPS51115986A (en) Process for producing yeast cells
GB1420264A (en) Process for the preparation of protein
JPS55125797A (en) Diaphragm plate for acoustic unit
CA1025189A (en) Fabric with thin surface matrix and method for production thereof
CA1031173A (en) Fuel distribution manifold to an annular combustion chamber
JPS51151442A (en) Manufacturing process of inner ring material in complex gasket
JPS5294053A (en) Piezoelectric filter
ES449163A1 (en) Antibiotic complex