DE2448036A1 - Pyridylalkylester, verfahren zu ihrer herstellung und sie enthaltende arzneimittel - Google Patents
Pyridylalkylester, verfahren zu ihrer herstellung und sie enthaltende arzneimittelInfo
- Publication number
- DE2448036A1 DE2448036A1 DE19742448036 DE2448036A DE2448036A1 DE 2448036 A1 DE2448036 A1 DE 2448036A1 DE 19742448036 DE19742448036 DE 19742448036 DE 2448036 A DE2448036 A DE 2448036A DE 2448036 A1 DE2448036 A1 DE 2448036A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- addition salts
- ester
- acid addition
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 34
- 239000002253 acid Substances 0.000 claims description 15
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- -1 p-Chlorophenoxy Chemical group 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 5
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 239000002585 base Substances 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims description 2
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
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- 229910052799 carbon Inorganic materials 0.000 description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
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- 229910052739 hydrogen Inorganic materials 0.000 description 9
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- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
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- KUEUWHJGRZKESU-UHFFFAOYSA-N Niceritrol Chemical compound C=1C=CN=CC=1C(=O)OCC(COC(=O)C=1C=NC=CC=1)(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 KUEUWHJGRZKESU-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 239000004408 titanium dioxide Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7314402A SE377691B (enExample) | 1973-10-24 | 1973-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2448036A1 true DE2448036A1 (de) | 1975-05-15 |
Family
ID=20318905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742448036 Pending DE2448036A1 (de) | 1973-10-24 | 1974-10-09 | Pyridylalkylester, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5070372A (enExample) |
| AU (1) | AU7451674A (enExample) |
| BE (1) | BE821410A (enExample) |
| DE (1) | DE2448036A1 (enExample) |
| DK (1) | DK553974A (enExample) |
| FI (1) | FI309274A7 (enExample) |
| FR (1) | FR2248847A1 (enExample) |
| LU (1) | LU71169A1 (enExample) |
| NL (1) | NL7413950A (enExample) |
| NO (1) | NO743815L (enExample) |
| SE (1) | SE377691B (enExample) |
-
1973
- 1973-10-24 SE SE7314402A patent/SE377691B/xx unknown
-
1974
- 1974-10-09 DE DE19742448036 patent/DE2448036A1/de active Pending
- 1974-10-21 AU AU74516/74A patent/AU7451674A/en not_active Expired
- 1974-10-23 FI FI3092/74A patent/FI309274A7/fi unknown
- 1974-10-23 FR FR7435592A patent/FR2248847A1/fr not_active Withdrawn
- 1974-10-23 NO NO743815A patent/NO743815L/no unknown
- 1974-10-23 DK DK553974A patent/DK553974A/da unknown
- 1974-10-24 JP JP49123015A patent/JPS5070372A/ja active Pending
- 1974-10-24 NL NL7413950A patent/NL7413950A/xx unknown
- 1974-10-24 LU LU71169A patent/LU71169A1/xx unknown
- 1974-10-24 BE BE149820A patent/BE821410A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI309274A7 (enExample) | 1975-04-25 |
| AU7451674A (en) | 1976-04-29 |
| NO743815L (enExample) | 1975-05-20 |
| BE821410A (fr) | 1975-04-24 |
| FR2248847A1 (en) | 1975-05-23 |
| NL7413950A (nl) | 1975-04-28 |
| LU71169A1 (enExample) | 1975-06-24 |
| SE377691B (enExample) | 1975-07-21 |
| JPS5070372A (enExample) | 1975-06-11 |
| DK553974A (enExample) | 1975-06-16 |
| SE7314402L (enExample) | 1975-04-25 |
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