DE2447556A1 - Radiopharmazeutikum - Google Patents
RadiopharmazeutikumInfo
- Publication number
- DE2447556A1 DE2447556A1 DE19742447556 DE2447556A DE2447556A1 DE 2447556 A1 DE2447556 A1 DE 2447556A1 DE 19742447556 DE19742447556 DE 19742447556 DE 2447556 A DE2447556 A DE 2447556A DE 2447556 A1 DE2447556 A1 DE 2447556A1
- Authority
- DE
- Germany
- Prior art keywords
- radiopharmaceutical
- technetium
- tin
- mercaptoisobutyric acid
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012217 radiopharmaceutical Substances 0.000 title claims description 25
- 229940121896 radiopharmaceutical Drugs 0.000 title claims description 25
- 230000002799 radiopharmaceutical effect Effects 0.000 title claims description 25
- 229910052713 technetium Inorganic materials 0.000 claims description 18
- JTMBCYAUSCBSEY-UHFFFAOYSA-N 2-methyl-2-sulfanylpropanoic acid Chemical compound CC(C)(S)C(O)=O JTMBCYAUSCBSEY-UHFFFAOYSA-N 0.000 claims description 17
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 235000011150 stannous chloride Nutrition 0.000 claims description 9
- 238000003384 imaging method Methods 0.000 claims description 8
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims description 7
- 239000003638 chemical reducing agent Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- -1 tin (II) ions Chemical class 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 claims 1
- 239000001119 stannous chloride Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 description 16
- 210000000013 bile duct Anatomy 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 239000012216 imaging agent Substances 0.000 description 5
- 238000010253 intravenous injection Methods 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940056501 technetium 99m Drugs 0.000 description 2
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 1
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 229930187593 rose bengal Natural products 0.000 description 1
- 229940081623 rose bengal Drugs 0.000 description 1
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electromechanical Clocks (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US407409A US3928552A (en) | 1973-10-18 | 1973-10-18 | Hepato-biliary radiopharmaceutical comprising 2-mercaptoisobutyric acid chelating reduced technetium-99m |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2447556A1 true DE2447556A1 (de) | 1975-04-30 |
Family
ID=23611956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742447556 Withdrawn DE2447556A1 (de) | 1973-10-18 | 1974-10-02 | Radiopharmazeutikum |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3928552A (enrdf_load_stackoverflow) |
| JP (1) | JPS585887B2 (enrdf_load_stackoverflow) |
| CH (1) | CH609564A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2447556A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2248055B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1441506A (enrdf_load_stackoverflow) |
| IT (1) | IT1050251B (enrdf_load_stackoverflow) |
| NL (1) | NL7413506A (enrdf_load_stackoverflow) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1029721A (en) * | 1973-04-23 | 1978-04-18 | Theodore F. Bolles | Technetium-labeled complexes, production and use thereof |
| US4233285A (en) * | 1973-05-14 | 1980-11-11 | Medi-Physics, Inc. | Mercaptocarboxylic acid radiopharmaceuticals |
| US4091088A (en) * | 1975-02-19 | 1978-05-23 | Australian Atomic Energy Commission | Phenolic amino-carboxylic acid complexes for forming radiopharmaceuticals |
| US4298591A (en) * | 1979-04-03 | 1981-11-03 | The United States Of America As Represented By The United States Department Of Energy | Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor |
| US4489054A (en) * | 1980-04-18 | 1984-12-18 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| US4670545A (en) * | 1984-05-11 | 1987-06-02 | University Patents, Inc. | Chelating agents for technetium-99M |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| KR100445971B1 (ko) * | 2002-04-15 | 2004-08-25 | 한국원자력연구소 | 수소화붕소 교환수지를 이용한 테크네튬 또는 레늄의표지방법 |
| EP2642354B1 (fr) * | 2012-03-23 | 2015-10-21 | Omega SA | Mécanisme d'affichage et de correction d'état de deux grandeurs temporelles différentes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824399A (en) * | 1971-01-27 | 1974-07-16 | Saab Scania Ab | Method of in vivo examination of organ functions |
| US3749913A (en) * | 1971-06-24 | 1973-07-31 | Administrator Of The Veterans | Renal scanning composition and method using technetium 99m |
| US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
-
1973
- 1973-10-18 US US407409A patent/US3928552A/en not_active Expired - Lifetime
-
1974
- 1974-09-25 GB GB4171674A patent/GB1441506A/en not_active Expired
- 1974-10-02 DE DE19742447556 patent/DE2447556A1/de not_active Withdrawn
- 1974-10-14 NL NL7413506A patent/NL7413506A/xx not_active Application Discontinuation
- 1974-10-16 FR FR7434814A patent/FR2248055B1/fr not_active Expired
- 1974-10-17 JP JP49119877A patent/JPS585887B2/ja not_active Expired
- 1974-10-17 IT IT53586/74A patent/IT1050251B/it active
- 1974-10-17 CH CH1393274A patent/CH609564A5/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7413506A (nl) | 1975-04-22 |
| US3928552A (en) | 1975-12-23 |
| GB1441506A (en) | 1976-07-07 |
| CH609564A5 (enrdf_load_stackoverflow) | 1979-03-15 |
| IT1050251B (it) | 1981-03-10 |
| FR2248055B1 (enrdf_load_stackoverflow) | 1978-07-21 |
| JPS50111222A (enrdf_load_stackoverflow) | 1975-09-01 |
| JPS585887B2 (ja) | 1983-02-02 |
| FR2248055A1 (enrdf_load_stackoverflow) | 1975-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69320481T2 (de) | Tetraazamakrocyclische metallkomplexe | |
| EP0271806B2 (de) | Verfahren zur Herstellung einer mit Technetium-99m-markierten organspezifischen Substanz | |
| DE2447556A1 (de) | Radiopharmazeutikum | |
| DE2538388A1 (de) | Verfahren zur herstellung eines stabilen, nicht-radioaktiven traegermaterials und seine verwendung zur herstellung von tc-99m-markierten diagnosemitteln | |
| DE3237573A1 (de) | Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung | |
| DE2235681A1 (de) | Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen | |
| DE2600311A1 (de) | Markierte phospholipoidsphaeren fuer die organdarstellung | |
| DE2947500C2 (de) | Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber | |
| DE2124752A1 (de) | Verfahren zur Herstellung eines diagnostischen Präparats auf Basis von Makroaggregaten von mit 99mTc markiertem Serumeiweiß | |
| DE2423167C2 (de) | Radiodiagnostikum, Verfahren zu dessen Herstellung und dessen Verwendung als intravenöse Injektionslösung | |
| DE2207309C3 (de) | Isotopengenerator | |
| DE69002627T2 (de) | 99 m Tc (III) herzmuskelbildende Mittel, wirksam beim Menschen. | |
| DE2534985A1 (de) | Verfahren zum markieren mit 99 m technetium | |
| DE3331159A1 (de) | N-(4-aminobenzoyl)-aminodicarbonsaeuren zur stabilisierung von technetium-99m-praeparaten, stabilisierte injektionspraeparate und verfahren zu ihrer herstellung | |
| EP0003041B1 (de) | Technetium-99m-markiertes Diagnostikum zur Darstellung des retikuloendothelialen Systems (RES) und Verfahren zu seiner Herstellung | |
| EP0019790B1 (de) | Technetium-99m-markierte Acetanilidoiminodiacetate zur Leberfunktionsdiagnostik und Verfahren zu ihrer Herstellung | |
| DE2855334A1 (de) | Technetium-99m-markiertes (2,4,5-trimethylacetanilido)-iminodiacetat zur leberfunktionsdiagnostik und verfahren zur herstellung | |
| DE1932231A1 (de) | Diagnostisches und therapeutisches Praeparat auf der Basis eines chelatgebundenen Radio-Nuclids | |
| DE2124751A1 (de) | Verfahren zur Herstellung eines diagnostischen Präparats auf Basis eines mit 99mTc markierten Eisenkomplexes | |
| DE2551480B2 (de) | Technetium-99m-markiertes Nierendiagnostikum und Verfahren zu seiner Herstellung | |
| DE2419310B2 (de) | Verwendung von Tc-99m-Komplexen | |
| DE3524004A1 (de) | Generator fuer kurzlebige radionuclide | |
| DE69525647T2 (de) | Inklusionskomplexe von radiohalogenierten fettsäuren in einer zyklodextrine | |
| DE1234931B (de) | Roentgenkontrastmittel | |
| DE2536008C3 (de) | Verfahren zur Herstellung von zur Bindung von Technetium geeigneten zinnhaltigen Humanserumalbumin-Partikeln |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee | ||
| 8141 | Disposal/no request for examination |