DE2416903A1 - Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren - Google Patents

Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren

Info

Publication number
DE2416903A1
DE2416903A1 DE19742416903 DE2416903A DE2416903A1 DE 2416903 A1 DE2416903 A1 DE 2416903A1 DE 19742416903 DE19742416903 DE 19742416903 DE 2416903 A DE2416903 A DE 2416903A DE 2416903 A1 DE2416903 A1 DE 2416903A1
Authority
DE
Germany
Prior art keywords
tablets
melt
phenacetin
granules
sprayed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19742416903
Other languages
German (de)
English (en)
Inventor
Ernst Dr Boecker
Wolfgang Dr Kracht
Roland Dr Rupp
Erhard Dr Schellmann
Viktor Dr Trescher
Martin Dipl Ing Ullrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19742416903 priority Critical patent/DE2416903A1/de
Priority to FR7510587A priority patent/FR2274280A1/fr
Priority to IE75575A priority patent/IE40907B1/xx
Priority to BE155086A priority patent/BE827560A/xx
Priority to NL7504054A priority patent/NL7504054A/xx
Priority to DK146175A priority patent/DK136398C/da
Priority to GB1392175A priority patent/GB1480188A/en
Priority to LU72206A priority patent/LU72206A1/xx
Publication of DE2416903A1 publication Critical patent/DE2416903A1/de
Priority to US05/720,650 priority patent/US4086346A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19742416903 1974-04-06 1974-04-06 Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren Pending DE2416903A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE19742416903 DE2416903A1 (de) 1974-04-06 1974-04-06 Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren
FR7510587A FR2274280A1 (fr) 1974-04-06 1975-04-04 Procede de pastillage direct de la phenacetine et produits obtenus
IE75575A IE40907B1 (en) 1974-04-06 1975-04-04 Use of melt-sprayed spherical phenacetin granules for the production of tablets
BE155086A BE827560A (fr) 1974-04-06 1975-04-04 Procede de pastillage direct de la phenacetine et produits obtenus
NL7504054A NL7504054A (nl) 1974-04-06 1975-04-04 Werkwijze voor het vervaardigen van gevormde farmaceutische preparaten met een analgetische en/of antipyretische werking alsmede aldus verkregen gevormde farmaceutische preparaten.
DK146175A DK136398C (da) 1974-04-06 1975-04-04 Fremgangsmaade til fremstilling af et analgetisk-antipyretisk praeparat
GB1392175A GB1480188A (en) 1974-04-06 1975-04-04 Use of melt-sprayed spherical phenacetin granules for the production of tablets
LU72206A LU72206A1 (US06826419-20041130-M00005.png) 1974-04-06 1975-04-04
US05/720,650 US4086346A (en) 1974-04-06 1976-09-07 Preparation of melt-sprayed spherical phenacetin granules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742416903 DE2416903A1 (de) 1974-04-06 1974-04-06 Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren

Publications (1)

Publication Number Publication Date
DE2416903A1 true DE2416903A1 (de) 1975-10-09

Family

ID=5912381

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742416903 Pending DE2416903A1 (de) 1974-04-06 1974-04-06 Verwendung von schmelzverspruehtem kugelfoermigem phenacetingranulat zur herstellung von tabletten im direkttablettierverfahren

Country Status (8)

Country Link
BE (1) BE827560A (US06826419-20041130-M00005.png)
DE (1) DE2416903A1 (US06826419-20041130-M00005.png)
DK (1) DK136398C (US06826419-20041130-M00005.png)
FR (1) FR2274280A1 (US06826419-20041130-M00005.png)
GB (1) GB1480188A (US06826419-20041130-M00005.png)
IE (1) IE40907B1 (US06826419-20041130-M00005.png)
LU (1) LU72206A1 (US06826419-20041130-M00005.png)
NL (1) NL7504054A (US06826419-20041130-M00005.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586561A1 (fr) * 1985-09-05 1987-03-06 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus
WO1987001936A1 (en) * 1985-09-25 1987-04-09 Gerhard Gergely Desintegration tablet and process for its manufacture
US4710519A (en) * 1985-09-30 1987-12-01 Basf Corporation Process for preparing spray dried acetaminophen powder and the powder prepared thereby
FR2620332A1 (fr) * 1987-09-11 1989-03-17 Squibb & Sons Inc Composition pharmaceutique a forte teneur en medicament, et procede pour la preparer

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034035A (en) * 1975-07-14 1977-07-05 Merck & Co., Inc. Method of preparing multi-toned tablets
US4517179A (en) * 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
HU206824B (en) * 1990-08-24 1993-01-28 Biogal Gyogyszergyar Process for the production of a table crystallizing in the monoclinic system, which contains light-, heat-, and moisture- sensitive active agents
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
JP3118255B2 (ja) * 1991-01-30 2000-12-18 ザ ウエルカム ファウンデーション リミテッド 水分散性錠剤
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586561A1 (fr) * 1985-09-05 1987-03-06 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus
EP0219377A1 (fr) * 1985-09-05 1987-04-22 Rhone-Poulenc Sante Procédé de préparation d'agglomerats sphériques de paracétamol et produits obtenus
WO1987001936A1 (en) * 1985-09-25 1987-04-09 Gerhard Gergely Desintegration tablet and process for its manufacture
US4832956A (en) * 1985-09-25 1989-05-23 Gerhard Gergely Disintegrating tablet and process for its preparation
US4710519A (en) * 1985-09-30 1987-12-01 Basf Corporation Process for preparing spray dried acetaminophen powder and the powder prepared thereby
FR2620332A1 (fr) * 1987-09-11 1989-03-17 Squibb & Sons Inc Composition pharmaceutique a forte teneur en medicament, et procede pour la preparer

Also Published As

Publication number Publication date
BE827560A (fr) 1975-10-06
GB1480188A (en) 1977-07-20
FR2274280A1 (fr) 1976-01-09
DK136398B (da) 1977-10-10
DK136398C (da) 1978-04-10
DK146175A (US06826419-20041130-M00005.png) 1975-10-07
IE40907B1 (en) 1979-09-12
IE40907L (en) 1975-10-06
LU72206A1 (US06826419-20041130-M00005.png) 1976-03-02
FR2274280B1 (US06826419-20041130-M00005.png) 1978-11-10
NL7504054A (nl) 1975-10-08

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