DE2409273A1 - Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen - Google Patents
Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionenInfo
- Publication number
- DE2409273A1 DE2409273A1 DE2409273A DE2409273A DE2409273A1 DE 2409273 A1 DE2409273 A1 DE 2409273A1 DE 2409273 A DE2409273 A DE 2409273A DE 2409273 A DE2409273 A DE 2409273A DE 2409273 A1 DE2409273 A1 DE 2409273A1
- Authority
- DE
- Germany
- Prior art keywords
- measuring
- light
- laser
- antigen
- photodetector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 17
- 238000006243 chemical reaction Methods 0.000 title claims description 13
- 239000000427 antigen Substances 0.000 claims description 17
- 102000036639 antigens Human genes 0.000 claims description 17
- 108091007433 antigens Proteins 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 7
- 102000009027 Albumins Human genes 0.000 description 6
- 108010088751 Albumins Proteins 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 230000000951 immunodiffusion Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Spectrometry And Color Measurement (AREA)
- Length Measuring Devices By Optical Means (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2409273A DE2409273A1 (de) | 1974-02-27 | 1974-02-27 | Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen |
| IL46675A IL46675A (en) | 1974-02-27 | 1975-02-20 | Process and device for measuring antigen-antibody reactions |
| ES434970A ES434970A1 (es) | 1974-02-27 | 1975-02-21 | Procedimiento y dispositivo para la medicion de reacciones de antigenos-anticuerpos. |
| NL7502108A NL7502108A (nl) | 1974-02-27 | 1975-02-21 | Werkwijze voor het meten van antigeen-anti- lichaam-reacties en inrichting voor het toe- passen van deze werkwijze. |
| AT145475A AT357269B (de) | 1974-02-27 | 1975-02-25 | Verfahren und vorrichtung zum verfolgen von antigen-antikoerper-reaktionen |
| IT20662/75A IT1037160B (it) | 1974-02-27 | 1975-02-25 | Apparecchio per la misura di reazioni antigene anticorpo |
| NO750639A NO750639L (en, 2012) | 1974-02-27 | 1975-02-25 | |
| LU71918A LU71918A1 (en, 2012) | 1974-02-27 | 1975-02-25 | |
| US05/552,883 US3990851A (en) | 1974-02-27 | 1975-02-25 | Process and device for measuring antigen-antibody reactions |
| AU78529/75A AU497203B2 (en) | 1974-02-27 | 1975-02-25 | Neohelometer |
| IE410/75A IE40697B1 (en) | 1974-02-27 | 1975-02-26 | Process and device for measuring particulate matter in suspension |
| DK76275*#A DK76275A (en, 2012) | 1974-02-27 | 1975-02-26 | |
| CH241275A CH585406A5 (en, 2012) | 1974-02-27 | 1975-02-26 | |
| CA221,054A CA1028168A (en) | 1974-02-27 | 1975-02-26 | Process and device for measuring antigen-antibody reactions |
| GB8266/75A GB1506593A (en) | 1974-02-27 | 1975-02-27 | Process and device for measuring particulate matter in suspension |
| SE7502211A SE402027B (sv) | 1974-02-27 | 1975-02-27 | Anordning for metning av antigen-antikropp-reaktioner |
| FR7506142A FR2262307B1 (en, 2012) | 1974-02-27 | 1975-02-27 | |
| JP50023489A JPS50121422A (en, 2012) | 1974-02-27 | 1975-02-27 | |
| BE153835A BE826085A (fr) | 1974-02-27 | 1975-02-27 | Procede et dispositif pour mesurer les reactions antigene-anticorps |
| JP58164272A JPS5990053A (ja) | 1974-02-27 | 1983-09-08 | 抗原−抗体反応 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2409273A DE2409273A1 (de) | 1974-02-27 | 1974-02-27 | Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2409273A1 true DE2409273A1 (de) | 1975-09-04 |
Family
ID=5908545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2409273A Pending DE2409273A1 (de) | 1974-02-27 | 1974-02-27 | Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3990851A (en, 2012) |
| JP (2) | JPS50121422A (en, 2012) |
| AT (1) | AT357269B (en, 2012) |
| AU (1) | AU497203B2 (en, 2012) |
| BE (1) | BE826085A (en, 2012) |
| CA (1) | CA1028168A (en, 2012) |
| CH (1) | CH585406A5 (en, 2012) |
| DE (1) | DE2409273A1 (en, 2012) |
| DK (1) | DK76275A (en, 2012) |
| ES (1) | ES434970A1 (en, 2012) |
| FR (1) | FR2262307B1 (en, 2012) |
| GB (1) | GB1506593A (en, 2012) |
| IE (1) | IE40697B1 (en, 2012) |
| IL (1) | IL46675A (en, 2012) |
| IT (1) | IT1037160B (en, 2012) |
| LU (1) | LU71918A1 (en, 2012) |
| NL (1) | NL7502108A (en, 2012) |
| NO (1) | NO750639L (en, 2012) |
| SE (1) | SE402027B (en, 2012) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053229A (en) * | 1976-01-13 | 1977-10-11 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | 2°/90° Laboratory scattering photometer |
| EP0021236A1 (en) * | 1979-06-13 | 1981-01-07 | Mitsubishi Kasei Corporation | Method for optically assaying liquid samples |
| EP0118823A3 (de) * | 1983-03-04 | 1985-11-13 | Steiner, R., Prof. Dr. | Verfahren und Vorrichtung zur Bestimmung von Trübungen in Flüssigkeiten |
| DE3608552A1 (de) * | 1986-03-14 | 1987-09-17 | Bayer Ag | Nephelometer |
| US6791676B1 (en) | 1999-10-08 | 2004-09-14 | Dade Behring Marburg Gmbh | Spectrophotometric and nephelometric detection unit |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080264A (en) * | 1976-03-01 | 1978-03-21 | Massachusetts Institute Of Technology | Immunoassay by light scattering spectroscopy |
| CH592933A5 (en, 2012) * | 1976-04-05 | 1977-11-15 | Cerberus Ag | |
| CA1081497A (en) * | 1976-06-02 | 1980-07-15 | Robert J. Anderson | System for rate immunonephelometric analysis |
| US4157871A (en) * | 1976-06-02 | 1979-06-12 | Beckman Instruments, Inc. | System for rate immunonephelometric analysis |
| US4268171A (en) * | 1977-07-18 | 1981-05-19 | Beckman Instruments, Inc. | Method determining concentration in rate nephelometric immunochemical analysis |
| US4197088A (en) * | 1977-09-23 | 1980-04-08 | Akro-Medic Engineering, Inc. | Method for qualitative and quantitative determination of immunological reactions |
| US4411518A (en) * | 1977-09-23 | 1983-10-25 | Gamma Biologicals, Inc. | Apparatus for use in qualitative determination of immunological reactions |
| US4174952A (en) * | 1978-01-23 | 1979-11-20 | Massachusetts Institute Of Technology | Immunoassay by light scattering intensity anisotropy measurements |
| US4204837A (en) * | 1978-03-14 | 1980-05-27 | Beckman Instruments, Inc. | Method of rate immunonephelometric analysis |
| US4222744A (en) * | 1978-09-27 | 1980-09-16 | Becton Dickinson & Company | Assay for ligands |
| US4488812A (en) * | 1979-05-22 | 1984-12-18 | American Home Products Corporation | Photometric apparatus |
| US4291983A (en) * | 1979-05-22 | 1981-09-29 | American Home Products Corporation | Photometric apparatus and method |
| US4284412A (en) * | 1979-07-13 | 1981-08-18 | Ortho Diagnostics, Inc. | Method and apparatus for automated identification and enumeration of specified blood cell subclasses |
| US5238810A (en) * | 1986-09-22 | 1993-08-24 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus thereof |
| US5252493A (en) * | 1986-09-22 | 1993-10-12 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus therefor |
| GB2203542A (en) * | 1987-04-14 | 1988-10-19 | Secr Defence | Measuring particle size distribution |
| US4988630A (en) * | 1987-04-27 | 1991-01-29 | Hoffmann-La Roche Inc. | Multiple beam laser instrument for measuring agglutination reactions |
| JPH07104304B2 (ja) * | 1987-06-11 | 1995-11-13 | 大阪酸素工業株式会社 | ガス中の微量水分量測定装置 |
| US5100805A (en) * | 1989-01-26 | 1992-03-31 | Seradyn, Inc. | Quantitative immunoassay system and method for agglutination assays |
| GB9313052D0 (en) * | 1993-06-24 | 1993-08-11 | Mini Agriculture & Fisheries | Detection of microbial growth |
| FR2719902B1 (fr) * | 1994-05-11 | 1996-07-05 | Pasteur Sanofi Diagnostics | Système d'analyse optique d'un échantillon de mélange réactionnel. |
| DE19640121B4 (de) | 1996-09-28 | 2007-04-26 | Dade Behring Marburg Gmbh | Verfahren zur Bestimmung einer sich zeitabhängig ändernden Meßgröße |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1802269C3 (de) * | 1968-10-10 | 1979-09-27 | Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe | Verfahren zum Messen der Konzentration und/oder Größe von Schwebstoffteilchen |
| US3713743A (en) * | 1970-11-25 | 1973-01-30 | Agricultural Control Syst | Forward scatter optical turbidimeter apparatus |
| US3786261A (en) * | 1971-10-12 | 1974-01-15 | Coulter Electronics | Optical scanning device |
| FR2195907A5 (en, 2012) * | 1972-08-10 | 1974-03-08 | Meric Jean Paul | |
| US3835315A (en) * | 1972-12-06 | 1974-09-10 | Us Commerce | System for determining parameters of a particle by radiant energy scattering techniques |
| US3843268A (en) * | 1973-07-05 | 1974-10-22 | Beckman Instruments Inc | Sample container for laser light scattering photometers |
-
1974
- 1974-02-27 DE DE2409273A patent/DE2409273A1/de active Pending
-
1975
- 1975-02-20 IL IL46675A patent/IL46675A/en unknown
- 1975-02-21 ES ES434970A patent/ES434970A1/es not_active Expired
- 1975-02-21 NL NL7502108A patent/NL7502108A/xx active Search and Examination
- 1975-02-25 NO NO750639A patent/NO750639L/no unknown
- 1975-02-25 IT IT20662/75A patent/IT1037160B/it active
- 1975-02-25 AT AT145475A patent/AT357269B/de not_active IP Right Cessation
- 1975-02-25 AU AU78529/75A patent/AU497203B2/en not_active Expired
- 1975-02-25 LU LU71918A patent/LU71918A1/xx unknown
- 1975-02-25 US US05/552,883 patent/US3990851A/en not_active Expired - Lifetime
- 1975-02-26 IE IE410/75A patent/IE40697B1/xx unknown
- 1975-02-26 CH CH241275A patent/CH585406A5/xx not_active IP Right Cessation
- 1975-02-26 DK DK76275*#A patent/DK76275A/da not_active Application Discontinuation
- 1975-02-26 CA CA221,054A patent/CA1028168A/en not_active Expired
- 1975-02-27 GB GB8266/75A patent/GB1506593A/en not_active Expired
- 1975-02-27 SE SE7502211A patent/SE402027B/xx not_active IP Right Cessation
- 1975-02-27 FR FR7506142A patent/FR2262307B1/fr not_active Expired
- 1975-02-27 BE BE153835A patent/BE826085A/xx not_active IP Right Cessation
- 1975-02-27 JP JP50023489A patent/JPS50121422A/ja active Pending
-
1983
- 1983-09-08 JP JP58164272A patent/JPS5990053A/ja active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053229A (en) * | 1976-01-13 | 1977-10-11 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | 2°/90° Laboratory scattering photometer |
| EP0021236A1 (en) * | 1979-06-13 | 1981-01-07 | Mitsubishi Kasei Corporation | Method for optically assaying liquid samples |
| EP0118823A3 (de) * | 1983-03-04 | 1985-11-13 | Steiner, R., Prof. Dr. | Verfahren und Vorrichtung zur Bestimmung von Trübungen in Flüssigkeiten |
| DE3608552A1 (de) * | 1986-03-14 | 1987-09-17 | Bayer Ag | Nephelometer |
| US6791676B1 (en) | 1999-10-08 | 2004-09-14 | Dade Behring Marburg Gmbh | Spectrophotometric and nephelometric detection unit |
Also Published As
| Publication number | Publication date |
|---|---|
| US3990851A (en) | 1976-11-09 |
| IL46675A (en) | 1976-12-31 |
| LU71918A1 (en, 2012) | 1977-01-06 |
| GB1506593A (en) | 1978-04-05 |
| JPS50121422A (en, 2012) | 1975-09-23 |
| SE7502211L (en, 2012) | 1975-08-28 |
| IL46675A0 (en) | 1975-04-25 |
| AT357269B (de) | 1980-06-25 |
| CA1028168A (en) | 1978-03-21 |
| IE40697L (en) | 1975-08-27 |
| NO750639L (en, 2012) | 1975-08-28 |
| BE826085A (fr) | 1975-08-27 |
| NL7502108A (nl) | 1975-08-29 |
| DK76275A (en, 2012) | 1975-10-27 |
| ATA145475A (de) | 1979-11-15 |
| IE40697B1 (en) | 1979-08-01 |
| AU497203B2 (en) | 1978-12-07 |
| IT1037160B (it) | 1979-11-10 |
| CH585406A5 (en, 2012) | 1977-02-28 |
| JPS5990053A (ja) | 1984-05-24 |
| SE402027B (sv) | 1978-06-12 |
| ES434970A1 (es) | 1976-12-16 |
| AU7852975A (en) | 1976-08-26 |
| FR2262307B1 (en, 2012) | 1980-11-14 |
| FR2262307A1 (en, 2012) | 1975-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHW | Rejection |