DE2350608A1 - Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen - Google Patents

Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen

Info

Publication number
DE2350608A1
DE2350608A1 DE19732350608 DE2350608A DE2350608A1 DE 2350608 A1 DE2350608 A1 DE 2350608A1 DE 19732350608 DE19732350608 DE 19732350608 DE 2350608 A DE2350608 A DE 2350608A DE 2350608 A1 DE2350608 A1 DE 2350608A1
Authority
DE
Germany
Prior art keywords
hydrogen
cyclic
phosphoric acid
acid ester
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19732350608
Other languages
German (de)
English (en)
Inventor
Gordon H Jones
John G Moffatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of DE2350608A1 publication Critical patent/DE2350608A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19732350608 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen Pending DE2350608A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29588972A 1972-10-10 1972-10-10
US378220A US3872098A (en) 1972-10-10 1973-07-11 1,n{hu 6{b ethenoadenosine cyclophosphate compounds

Publications (1)

Publication Number Publication Date
DE2350608A1 true DE2350608A1 (de) 1974-04-25

Family

ID=26969389

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19732350608 Pending DE2350608A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von l,n hoch 6-aethenoadenosinen
DE2365720*A Pending DE2365720A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2365720*A Pending DE2365720A1 (de) 1972-10-10 1973-10-09 Cyclische phosphorsaeureester von 1,n hoch 6-aethenoadenosinen

Country Status (5)

Country Link
US (1) US3872098A (enExample)
JP (1) JPS4986398A (enExample)
DE (2) DE2350608A1 (enExample)
FR (1) FR2201897A1 (enExample)
GB (1) GB1438574A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086176A (en) * 1989-03-29 1992-02-04 Merrell Dow Pharmaceuticals Inc. Tricyclic fused adenine derivatives

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960840A (en) * 1972-12-29 1976-06-01 University Of Illinois Foundaton Fluorescent derivatives of adenine-containing compounds
US4058659A (en) * 1974-05-31 1977-11-15 Icn Pharmaceuticals, Inc. 6,8-Disubstituted purine derivatives of 9-β-D-ribofuranosyl 3',5'-cyclic phosphate
US4048307A (en) * 1974-12-26 1977-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Cyclic adenosine monophosphate 8-substituted derivatives
JPS5312892A (en) * 1976-07-23 1978-02-04 Kikkoman Corp Novel 1,n6-etheno-2-substituted-adenosine-3,5-cyclic phosphoric acid and its preparation
JPS5841895A (ja) * 1981-09-04 1983-03-11 Yamasa Shoyu Co Ltd ７−オキソピリド〔２，１−ｉ〕プリンリボヌクレオシド誘導体およびその合成法
JPS60239496A (ja) * 1984-05-11 1985-11-28 Kikkoman Corp Ｎ↑６−置換−アデノシン−３′，５′−環状リン酸及びその塩の製法
US20040186282A1 (en) * 2003-03-20 2004-09-23 Chait Edward M. Synthesis and method of purification of cyclic nucleotide derivatives
KR20110128947A (ko) * 2009-03-20 2011-11-30 앨리오스 바이오파마 인크. 치환된 뉴클레오시드 및 뉴클레오티드 유사체
SG188497A1 (en) 2010-09-22 2013-05-31 Alios Biopharma Inc Substituted nucleotide analogs
HK1203075A1 (en) 2011-12-22 2015-10-16 艾丽奥斯生物制药有限公司 Substituted phosphorothioate nucleotide analogs
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
HK1203356A1 (en) 2012-03-22 2015-10-30 艾丽奥斯生物制药有限公司 Pharmaceutical combinations comprising a thionucleotide analog

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE738543A (enExample) * 1968-09-10 1970-03-09
US3558595A (en) * 1969-02-28 1971-01-26 Syntex Corp 2'-cyclic esters and 5'-cyclic esters of 3'-deoxy - 3' - dihydroxyphosphinylmethyl - beta - d - ribofuranosylnucleoside derivatives and intermediates therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086176A (en) * 1989-03-29 1992-02-04 Merrell Dow Pharmaceuticals Inc. Tricyclic fused adenine derivatives

Also Published As

Publication number Publication date
US3872098A (en) 1975-03-18
FR2201897A1 (enExample) 1974-05-03
JPS4986398A (enExample) 1974-08-19
DE2365720A1 (de) 1976-01-15
GB1438574A (en) 1976-06-09

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