DE2337068A1 - 1-benzylindenylsaeuren - Google Patents

1-benzylindenylsaeuren

Info

Publication number
DE2337068A1
DE2337068A1 DE19732337068 DE2337068A DE2337068A1 DE 2337068 A1 DE2337068 A1 DE 2337068A1 DE 19732337068 DE19732337068 DE 19732337068 DE 2337068 A DE2337068 A DE 2337068A DE 2337068 A1 DE2337068 A1 DE 2337068A1
Authority
DE
Germany
Prior art keywords
hydrogen
methyl
hydroxy
alkoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19732337068
Other languages
German (de)
English (en)
Inventor
Witzel Bruce Edward
Howard Jones
Tsung-Ying Shen
Bruce Edward Witzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2337068A1 publication Critical patent/DE2337068A1/de
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/38Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19732337068 1972-07-21 1973-07-20 1-benzylindenylsaeuren Ceased DE2337068A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00274038A US3851063A (en) 1972-07-21 1972-07-21 Treatment of pain,fever or inflammation

Publications (1)

Publication Number Publication Date
DE2337068A1 true DE2337068A1 (de) 1974-02-07

Family

ID=23046507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19732337068 Ceased DE2337068A1 (de) 1972-07-21 1973-07-20 1-benzylindenylsaeuren

Country Status (8)

Country Link
US (1) US3851063A (US07696358-20100413-C00002.png)
JP (1) JPS4943956A (US07696358-20100413-C00002.png)
CH (1) CH594590A5 (US07696358-20100413-C00002.png)
DE (1) DE2337068A1 (US07696358-20100413-C00002.png)
FR (1) FR2193596B1 (US07696358-20100413-C00002.png)
GB (1) GB1408964A (US07696358-20100413-C00002.png)
NL (1) NL7309424A (US07696358-20100413-C00002.png)
SE (1) SE7309354L (US07696358-20100413-C00002.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT380166B (de) * 1981-02-16 1986-04-25 Ciba Geigy Ag Verfahren zur herstellung topisch applizierbarer pharmazeutischer praeparate, enthaltend salze von alkancarbonsaeuren
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
WO2007081694A2 (en) * 2006-01-04 2007-07-19 Southern Research Institute Derivatives of sulindac, use thereof and preparation thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754556A (fr) * 1969-08-08 1971-02-08 Merck & Co Inc Acides indenyl-acetiques et procede pour les

Also Published As

Publication number Publication date
SE7309354L (US07696358-20100413-C00002.png) 1974-01-22
FR2193596B1 (US07696358-20100413-C00002.png) 1976-12-31
GB1408964A (en) 1975-10-08
JPS4943956A (US07696358-20100413-C00002.png) 1974-04-25
US3851063A (en) 1974-11-26
NL7309424A (US07696358-20100413-C00002.png) 1974-01-23
FR2193596A1 (US07696358-20100413-C00002.png) 1974-02-22
CH594590A5 (US07696358-20100413-C00002.png) 1978-01-13

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Legal Events

Date Code Title Description
OD Request for examination
8131 Rejection