DE2335826C2 - Peptide und deren Derivate sowie diese Verbindungen enthaltende Arzneimittel - Google Patents

Peptide und deren Derivate sowie diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2335826C2
DE2335826C2 DE2335826A DE2335826A DE2335826C2 DE 2335826 C2 DE2335826 C2 DE 2335826C2 DE 2335826 A DE2335826 A DE 2335826A DE 2335826 A DE2335826 A DE 2335826A DE 2335826 C2 DE2335826 C2 DE 2335826C2
Authority
DE
Germany
Prior art keywords
phe
boc
lys
glu
otbu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2335826A
Other languages
German (de)
English (en)
Other versions
DE2335826A1 (de
Inventor
Hendrik Marie Heesch Greven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of DE2335826A1 publication Critical patent/DE2335826A1/de
Application granted granted Critical
Publication of DE2335826C2 publication Critical patent/DE2335826C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE2335826A 1972-07-15 1973-07-13 Peptide und deren Derivate sowie diese Verbindungen enthaltende Arzneimittel Expired DE2335826C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7209839,A NL175618C (nl) 1972-07-15 1972-07-15 Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden.

Publications (2)

Publication Number Publication Date
DE2335826A1 DE2335826A1 (de) 1974-01-31
DE2335826C2 true DE2335826C2 (de) 1984-01-05

Family

ID=19816526

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2335826A Expired DE2335826C2 (de) 1972-07-15 1973-07-13 Peptide und deren Derivate sowie diese Verbindungen enthaltende Arzneimittel

Country Status (13)

Country Link
US (1) US3853838A (OSRAM)
JP (1) JPS5936611B2 (OSRAM)
AU (1) AU471401B2 (OSRAM)
BE (1) BE802335A (OSRAM)
CA (1) CA1019723A (OSRAM)
CH (1) CH605674A5 (OSRAM)
DE (1) DE2335826C2 (OSRAM)
FR (1) FR2192838B1 (OSRAM)
GB (1) GB1439225A (OSRAM)
HU (1) HU169437B (OSRAM)
NL (1) NL175618C (OSRAM)
SE (1) SE392721B (OSRAM)
ZA (1) ZA734648B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4144228A (en) * 1976-05-07 1979-03-13 G. D. Searle & Co. Methionine5 -enkephalin sulfoxides and sulfones
NL7607684A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4356119A (en) * 1978-09-28 1982-10-26 Nordisk Insulinlaboratorium Therapeutically active polypeptides or acid addition salts and a process for producing such compounds
US4623715A (en) * 1984-10-22 1986-11-18 Hoechst Aktiengeselleschaft Novel peptides which are active on the central nervous system and have an action on the cholinergic system
WO1986003746A1 (en) * 1984-12-14 1986-07-03 La Trobe University Amino acid and peptide inhibitors of human leucocytic elastase
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
RU2315057C2 (ru) * 2006-02-17 2008-01-20 Закрытое акционерное общество "Синтез пептидов" Способ получения аналогов аденокортикотропного гормона (актг), последовательности (4-10), обладающих нейротропной активностью, и тетрапептид для его получения
WO2011133348A1 (en) 2010-04-21 2011-10-27 Pharmacofore, Inc. Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
MX2023010506A (es) 2021-03-09 2023-09-20 Ensysce Biosciences Inc Composiciones que comprenden profarmacos de escision enzimatica y nafamostat de liberacion controlada y metodos de uso de estos.
CA3230025A1 (en) 2021-09-29 2023-04-06 Lynn Kirkpatrick Enzyme-cleavable methadone prodrugs and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL278010A (OSRAM) * 1961-05-04 1900-01-01
NL6509727A (OSRAM) * 1965-07-28 1967-01-30
GB1230472A (OSRAM) * 1967-07-10 1971-05-05

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
SE392721B (sv) 1977-04-18
FR2192838B1 (OSRAM) 1977-01-28
NL175618B (nl) 1984-07-02
BE802335A (fr) 1974-01-14
CH605674A5 (OSRAM) 1978-10-13
US3853838A (en) 1974-12-10
HU169437B (OSRAM) 1976-11-28
JPS5936611B2 (ja) 1984-09-05
CA1019723A (en) 1977-10-25
ZA734648B (en) 1974-06-26
AU471401B2 (en) 1976-04-29
GB1439225A (en) 1976-06-16
DE2335826A1 (de) 1974-01-31
FR2192838A1 (OSRAM) 1974-02-15
NL175618C (nl) 1984-12-03
AU5798373A (en) 1975-01-16
NL7209839A (OSRAM) 1974-01-17
JPS4951278A (OSRAM) 1974-05-18

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Legal Events

Date Code Title Description
OD Request for examination
8126 Change of the secondary classification

Ipc: A61K 37/02

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee