DE2330912C3 - Verfahren zur Herstellung von Bromergolinverbindungen - Google Patents

Verfahren zur Herstellung von Bromergolinverbindungen

Info

Publication number
DE2330912C3
DE2330912C3 DE2330912A DE2330912A DE2330912C3 DE 2330912 C3 DE2330912 C3 DE 2330912C3 DE 2330912 A DE2330912 A DE 2330912A DE 2330912 A DE2330912 A DE 2330912A DE 2330912 C3 DE2330912 C3 DE 2330912C3
Authority
DE
Germany
Prior art keywords
melting point
acid
compounds
methyl
bromergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2330912A
Other languages
German (de)
English (en)
Other versions
DE2330912B2 (de
DE2330912A1 (de
Inventor
Giuliana Dr. Arcari
Luigi Bernardi
Alfredo Dr. Med. Glaesser
Bianca Patelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of DE2330912A1 publication Critical patent/DE2330912A1/de
Publication of DE2330912B2 publication Critical patent/DE2330912B2/de
Application granted granted Critical
Publication of DE2330912C3 publication Critical patent/DE2330912C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE2330912A 1972-06-22 1973-06-18 Verfahren zur Herstellung von Bromergolinverbindungen Expired DE2330912C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2602472 1972-06-22

Publications (3)

Publication Number Publication Date
DE2330912A1 DE2330912A1 (de) 1974-01-17
DE2330912B2 DE2330912B2 (de) 1978-05-18
DE2330912C3 true DE2330912C3 (de) 1979-01-11

Family

ID=11218441

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2330912A Expired DE2330912C3 (de) 1972-06-22 1973-06-18 Verfahren zur Herstellung von Bromergolinverbindungen

Country Status (7)

Country Link
US (1) US3904634A (enExample)
JP (1) JPS4966699A (enExample)
CH (1) CH583233A5 (enExample)
DE (1) DE2330912C3 (enExample)
FR (1) FR2189046B1 (enExample)
GB (1) GB1413068A (enExample)
HU (1) HU165918B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076715A (en) * 1972-09-26 1978-02-28 Sandoz Ltd. 13-Bromo lysergic acid compounds
US4001242A (en) * 1974-08-02 1977-01-04 Eli Lilly And Company D-6-methyl-8-formyl-10α-alkoxy-8-ergolene
US4199579A (en) * 1975-03-14 1980-04-22 Siphar S. A. Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof
YU40004B (en) * 1977-07-21 1985-06-30 Lek Tovarna Farmacevtskih Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
AU553809B2 (en) * 1981-07-21 1986-07-31 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
DE3340025C2 (de) * 1983-11-03 1986-01-09 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
DE3730124A1 (de) * 1987-09-08 1989-03-16 Eich Eckart Neue festuclavin- und pyroclavin-derivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4914107A (en) * 1989-01-17 1990-04-03 Eli Lilly And Company Method for selectively blocking 5-HT2 receptors
DE3931819A1 (de) * 1989-09-20 1991-03-28 Schering Ag 13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236852A (en) * 1966-02-22 Esters of g-methyl- and i,g-dimethyl. ergoline
US3185695A (en) * 1965-05-25 Dbwethyl-ergoline ii derivatives
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US3228943A (en) * 1962-06-11 1966-01-11 Lumilysergol derivatives
FR1345864A (fr) * 1962-12-20 1963-12-13 Sandoz Sa Nouveaux composés hétérocycliques dérivant de l'acide lysergique et leur préparation
US3232942A (en) * 1964-06-02 1966-02-01 Sandoz Ltd 1-substituted (+)-lysergol

Also Published As

Publication number Publication date
US3904634A (en) 1975-09-09
GB1413068A (en) 1975-11-05
FR2189046B1 (enExample) 1978-07-28
DE2330912B2 (de) 1978-05-18
FR2189046A1 (enExample) 1974-01-25
HU165918B (enExample) 1974-12-28
DE2330912A1 (de) 1974-01-17
JPS4966699A (enExample) 1974-06-27
CH583233A5 (enExample) 1976-12-31

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee