DE69115138T2 - Verfahren zur herstellung von ergolinderivaten. - Google Patents

Verfahren zur herstellung von ergolinderivaten.

Info

Publication number
DE69115138T2
DE69115138T2 DE69115138T DE69115138T DE69115138T2 DE 69115138 T2 DE69115138 T2 DE 69115138T2 DE 69115138 T DE69115138 T DE 69115138T DE 69115138 T DE69115138 T DE 69115138T DE 69115138 T2 DE69115138 T2 DE 69115138T2
Authority
DE
Germany
Prior art keywords
pct
represents hydrogen
alkyl
image
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69115138T
Other languages
English (en)
Other versions
DE69115138D1 (de
Inventor
Sergio Mantegani
Gabriella Traquandi
Tiziano Bandiera
Enzo Brambilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909001774A external-priority patent/GB9001774D0/en
Priority claimed from GB909025849A external-priority patent/GB9025849D0/en
Application filed by Pharmacia SpA filed Critical Pharmacia SpA
Application granted granted Critical
Publication of DE69115138D1 publication Critical patent/DE69115138D1/de
Publication of DE69115138T2 publication Critical patent/DE69115138T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69115138T 1990-01-25 1991-01-21 Verfahren zur herstellung von ergolinderivaten. Expired - Fee Related DE69115138T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909001774A GB9001774D0 (en) 1990-01-25 1990-01-25 Process for preparing ergoline derivatives
GB909025849A GB9025849D0 (en) 1990-11-28 1990-11-28 Process for preparing ergoline derivatives
PCT/EP1991/000104 WO1991011447A1 (en) 1990-01-25 1991-01-21 Process for preparing ergoline derivatives

Publications (2)

Publication Number Publication Date
DE69115138D1 DE69115138D1 (de) 1996-01-18
DE69115138T2 true DE69115138T2 (de) 1996-05-09

Family

ID=26296553

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115138T Expired - Fee Related DE69115138T2 (de) 1990-01-25 1991-01-21 Verfahren zur herstellung von ergolinderivaten.

Country Status (21)

Country Link
US (1) US5210194A (de)
EP (1) EP0464178B1 (de)
JP (1) JPH04504582A (de)
KR (1) KR920701205A (de)
AT (1) ATE131167T1 (de)
AU (1) AU644625B2 (de)
CA (1) CA2049053A1 (de)
DE (1) DE69115138T2 (de)
DK (1) DK0464178T3 (de)
ES (1) ES2083564T3 (de)
FI (1) FI96113C (de)
GR (1) GR3019125T3 (de)
HU (1) HU208971B (de)
IE (1) IE72142B1 (de)
IL (1) IL96996A (de)
MY (1) MY106383A (de)
NO (1) NO178373C (de)
NZ (1) NZ236852A (de)
PT (1) PT96557B (de)
RU (1) RU2074857C1 (de)
WO (1) WO1991011447A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
PL304893A1 (en) * 1992-12-24 1995-01-09 Erba Carlo Spa Serotoninergic derivatives of ergoline
GB9407637D0 (en) 1994-04-18 1994-06-08 Erba Carlo Spa Serotoninergic abeo-ergoline derivatives
GB9603226D0 (en) * 1996-02-15 1996-04-17 Pharmacia Spa Heterocyclyl-ergoline derivatives
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives
HUP0400245A3 (en) 2001-06-08 2012-09-28 Ipsen Pharma Sas Somatostatin-dopamine chimeric analogs and pharmaceutical compositions containing them
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
JP2016503402A (ja) 2012-11-01 2016-02-04 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエＩｐｓｅｎ Ｐｈａｒｍａ Ｓ．Ａ．Ｓ． ソマトスタチン類似体及びそのダイマー

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763161A (en) * 1970-07-13 1973-10-02 Du Pont Tetrasubstituted dicyanopyrazines and related compounds
JPS58172012A (ja) * 1982-04-01 1983-10-08 Clarion Co Ltd 同一放送識別受信機
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
US4806538A (en) * 1984-11-02 1989-02-21 Fujisawa Pharmaceutical Co., Ltd. Piperazine compound as PAF-antagonist
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
DE3517247A1 (de) * 1985-05-13 1986-11-13 Gerhard Prof. Dr.-Ing. 8012 Ottobrunn Flachenecker Antennendiversity-empfangsanlage zur elimination von empfangsstoerungen
US4871736A (en) * 1986-11-25 1989-10-03 The Ohio State University Stereoisomeric tricyclic bis(dioxopiperazines) and pharmaceutical compositions
US4733402A (en) * 1987-04-23 1988-03-22 Signatron, Inc. Adaptive filter equalizer systems
DE3814899A1 (de) * 1988-05-03 1989-11-16 Hirschmann Richard Gmbh Co Empfangsverfahren und empfangs-antennensystem fuer mobilen empfang
NO175659C (no) * 1988-07-06 1994-11-09 Sumitomo Electric Industries Kommunikasjonssystem med multippelmottagning og mottagerapparat for diversitetssignaler
DE3926336C2 (de) * 1989-08-09 2001-03-29 Heinz Lindenmeier Antennendiversity-Empfangsanlage zur Elimination von Empfangsstörungen beim mobilen Empfang von Fernsehsignalen

Also Published As

Publication number Publication date
IL96996A (en) 1994-11-28
NO913647D0 (no) 1991-09-16
GR3019125T3 (en) 1996-05-31
NZ236852A (en) 1992-05-26
EP0464178A1 (de) 1992-01-08
ES2083564T3 (es) 1996-04-16
FI96113C (fi) 1996-05-10
AU7078891A (en) 1991-08-21
IE72142B1 (en) 1997-03-26
RU2074857C1 (ru) 1997-03-10
IL96996A0 (en) 1992-03-29
HUT58092A (en) 1992-01-28
DE69115138D1 (de) 1996-01-18
DK0464178T3 (da) 1996-01-02
JPH04504582A (ja) 1992-08-13
FI96113B (fi) 1996-01-31
WO1991011447A1 (en) 1991-08-08
IE910244A1 (en) 1991-07-31
PT96557A (pt) 1991-10-15
NO913647L (no) 1991-09-16
KR920701205A (ko) 1992-08-11
US5210194A (en) 1993-05-11
FI914458A0 (fi) 1991-09-23
EP0464178B1 (de) 1995-12-06
NO178373B (no) 1995-12-04
HU208971B (en) 1994-02-28
MY106383A (en) 1995-05-30
NO178373C (no) 1996-03-13
CA2049053A1 (en) 1991-07-26
PT96557B (pt) 1998-07-31
ATE131167T1 (de) 1995-12-15
AU644625B2 (en) 1993-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee