DE2305092A1 - Alpha-aminomethylbenzylalkoholderivate - Google Patents

Alpha-aminomethylbenzylalkoholderivate

Info

Publication number
DE2305092A1
DE2305092A1 DE19732305092 DE2305092A DE2305092A1 DE 2305092 A1 DE2305092 A1 DE 2305092A1 DE 19732305092 DE19732305092 DE 19732305092 DE 2305092 A DE2305092 A DE 2305092A DE 2305092 A1 DE2305092 A1 DE 2305092A1
Authority
DE
Germany
Prior art keywords
group
benzyl
alcohol
added
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19732305092
Other languages
German (de)
English (en)
Other versions
DE2305092C2 (ja
Inventor
Hisashi Ida
Toshiyasu Mase
Masuo Murakami
Kiyoshi Murase
Kozo Takahashi
Saitama Urawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1312172A external-priority patent/JPS5653537B2/ja
Priority claimed from JP3941672A external-priority patent/JPS49237A/ja
Priority claimed from JP5101372A external-priority patent/JPS495934A/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of DE2305092A1 publication Critical patent/DE2305092A1/de
Application granted granted Critical
Publication of DE2305092C2 publication Critical patent/DE2305092C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19732305092 1972-02-05 1973-02-02 Alpha-aminomethylbenzylalkoholderivate Granted DE2305092A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1312172A JPS5653537B2 (ja) 1972-02-05 1972-02-05
JP3941672A JPS49237A (ja) 1972-04-19 1972-04-19
JP5101372A JPS495934A (ja) 1972-05-23 1972-05-23
JP5291572 1972-05-27

Publications (2)

Publication Number Publication Date
DE2305092A1 true DE2305092A1 (de) 1973-08-16
DE2305092C2 DE2305092C2 (ja) 1987-10-01

Family

ID=27455936

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19732366625 Expired DE2366625C2 (ja) 1972-02-05 1973-02-02
DE19732305092 Granted DE2305092A1 (de) 1972-02-05 1973-02-02 Alpha-aminomethylbenzylalkoholderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19732366625 Expired DE2366625C2 (ja) 1972-02-05 1973-02-02

Country Status (1)

Country Link
DE (2) DE2366625C2 (ja)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072760A (en) * 1974-11-20 1978-02-07 Pharmacia As Bronchospasmolytic phenylethanolamines
EP0068669A1 (en) * 1981-06-20 1983-01-05 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0180994A2 (en) * 1984-11-08 1986-05-14 Syntex (U.S.A.) Inc. Antihypertensive dialkyl aminoethylaniline derivatives
US4975466A (en) * 1986-06-05 1990-12-04 Ciba-Geigy Corporation Pharmaceutical preparations for topical application and their use in the treatment of inflammatory skin diseases
EP0586344A1 (de) * 1992-09-02 1994-03-09 Ciba-Geigy Ag Oxazolidin Verbindungen und ihre Verwendung als Arzneimittel
LT3813B (en) 1990-09-26 1996-03-25 Astra Ab Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6576793B1 (en) 1999-12-08 2003-06-10 Theravance, Inc. β2-adrenergic receptor agonists
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US7348362B2 (en) 2003-07-10 2008-03-25 Dey, L.P. Bronchodilating β-agonist compositions and methods
WO2009032764A1 (en) 2007-08-28 2009-03-12 Sepracor Inc. Acetamide stereoisomer
US8173829B2 (en) 2007-08-28 2012-05-08 Sunovion Pharmaceuticals Inc. Carbamate stereoisomer
US8507670B2 (en) 2006-08-22 2013-08-13 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
US8623851B2 (en) 2001-04-17 2014-01-07 Mylan Specialty L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE739678A (fr) * 1969-10-01 1970-04-01 Amino-alcools et leur preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE739678A (fr) * 1969-10-01 1970-04-01 Amino-alcools et leur preparation

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072760A (en) * 1974-11-20 1978-02-07 Pharmacia As Bronchospasmolytic phenylethanolamines
EP0068669A1 (en) * 1981-06-20 1983-01-05 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0180994A2 (en) * 1984-11-08 1986-05-14 Syntex (U.S.A.) Inc. Antihypertensive dialkyl aminoethylaniline derivatives
EP0180994A3 (en) * 1984-11-08 1987-09-23 Syntex (U.S.A.) Inc. Antihypertensive dialkyl aminoethylaniline derivatives
US4975466A (en) * 1986-06-05 1990-12-04 Ciba-Geigy Corporation Pharmaceutical preparations for topical application and their use in the treatment of inflammatory skin diseases
LT3813B (en) 1990-09-26 1996-03-25 Astra Ab Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof
EP0586344A1 (de) * 1992-09-02 1994-03-09 Ciba-Geigy Ag Oxazolidin Verbindungen und ihre Verwendung als Arzneimittel
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6576793B1 (en) 1999-12-08 2003-06-10 Theravance, Inc. β2-adrenergic receptor agonists
US8716348B2 (en) 2001-04-17 2014-05-06 Dey Pharma, L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US8623851B2 (en) 2001-04-17 2014-01-07 Mylan Specialty L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US9597396B2 (en) 2001-04-17 2017-03-21 Mylan Specialty Lp Formoterol/steroid bronchodilating compositions and methods of use thereof
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US7462645B2 (en) 2003-07-10 2008-12-09 Jpmorgan Chase Bank, N.A. Bronchodilating beta-agonist compositions and methods
US7465756B2 (en) 2003-07-10 2008-12-16 Jpmorgan Chase Bank, N.A. Bronchodilating beta-agonist compositions and methods
US7473710B2 (en) 2003-07-10 2009-01-06 Jpmorgan Chase Bank, N.A. Bronchodilating beta-agonist compositions and methods
US9730890B2 (en) 2003-07-10 2017-08-15 Mylan Pharmaceuticals, Inc. Bronchodilating beta-agonist compositions and methods
US7541385B2 (en) 2003-07-10 2009-06-02 Chaudry Imtiaz A Bronchodilating β-agonist compositions and methods
US7348362B2 (en) 2003-07-10 2008-03-25 Dey, L.P. Bronchodilating β-agonist compositions and methods
US8846910B2 (en) 2006-08-22 2014-09-30 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
US8507670B2 (en) 2006-08-22 2013-08-13 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
US8816073B2 (en) 2006-08-22 2014-08-26 Ranbaxy Laboratories Limited Matrix metalloproteinase inhibitors
AU2008296458B2 (en) * 2007-08-28 2014-01-16 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US8664441B2 (en) 2007-08-28 2014-03-04 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
KR101398775B1 (ko) * 2007-08-28 2014-05-27 선오비온 파마슈티컬스 인코포레이티드 아세트아미드 입체이성체
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US9040588B2 (en) 2007-08-28 2015-05-26 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
TWI505826B (zh) * 2007-08-28 2015-11-01 Sepracor Inc 乙醯胺立體異構物
US9499476B2 (en) 2007-08-28 2016-11-22 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US8173829B2 (en) 2007-08-28 2012-05-08 Sunovion Pharmaceuticals Inc. Carbamate stereoisomer
WO2009032764A1 (en) 2007-08-28 2009-03-12 Sepracor Inc. Acetamide stereoisomer

Also Published As

Publication number Publication date
DE2305092C2 (ja) 1987-10-01
DE2366625C2 (ja) 1988-06-09

Similar Documents

Publication Publication Date Title
DE69100079T2 (de) Naphthalin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
DE69032020T2 (de) N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DD141520A5 (de) Verfahren zur herstellung neuer derivate von 4-amino-5-alkylsulfonyl-ortho-anisamiden
DE2305092A1 (de) Alpha-aminomethylbenzylalkoholderivate
DE9290063U1 (de) Chinuclidin-Derivate
CH631696A5 (de) Verfahren zur herstellung von olefinischen derivaten von aminosaeuren.
EP0929516A1 (de) Benzamidinderivate und ihre verwendung als arzneimittel mit ltb4-antagonistischer wirkung
DD216934A5 (de) Verfahren zur herstellung neuer derivate von xanthinen
DE2105743A1 (en) 2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents
DE2720085C2 (ja)
EP0521422B1 (de) Benzomorphane und ihre Verwendung als Arzneimittel
DE3586411T2 (de) Dopamin-antagoniste.
DE69002474T2 (de) Carboxyalkyl-ether von 2-Amino-7-hydroxytetralin.
EP0064685A1 (de) Dibenzo(de,g)chinolin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
CH622768A5 (ja)
CH640507A5 (en) Process for preparing novel 1-aryloxy-2-hydroxy-3-aminopropanes
DE2241241C3 (de) Thiazolo eckige klammer auf 3.2-a eckige klammer zu -pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CH624397A5 (ja)
EP0102929B1 (de) Propylamin-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
DE829894C (de) Verfahren zur Herstellung neuer Derivate von 1, 8-Naphthyridin-4-carbonsaeuren
DD215540A5 (de) Verfahren zur herstellung von benzazepinderivaten
DE1901167C3 (de) Substituierte Indole, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen
CH556323A (de) Verfahren zur herstellung von neuen naphthylalkylaminen.
DE2500919C3 (de) 5-(l-Allyl-2-pyrrolidinylmethylaminocarbonyl)-6-methoxy-benzotriazol sowie seine pharmazeutisch verträglichen Additionssalze mit Säuren
AT282593B (de) Verfahren zur herstellung von neuem racemischem oder optisch aktivem (1-2'-nitrilophenoxy)-2-hydroxy-3-isopropylaminopropan und dessen salzen

Legal Events

Date Code Title Description
OD Request for examination
8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 2366624

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 2366624

8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 2366625

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 2366625

AH Division in

Ref country code: DE

Ref document number: 2366625

Format of ref document f/p: P

D2 Grant after examination
8364 No opposition during term of opposition
AH Division in

Ref country code: DE

Ref document number: 2366625

Format of ref document f/p: P