DE2303247A1 - Verfahren zur herstellung von stoffgemischen fuer medizinische oder nahrungsmittelzwecke - Google Patents
Verfahren zur herstellung von stoffgemischen fuer medizinische oder nahrungsmittelzweckeInfo
- Publication number
- DE2303247A1 DE2303247A1 DE2303247A DE2303247A DE2303247A1 DE 2303247 A1 DE2303247 A1 DE 2303247A1 DE 2303247 A DE2303247 A DE 2303247A DE 2303247 A DE2303247 A DE 2303247A DE 2303247 A1 DE2303247 A1 DE 2303247A1
- Authority
- DE
- Germany
- Prior art keywords
- glycoside
- carrier
- glucoside
- steroid
- sitosteryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 239000000126 substance Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 8
- 239000000203 mixture Substances 0.000 title claims description 7
- 235000013305 food Nutrition 0.000 title claims description 5
- 239000000839 emulsion Substances 0.000 claims description 16
- 229930002534 steroid glycoside Natural products 0.000 claims description 16
- 239000003463 adsorbent Substances 0.000 claims description 14
- 239000002250 absorbent Substances 0.000 claims description 8
- 230000002745 absorbent Effects 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 229930182558 Sterol Natural products 0.000 claims description 6
- 150000003432 sterols Chemical class 0.000 claims description 6
- 235000003702 sterols Nutrition 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 5
- 150000003431 steroids Chemical class 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 claims description 2
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 claims description 2
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 claims description 2
- 150000002338 glycosides Chemical class 0.000 description 35
- 229930182470 glycoside Natural products 0.000 description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 18
- 239000002245 particle Substances 0.000 description 15
- 239000000454 talc Substances 0.000 description 14
- 229910052623 talc Inorganic materials 0.000 description 14
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 229910002012 Aerosil® Inorganic materials 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 229930182478 glucoside Natural products 0.000 description 7
- 150000008131 glucosides Chemical class 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 6
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000002002 slurry Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 229940076810 beta sitosterol Drugs 0.000 description 4
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 4
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 4
- 229950005143 sitosterol Drugs 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- PBAYDYUZOSNJGU-UHFFFAOYSA-N Chelidonic acid Chemical compound OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 2
- NPJICTMALKLTFW-NEOYQNEMSA-N Sitosteryl glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1OC(CO)[C@@H](O)C(O)C1O NPJICTMALKLTFW-NEOYQNEMSA-N 0.000 description 2
- 235000019486 Sunflower oil Nutrition 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- QHKKPRDTANXCBJ-UHFFFAOYSA-N beta-sitosterol-delta-glucopyranoside Natural products CCC(CCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)OC5OC(OC)C(O)C(O)C5O)C(C)C QHKKPRDTANXCBJ-UHFFFAOYSA-N 0.000 description 2
- YCHQFVUAIVWDNL-UHFFFAOYSA-N beta-sitosteryl-beta-D-glucoside Natural products CCC(CCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC2(C)C1)OC5OC(CO)C(O)C(O)C5O)C(C)C YCHQFVUAIVWDNL-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- FSMCJUNYLQOAIM-UQBZCTSOSA-N cholesteryl beta-D-glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FSMCJUNYLQOAIM-UQBZCTSOSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 150000002402 hexoses Chemical group 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 150000004760 silicates Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002600 sunflower oil Substances 0.000 description 2
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229940093797 bioflavonoids Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- -1 cholesteryl glucosides Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000012243 magnesium silicates Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA720698A ZA72698B (en) | 1972-02-03 | 1972-02-03 | Method of preparing medicinal compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2303247A1 true DE2303247A1 (de) | 1973-08-09 |
Family
ID=25564442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2303247A Ceased DE2303247A1 (de) | 1972-02-03 | 1973-01-24 | Verfahren zur herstellung von stoffgemischen fuer medizinische oder nahrungsmittelzwecke |
Country Status (12)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2375865A1 (fr) * | 1976-12-30 | 1978-07-28 | Roecar Holdings Nv | Compositions medicamenteuses contenant des sterolines et leurs applications therapeutiques |
| FR2542999A1 (fr) * | 1981-10-29 | 1984-09-28 | Nippon Shinyaku Co Ltd | Procede de fabrication de liposome contenant un ou plusieurs sterylglucosides et monopalmitates de sterylglucosides et nouveaux produits ainsi obtenus |
| EP0357967A1 (de) * | 1988-09-01 | 1990-03-14 | Roecar Holdings (Netherlands Antilles) N.V. | Phyto- und Zoosterole und deren Derivate mit verbesserter Wasserlöslichkeit |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR830005852A (ko) * | 1980-07-18 | 1983-09-14 | 미첼 페터 잭슨 | 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법 |
| EP0509656B1 (en) * | 1991-03-28 | 1996-09-18 | Rooperol (Na) Nv | Compositions of phytosterols and phytosterolins as immunmodulators |
| SE512958C2 (sv) | 1998-04-30 | 2000-06-12 | Triple Crown Ab | Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning |
| SE517769C2 (sv) | 1999-10-29 | 2002-07-16 | Triple Crown Ab | Kolesterol och blodfettsänkande komposition, innehållande fytosteroler, blandade med monoglycerider |
| US7306819B2 (en) | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| MXPA04012456A (es) | 2002-06-12 | 2005-02-17 | Coca Cola Co | Bebidas que contienen esteroles vegetales. |
| MY142989A (en) * | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| EP2238979A1 (en) * | 2009-04-06 | 2010-10-13 | LEK Pharmaceuticals d.d. | Active pharmaceutical ingredient adsorbed on solid support |
-
1972
- 1972-02-03 ZA ZA720698A patent/ZA72698B/xx unknown
-
1973
- 1973-01-02 GB GB13973A patent/GB1365661A/en not_active Expired
- 1973-01-10 CA CA160,948A patent/CA1028952A/en not_active Expired
- 1973-01-12 IE IE55/73A patent/IE37464B1/xx unknown
- 1973-01-12 AU AU51068/73A patent/AU468003B2/en not_active Expired
- 1973-01-12 BE BE794027D patent/BE794027A/xx not_active IP Right Cessation
- 1973-01-12 IL IL41289A patent/IL41289A/xx unknown
- 1973-01-18 ES ES410733A patent/ES410733A1/es not_active Expired
- 1973-01-24 DE DE2303247A patent/DE2303247A1/de not_active Ceased
- 1973-01-30 NL NL7301301A patent/NL7301301A/xx not_active Application Discontinuation
- 1973-02-02 FR FR7303776A patent/FR2173987B1/fr not_active Expired
- 1973-02-05 AT AT99173*#A patent/AT332530B/de not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2375865A1 (fr) * | 1976-12-30 | 1978-07-28 | Roecar Holdings Nv | Compositions medicamenteuses contenant des sterolines et leurs applications therapeutiques |
| FR2542999A1 (fr) * | 1981-10-29 | 1984-09-28 | Nippon Shinyaku Co Ltd | Procede de fabrication de liposome contenant un ou plusieurs sterylglucosides et monopalmitates de sterylglucosides et nouveaux produits ainsi obtenus |
| EP0357967A1 (de) * | 1988-09-01 | 1990-03-14 | Roecar Holdings (Netherlands Antilles) N.V. | Phyto- und Zoosterole und deren Derivate mit verbesserter Wasserlöslichkeit |
| DE3829643A1 (de) * | 1988-09-01 | 1990-03-15 | Roecar Holdings Nv | Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit |
| GR890100518A (en) * | 1988-09-01 | 1990-10-31 | Roecar Holdings Nv | Phyto-and zoosteroles and their substitutes soluble in water |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1028952A (en) | 1978-04-04 |
| IL41289A (en) | 1975-12-31 |
| BE794027A (fr) | 1973-05-02 |
| IE37464B1 (en) | 1977-08-03 |
| FR2173987B1 (enrdf_load_stackoverflow) | 1977-10-28 |
| GB1365661A (en) | 1974-09-04 |
| IE37464L (en) | 1973-08-03 |
| FR2173987A1 (enrdf_load_stackoverflow) | 1973-10-12 |
| ZA72698B (en) | 1973-09-26 |
| IL41289A0 (en) | 1973-03-30 |
| AU468003B2 (en) | 1975-12-18 |
| AT332530B (de) | 1976-10-11 |
| AU5106873A (en) | 1974-07-18 |
| ES410733A1 (es) | 1976-04-01 |
| ATA99173A (de) | 1976-01-15 |
| NL7301301A (enrdf_load_stackoverflow) | 1973-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE102007054702B4 (de) | Verfahren zur Herstellung von cellulosischen Formkörpern, cellulosischer Formkörper und dessen Verwendung | |
| DE3224619C2 (enrdf_load_stackoverflow) | ||
| DE60114467T2 (de) | Zubereitungen enthaltend ein steroidhormon und ein stabilisierungsmittel in nicht-kristalliner form | |
| DE2303247A1 (de) | Verfahren zur herstellung von stoffgemischen fuer medizinische oder nahrungsmittelzwecke | |
| EP1890804A1 (de) | Verwendung von stevensit zur mykotoxinadsorption | |
| CH689139A5 (de) | Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung. | |
| DE2725390A1 (de) | Dragee und verfahren zu seiner herstellung | |
| EP2089468B1 (de) | Verfahren zur herstellung von funktionellen cellulosischen formkörpern | |
| DE3001842C2 (enrdf_load_stackoverflow) | ||
| DE3852409T2 (de) | Aus Phospholipiden bestehende Darreichungsform für wasserunlösliche Wirksubstanzen. | |
| DE1813708A1 (de) | Verfahren zum Entseuchen von radioaktiven Fluessigkeiten | |
| EP3412299A1 (de) | Eintopf-verfahren bei der herstellung von spezialextrakten aus symphytum | |
| EP0604861A1 (de) | Verfahren zur Herstellung von Sorptionsmitteln auf smektitbasis zur Aufnahme von Flüssigkeiten | |
| DE1043588B (de) | Enterale UEberzugsmischungen | |
| DE69917446T2 (de) | Verfahren zum Herstellen von Kapseln und Tabletten aus Naturstoffen pflanzlichen Ursprungs | |
| DE1917930A1 (de) | Verfahren zum Herstellen von Kuegelchen aus festem Stoff | |
| EP2854823B1 (de) | Tonmineral zur reduzierung von anorganischen phosphaten, insbesondere im rahmen einer nierenersatztherapie | |
| DE2842608C2 (de) | Verfahren zur Herstellung von injizierbaren Liposomen | |
| DE2423466A1 (de) | Eingekapselte formulierung einer organischen persaeure | |
| DE10357541B4 (de) | Verfahren zur Erzeugung eines leicht aufrührbaren Sedimentes aus smektitischen Tonmineralien, insbesondere Bentonit, in wässrigen Medien | |
| DE10237517B4 (de) | Verfahren zur An- bzw. Abreicherung von Biomolekülen aus flüssigen oder fluiden Medien unter Verwendung von Schichtdoppelhydroxiden und Verwendung von an einem Schichtdoppelhydroxid an- oder eingelagerten Biomolekülen als anorganischer Vektor | |
| DE2250303A1 (de) | Verfahren zur herstellung von granulatteilchen mit biocider wirksamkeit | |
| DE2703600C2 (de) | Verfahren zur Herstellung einer Röntgenkontrastmittelsuspension | |
| DE1617302C (de) | Verfahren zur Herstellung eines einen Wismut Polygalacturon Komplex enthaltenden Gemische | |
| AT114615B (de) | Verfahren zur Herstellung von Medikamenten in Pillen- oder Tablettenform, welche den Magen unverändert passieren und erst im Darm zur Wirkung gelangen sollen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8131 | Rejection |