DE2234479C3 - Verfahren zur Herstellung von 3-Halogenmethyl^-acylamido^-methoxy^cephem-4-carbonsäure-Verbindungen - Google Patents

Verfahren zur Herstellung von 3-Halogenmethyl^-acylamido^-methoxy^cephem-4-carbonsäure-Verbindungen

Info

Publication number
DE2234479C3
DE2234479C3 DE2234479A DE2234479A DE2234479C3 DE 2234479 C3 DE2234479 C3 DE 2234479C3 DE 2234479 A DE2234479 A DE 2234479A DE 2234479 A DE2234479 A DE 2234479A DE 2234479 C3 DE2234479 C3 DE 2234479C3
Authority
DE
Germany
Prior art keywords
methoxy
cephem
carboxylic acid
acylamido
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2234479A
Other languages
German (de)
English (en)
Other versions
DE2234479B2 (de
DE2234479A1 (de
Inventor
Theresa Yupei Rahway Cheng Geb. Chen
Sandor Mountainside Karady
Seemon Hayden Murray Hill Pines
Meyer North Plainfield Sletzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US162703A external-priority patent/US3859282A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2234479A1 publication Critical patent/DE2234479A1/de
Publication of DE2234479B2 publication Critical patent/DE2234479B2/de
Application granted granted Critical
Publication of DE2234479C3 publication Critical patent/DE2234479C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE2234479A 1971-07-14 1972-07-13 Verfahren zur Herstellung von 3-Halogenmethyl^-acylamido^-methoxy^cephem-4-carbonsäure-Verbindungen Expired DE2234479C3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US162703A US3859282A (en) 1971-07-14 1971-07-14 Process for preparing 3-substituted methyl-7-acylamido-7-methoxy-2-cephem-4-carboxylic acid and its esters
US17955971A 1971-09-10 1971-09-10
US20121071A 1971-11-22 1971-11-22
US24427072A 1972-04-14 1972-04-14

Publications (3)

Publication Number Publication Date
DE2234479A1 DE2234479A1 (de) 1973-02-15
DE2234479B2 DE2234479B2 (de) 1975-05-22
DE2234479C3 true DE2234479C3 (de) 1976-01-02

Family

ID=27496523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2234479A Expired DE2234479C3 (de) 1971-07-14 1972-07-13 Verfahren zur Herstellung von 3-Halogenmethyl^-acylamido^-methoxy^cephem-4-carbonsäure-Verbindungen

Country Status (9)

Country Link
AU (1) AU464944B2 (xx)
BE (1) BE785917A (xx)
CA (1) CA1014949A (xx)
CH (1) CH583739A5 (xx)
DD (2) DD108542A5 (xx)
DE (1) DE2234479C3 (xx)
FR (2) FR2154425B1 (xx)
GB (1) GB1379465A (xx)
NL (1) NL7208855A (xx)

Also Published As

Publication number Publication date
FR2162237A1 (xx) 1973-07-13
FR2154425B1 (xx) 1973-12-07
CH583739A5 (xx) 1977-01-14
DE2234479B2 (de) 1975-05-22
BE785917A (fr) 1973-01-08
AU464944B2 (en) 1975-09-11
CA1014949A (en) 1977-08-02
FR2154425A1 (xx) 1973-05-11
DD108542A5 (xx) 1974-09-20
AU4420772A (en) 1974-01-10
FR2162237B1 (xx) 1974-03-15
NL7208855A (xx) 1973-01-16
DD105452A5 (xx) 1974-04-20
GB1379465A (en) 1975-01-02
DE2234479A1 (de) 1973-02-15

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977
EHJ Ceased/non-payment of the annual fee