DE2221546A1 - Verfahren zur Herstellung von neuen Imidazolderivaten - Google Patents

Verfahren zur Herstellung von neuen Imidazolderivaten

Info

Publication number
DE2221546A1
DE2221546A1 DE19722221546 DE2221546A DE2221546A1 DE 2221546 A1 DE2221546 A1 DE 2221546A1 DE 19722221546 DE19722221546 DE 19722221546 DE 2221546 A DE2221546 A DE 2221546A DE 2221546 A1 DE2221546 A1 DE 2221546A1
Authority
DE
Germany
Prior art keywords
pyridyl
imidazole
tert
butyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19722221546
Other languages
German (de)
English (en)
Inventor
Konrad Dr Fitzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH687571A external-priority patent/CH554415A/xx
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of DE2221546A1 publication Critical patent/DE2221546A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19722221546 1971-05-10 1972-05-03 Verfahren zur Herstellung von neuen Imidazolderivaten Withdrawn DE2221546A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH687571A CH554415A (de) 1970-06-01 1971-05-10 Verfahren zur herstellung von zitronensaeure durch submerse gaerung.
CH696771A CH561202A5 (ko) 1971-05-10 1971-05-11
CH697571 1971-05-12
CH425072A CH579072A5 (ko) 1971-05-10 1972-03-22

Publications (1)

Publication Number Publication Date
DE2221546A1 true DE2221546A1 (de) 1972-11-16

Family

ID=27428754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19722221546 Withdrawn DE2221546A1 (de) 1971-05-10 1972-05-03 Verfahren zur Herstellung von neuen Imidazolderivaten

Country Status (10)

Country Link
AT (4) AT319939B (ko)
AU (1) AU472065B2 (ko)
BE (1) BE783244A (ko)
CA (1) CA1012148A (ko)
CH (5) CH561718A5 (ko)
DE (1) DE2221546A1 (ko)
FR (1) FR2137740B1 (ko)
GB (1) GB1381031A (ko)
NL (1) NL7206346A (ko)
SE (1) SE405731B (ko)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045081A2 (de) * 1980-07-25 1982-02-03 Ciba-Geigy Ag Neue trisubstituierte Imidazolderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Verwendung
EP0074018A2 (de) * 1981-09-01 1983-03-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyridin- und Pyrazin-Derivate, Herstellung dieser Verbindungen, fungizide Mittel, die diese Verbindungen als Wirkstoffe enthalten, Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Fungi in der Landwirtschaft und im Gartenbau sowie Ketone und diese enthaltende fungizide Mittel
EP0257897A1 (en) * 1986-08-15 1988-03-02 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors
ES2053401A1 (es) * 1992-01-13 1994-07-16 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
WO1996018626A1 (en) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
WO1998047871A1 (en) * 1997-04-18 1998-10-29 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
US6127545A (en) * 1997-04-18 2000-10-03 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
US6130334A (en) * 1998-04-15 2000-10-10 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
US6268370B1 (en) 1992-01-13 2001-07-31 Smithkline Beecham Corporation Compounds
WO2001062756A1 (en) * 2000-02-21 2001-08-30 Smithkline Beecham P.L.C. Pyridinylimidazoles

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK513580A (da) * 1980-01-07 1981-07-08 Du Pont Fremgangsmaade til fremstilling af 4,5-diaryl-alfa (polyhalogenalkyl)-1h-imidazol-2-methanoler
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
WO1983002613A1 (en) * 1981-07-20 1983-08-04 Sallmann, Alfred Trisubstituted oxazo compounds
EP0084756A1 (de) * 1982-01-22 1983-08-03 Ciba-Geigy Ag Trisubstituierte Oxazaverbindungen
EP0084757A1 (de) * 1982-01-25 1983-08-03 Ciba-Geigy Ag Trisubstituierte Diaza-Derivate
JPH09505055A (ja) * 1993-11-08 1997-05-20 スミスクライン・ビーチャム・コーポレイション サイトカイン媒介疾患治療用オキサゾール
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US6426360B1 (en) * 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
ES2187473T3 (es) * 1999-04-09 2003-06-16 Smithkline Beecham Corp Triarylimidazoles.
GB0007405D0 (en) * 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192211A (en) * 1962-05-03 1965-06-29 Nl Combinatie Chem Ind 5-phenyl-5-(2-pyrazyl)-hydantoin
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045081A3 (en) * 1980-07-25 1982-04-07 Ciba-Geigy Ag Trisubstituted imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use
EP0045081A2 (de) * 1980-07-25 1982-02-03 Ciba-Geigy Ag Neue trisubstituierte Imidazolderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Verwendung
EP0074018A2 (de) * 1981-09-01 1983-03-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyridin- und Pyrazin-Derivate, Herstellung dieser Verbindungen, fungizide Mittel, die diese Verbindungen als Wirkstoffe enthalten, Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Fungi in der Landwirtschaft und im Gartenbau sowie Ketone und diese enthaltende fungizide Mittel
EP0074018A3 (en) * 1981-09-01 1983-12-28 F. Hoffmann-La Roche & Co. Aktiengesellschaft Pyridine and pyrazine derivatives, process for the preparation of these compounds, fungicides containing these compounds as active substances, use of these compounds or fungicides to combat fungi in agriculture and in horticulture, and ketones and fungicides containing them
EP0257897A1 (en) * 1986-08-15 1988-03-02 Fujisawa Pharmaceutical Co., Ltd. Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0943616A1 (en) * 1992-01-13 1999-09-22 Smithkline Beecham Corporation Substituted imidazole derivatives and their use as cytokine inhibitors
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors
ES2053401A1 (es) * 1992-01-13 1994-07-16 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
US6268370B1 (en) 1992-01-13 2001-07-31 Smithkline Beecham Corporation Compounds
US5686455A (en) * 1992-01-13 1997-11-11 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US5959113A (en) * 1994-12-13 1999-09-28 Hoffmann-La Roche Inc. Imidazol derivatives
WO1996018626A1 (en) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase
WO1998047871A1 (en) * 1997-04-18 1998-10-29 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
US6127545A (en) * 1997-04-18 2000-10-03 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
US6130334A (en) * 1998-04-15 2000-10-10 Merck & Co., Inc. Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors
WO2001062756A1 (en) * 2000-02-21 2001-08-30 Smithkline Beecham P.L.C. Pyridinylimidazoles

Also Published As

Publication number Publication date
AU472065B2 (en) 1976-05-13
CA1012148A (en) 1977-06-14
AT319940B (de) 1975-01-10
CH561716A5 (ko) 1975-05-15
SE405731B (sv) 1978-12-27
CH561202A5 (ko) 1975-04-30
CH579072A5 (ko) 1976-08-31
AU4205572A (en) 1973-11-15
BE783244A (fr) 1972-11-10
AT316544B (de) 1974-07-10
GB1381031A (en) 1975-01-22
FR2137740B1 (ko) 1975-08-01
FR2137740A1 (ko) 1972-12-29
AT319939B (de) 1975-01-10
AT319941B (de) 1975-01-10
CH561717A5 (ko) 1975-05-15
NL7206346A (ko) 1972-11-14
CH561718A5 (ko) 1975-05-15

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