DE2216072C2 - Verfahren zur Herstellung von Brausetabletten - Google Patents
Verfahren zur Herstellung von BrausetablettenInfo
- Publication number
- DE2216072C2 DE2216072C2 DE2216072A DE2216072A DE2216072C2 DE 2216072 C2 DE2216072 C2 DE 2216072C2 DE 2216072 A DE2216072 A DE 2216072A DE 2216072 A DE2216072 A DE 2216072A DE 2216072 C2 DE2216072 C2 DE 2216072C2
- Authority
- DE
- Germany
- Prior art keywords
- drying
- mixture
- effervescent
- water
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 13
- 239000007938 effervescent tablet Substances 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000000203 mixture Substances 0.000 claims description 49
- 238000001035 drying Methods 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 2
- 150000001447 alkali salts Chemical class 0.000 claims description 2
- 235000011089 carbon dioxide Nutrition 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000003765 sweetening agent Substances 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 239000007911 effervescent powder Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 22
- 239000008187 granular material Substances 0.000 description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 11
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 7
- 229960005489 paracetamol Drugs 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
- 229960001138 acetylsalicylic acid Drugs 0.000 description 5
- 229960004543 anhydrous citric acid Drugs 0.000 description 5
- 235000010323 ascorbic acid Nutrition 0.000 description 5
- 239000011668 ascorbic acid Substances 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 238000005469 granulation Methods 0.000 description 5
- 230000003179 granulation Effects 0.000 description 5
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 229960004106 citric acid Drugs 0.000 description 4
- 235000018342 monosodium citrate Nutrition 0.000 description 4
- 239000002524 monosodium citrate Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 235000019154 vitamin C Nutrition 0.000 description 4
- 239000011718 vitamin C Substances 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 description 2
- 239000011736 potassium bicarbonate Substances 0.000 description 2
- 229910001414 potassium ion Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical group CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- WNEFDHCAKLWKAG-UHFFFAOYSA-N acetic acid;2-hydroxybenzoic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1O WNEFDHCAKLWKAG-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- MWOBKFYERIDQSZ-UHFFFAOYSA-N benzene;sodium Chemical compound [Na].C1=CC=CC=C1 MWOBKFYERIDQSZ-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 241001233037 catfish Species 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Seasonings (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7112175A FR2132521A1 (en) | 1971-04-06 | 1971-04-06 | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
| FR7135069A FR2154323A1 (en) | 1971-09-29 | 1971-09-29 | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2216072A1 DE2216072A1 (de) | 1972-10-19 |
| DE2216072C2 true DE2216072C2 (de) | 1983-02-17 |
Family
ID=26216312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2216072A Expired DE2216072C2 (de) | 1971-04-06 | 1972-04-01 | Verfahren zur Herstellung von Brausetabletten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3773922A (OSRAM) |
| JP (1) | JPS5734249B1 (OSRAM) |
| AU (1) | AU464567B2 (OSRAM) |
| BE (1) | BE781358A (OSRAM) |
| CA (1) | CA978477A (OSRAM) |
| CH (1) | CH571322A5 (OSRAM) |
| DE (1) | DE2216072C2 (OSRAM) |
| DK (1) | DK132988C (OSRAM) |
| ES (1) | ES401283A1 (OSRAM) |
| GB (1) | GB1359614A (OSRAM) |
| NL (1) | NL176742C (OSRAM) |
| SE (1) | SE378988B (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887700A (en) * | 1969-11-28 | 1975-06-03 | Aspro Nicholas Ltd | Analgesic formulations |
| US4028239A (en) * | 1973-06-03 | 1977-06-07 | Lonza Ltd. | Process for preventing lime deposits in a humidifier |
| IT1049886B (it) * | 1975-11-28 | 1981-02-10 | Bayer Italia Spa | Processo per la preparazione di un granulato zucchero arancio es senzialmente anidro e non idrolizzante e suo impiego come componente di combinazioni con sostanze attive sensibili alla idrolisi |
| GB2058562B (en) * | 1979-09-14 | 1983-11-30 | Beecham Group Ltd | Pharmaceutical compositions containing paracetamol and ascorbic acid |
| US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| CA1182049A (en) * | 1981-07-13 | 1985-02-05 | Francis J. Sterbenz | Apap antacid composition |
| CA1209040A (fr) * | 1982-12-21 | 1986-08-05 | Jean Bru | Procede de fabrication de granules et comprimes effervescents |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| US4725427A (en) * | 1984-03-13 | 1988-02-16 | Albion International, Inc. | Effervescent vitamin-mineral granule preparation |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| JPS61183219A (ja) * | 1985-02-07 | 1986-08-15 | Takeda Chem Ind Ltd | 発泡組成物の製造法 |
| WO1986004599A1 (fr) * | 1985-02-07 | 1986-08-14 | Takeda Chemical Industries, Ltd. | Procede de production de compositions moussantes |
| US4687662A (en) * | 1985-08-30 | 1987-08-18 | Warner-Lambert Company | Therapeutic effervescent composition |
| US5130140A (en) * | 1989-09-14 | 1992-07-14 | Hoeschst-Roussel Pharmaceuticals Inc. | Method of making direct dry compressible acetaminophen composition |
| US5198228A (en) * | 1989-09-14 | 1993-03-30 | Hoechst-Roussel Pharmaceuticals Inc. | Direct dry compressible acetaminophen tablet |
| US5037658A (en) * | 1989-09-14 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Direct dry compressible acetaminophen composition |
| DE4027927A1 (de) * | 1990-09-04 | 1992-03-05 | Bayer Ag | Brausekomponente und verfahren zu ihrer herstellung |
| US5085852A (en) * | 1991-04-19 | 1992-02-04 | The Procter & Gamble Company | Antimicrobial oral compositions |
| JP3361111B2 (ja) | 1991-10-04 | 2003-01-07 | 北興化学工業株式会社 | 水面施用発泡性農薬製剤 |
| US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| US5665388A (en) * | 1995-11-13 | 1997-09-09 | Health Corporation | Method for preparation of an alkaline and aspirin combination compound |
| EP1191092A1 (en) * | 2000-09-25 | 2002-03-27 | Givaudan SA | Granulated composition |
| US20030229333A1 (en) * | 2002-02-22 | 2003-12-11 | Control Delivery Systems, Inc. | Methods for treating otic disorders |
| US7908765B2 (en) * | 2006-12-22 | 2011-03-22 | Collette Nv | Continuous granulating and drying apparatus |
| US8580853B2 (en) | 2011-06-13 | 2013-11-12 | Howard PHYKITT | Analgesic composition and method of making the same |
| WO2013022410A2 (en) | 2011-08-08 | 2013-02-14 | Mahmut Bilgic | Production method for effervescent formulations comprising dexketoprofen |
| WO2013115745A1 (en) * | 2012-01-31 | 2013-08-08 | Mahmut Bilgic | A process for production of pharmaceutical (effervescent) composition comprising alpha - glucosidase inhibitor (e.g. vogliobose and metformin) |
| HRP20171582T1 (hr) * | 2013-10-23 | 2017-12-01 | Bayer Healthcare Llc | Šumeća tableta koja sadrži visoku razinu aspirina |
| JP6566450B2 (ja) | 2014-09-17 | 2019-08-28 | ステアライフ・インディア・プライベート・リミテッド | 発泡組成物及びそれを製造する方法 |
| WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| CN111436610A (zh) * | 2020-05-12 | 2020-07-24 | 江苏慧博生物科技有限公司 | 一种竹叶黄酮红枣泡腾片及其制备方法 |
-
1972
- 1972-03-24 GB GB1381672A patent/GB1359614A/en not_active Expired
- 1972-03-28 CA CA138,565A patent/CA978477A/en not_active Expired
- 1972-03-28 ES ES401283A patent/ES401283A1/es not_active Expired
- 1972-03-29 BE BE781358A patent/BE781358A/xx not_active IP Right Cessation
- 1972-04-01 DE DE2216072A patent/DE2216072C2/de not_active Expired
- 1972-04-04 AU AU40683/72A patent/AU464567B2/en not_active Expired
- 1972-04-05 NL NLAANVRAGE7204524,A patent/NL176742C/xx not_active IP Right Cessation
- 1972-04-05 SE SE7204343A patent/SE378988B/xx unknown
- 1972-04-05 DK DK165072A patent/DK132988C/da active
- 1972-04-06 US US00241772A patent/US3773922A/en not_active Expired - Lifetime
- 1972-04-06 CH CH505072A patent/CH571322A5/xx not_active IP Right Cessation
- 1972-04-06 JP JP3481672A patent/JPS5734249B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK132988C (da) | 1976-08-09 |
| AU4068372A (en) | 1973-10-11 |
| SE378988B (OSRAM) | 1975-09-22 |
| US3773922A (en) | 1973-11-20 |
| NL7204524A (OSRAM) | 1972-10-10 |
| DE2216072A1 (de) | 1972-10-19 |
| ES401283A1 (es) | 1975-10-01 |
| NL176742B (nl) | 1985-01-02 |
| CH571322A5 (OSRAM) | 1976-01-15 |
| BE781358A (fr) | 1972-07-17 |
| AU464567B2 (en) | 1975-08-28 |
| GB1359614A (en) | 1974-07-10 |
| JPS5734249B1 (OSRAM) | 1982-07-22 |
| DK132988B (da) | 1976-03-08 |
| NL176742C (nl) | 1985-06-03 |
| CA978477A (en) | 1975-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| 8125 | Change of the main classification | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |