DE2210687C3 - 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel - Google Patents

2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Info

Publication number
DE2210687C3
DE2210687C3 DE2210687A DE2210687A DE2210687C3 DE 2210687 C3 DE2210687 C3 DE 2210687C3 DE 2210687 A DE2210687 A DE 2210687A DE 2210687 A DE2210687 A DE 2210687A DE 2210687 C3 DE2210687 C3 DE 2210687C3
Authority
DE
Germany
Prior art keywords
diamino
ooc
cooc
ethanol
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2210687A
Other languages
German (de)
English (en)
Other versions
DE2210687B2 (de
DE2210687A1 (de
Inventor
Friedrich Dr. 5600 Wuppertal Bossert
Kurt Dr. 5600 Wuppertal Stoepel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE2210687A priority Critical patent/DE2210687C3/de
Priority to RO73832A priority patent/RO61192A/ro
Priority to RO7300082647A priority patent/RO63068A/ro
Priority to DD169048A priority patent/DD106833A5/xx
Priority to BG24472A priority patent/BG20583A3/xx
Priority to US00336483A priority patent/US3855231A/en
Priority to BG22858A priority patent/BG22815A3/xx
Priority to JP2445273A priority patent/JPS5626659B2/ja
Priority to CH313273A priority patent/CH580589A5/xx
Priority to CH220176A priority patent/CH577473A5/xx
Priority to LU67147A priority patent/LU67147A1/xx
Priority to FI657/73A priority patent/FI55996C/fi
Priority to IL7341664A priority patent/IL41664A/en
Priority to PL1973161010A priority patent/PL89256B1/pl
Priority to PL1973182270A priority patent/PL92078B1/pl
Priority to KR7300356A priority patent/KR780000119B1/ko
Priority to IE346/73A priority patent/IE37370B1/xx
Priority to DK118073A priority patent/DK136061C/da
Priority to CA165,209A priority patent/CA988524A/en
Priority to SE7303021A priority patent/SE384208B/xx
Priority to ES412323A priority patent/ES412323A1/es
Priority to BE128374A priority patent/BE796279A/xx
Priority to ZA731501A priority patent/ZA731501B/xx
Priority to CS7500003602A priority patent/CS182792B2/cs
Priority to AT925774A priority patent/ATA925774A/de
Priority to HUBA2892A priority patent/HU167089B/hu
Priority to AT925774*7A priority patent/AT327904B/de
Priority to AT197373A priority patent/AT324338B/de
Priority to GB1075973A priority patent/GB1379005A/en
Priority to FR7307923A priority patent/FR2181789B1/fr
Priority to CS7300001593A priority patent/CS182781B2/cs
Priority to NL7303137A priority patent/NL7303137A/xx
Publication of DE2210687A1 publication Critical patent/DE2210687A1/de
Priority to US455257A priority patent/US3860601A/en
Priority to US05/454,996 priority patent/US3950336A/en
Priority to US454997A priority patent/US3887558A/en
Priority to US05/455,258 priority patent/US3957998A/en
Priority to US05/523,357 priority patent/US3959474A/en
Priority to US05/544,837 priority patent/US4049662A/en
Priority to US05/554,135 priority patent/US4016277A/en
Priority to DK365775A priority patent/DK365775A/da
Publication of DE2210687B2 publication Critical patent/DE2210687B2/de
Priority to JP55185147A priority patent/JPS5911584B2/ja
Application granted granted Critical
Publication of DE2210687C3 publication Critical patent/DE2210687C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE2210687A 1972-03-06 1972-03-06 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel Expired DE2210687C3 (de)

Priority Applications (41)

Application Number Priority Date Filing Date Title
DE2210687A DE2210687C3 (de) 1972-03-06 1972-03-06 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
RO73832A RO61192A (ja) 1972-03-06 1973-02-13
RO7300082647A RO63068A (ja) 1972-03-06 1973-02-13
DD169048A DD106833A5 (ja) 1972-03-06 1973-02-26
US00336483A US3855231A (en) 1972-03-06 1973-02-28 2,6-diamino-1,4-dihydropyridine derivatives
BG22858A BG22815A3 (ja) 1972-03-06 1973-02-28
BG24472A BG20583A3 (ja) 1972-03-06 1973-02-28
JP2445273A JPS5626659B2 (ja) 1972-03-06 1973-03-02
CH313273A CH580589A5 (ja) 1972-03-06 1973-03-02
CH220176A CH577473A5 (ja) 1972-03-06 1973-03-02
LU67147A LU67147A1 (ja) 1972-03-06 1973-03-02
FI657/73A FI55996C (fi) 1972-03-06 1973-03-02 Foerfarande foer framstaellning av 2,6-diamino-dihydropyridiner
IL7341664A IL41664A (en) 1972-03-06 1973-03-02 2,6-Diamino-dihydropyridines and their pharmaceutical preparations
PL1973182270A PL92078B1 (ja) 1972-03-06 1973-03-03
PL1973161010A PL89256B1 (ja) 1972-03-06 1973-03-03
BE128374A BE796279A (fr) 1972-03-06 1973-03-05 Procede de preparation de nouvelles 2,6-diamino-dihydropyridines
DK118073A DK136061C (da) 1972-03-06 1973-03-05 Fremgangsmade til fremstilling af 2,6-diamino-dihydropyridiner
CA165,209A CA988524A (en) 1972-03-06 1973-03-05 Process for the preparation of 2,6-diamino-1,4-dihydropyridine derivatives
SE7303021A SE384208B (sv) 1972-03-06 1973-03-05 Sett att framstella nya 2,6-diamino-dihydropyridiner
ES412323A ES412323A1 (es) 1972-03-06 1973-03-05 Procedimiento para la obtencion de 2,6-diaminodihidropiri- dinas.
KR7300356A KR780000119B1 (en) 1972-03-06 1973-03-05 New 2.6-diamino-dihydropyridines, their production, and their medicinal use
ZA731501A ZA731501B (en) 1972-03-06 1973-03-05 New 2,6-diamino-dihydropyridines,their production,and their medicinal use
IE346/73A IE37370B1 (en) 1972-03-06 1973-03-05 New 2,6-diamino-dihydropyridines their production and their medicinal use
AT925774A ATA925774A (de) 1972-03-06 1973-03-06 Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen
HUBA2892A HU167089B (ja) 1972-03-06 1973-03-06
AT925774*7A AT327904B (de) 1972-03-06 1973-03-06 Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen
AT197373A AT324338B (de) 1972-03-06 1973-03-06 Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen
GB1075973A GB1379005A (en) 1972-03-06 1973-03-06 2,6-diaminodihydropyridines their production and their medicinal use
FR7307923A FR2181789B1 (ja) 1972-03-06 1973-03-06
CS7500003602A CS182792B2 (en) 1972-03-06 1973-03-06 Method of production of 2,6-diaminodihydropyridines
CS7300001593A CS182781B2 (en) 1972-03-06 1973-03-06 Method of producing 2,6-diaminodihydropyridines
NL7303137A NL7303137A (ja) 1972-03-06 1973-03-06
US05/454,996 US3950336A (en) 1972-03-06 1974-03-27 2,6-diamino-1,4-dihydropyridine derivatives
US455257A US3860601A (en) 1972-03-06 1974-03-27 2,6-diamino-1,4-dihydropyridine derivatives
US454997A US3887558A (en) 1972-03-06 1974-03-27 Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof
US05/455,258 US3957998A (en) 1972-03-06 1974-03-27 Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarboxylic acid esters for effecting coronary vessel dilation and treating hypertension
US05/523,357 US3959474A (en) 1972-03-06 1974-11-13 2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters used as coronary vessel dilators and anti-hypertensive agents
US05/544,837 US4049662A (en) 1972-03-06 1975-01-28 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives
US05/554,135 US4016277A (en) 1972-03-06 1975-02-28 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine
DK365775A DK365775A (ja) 1972-03-06 1975-08-12
JP55185147A JPS5911584B2 (ja) 1972-03-06 1980-12-27 ２，６−ジアミノ−ジヒドロピリジン類の製造法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2210687A DE2210687C3 (de) 1972-03-06 1972-03-06 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
DE2210687A1 DE2210687A1 (de) 1973-09-20
DE2210687B2 DE2210687B2 (de) 1980-09-04
DE2210687C3 true DE2210687C3 (de) 1981-09-24

Family

ID=5838037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2210687A Expired DE2210687C3 (de) 1972-03-06 1972-03-06 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Country Status (24)

Country Link
JP (2) JPS5626659B2 (ja)
KR (1) KR780000119B1 (ja)
AT (3) AT327904B (ja)
BE (1) BE796279A (ja)
BG (2) BG20583A3 (ja)
CA (1) CA988524A (ja)
CH (2) CH577473A5 (ja)
CS (2) CS182781B2 (ja)
DD (1) DD106833A5 (ja)
DE (1) DE2210687C3 (ja)
DK (1) DK136061C (ja)
ES (1) ES412323A1 (ja)
FI (1) FI55996C (ja)
FR (1) FR2181789B1 (ja)
GB (1) GB1379005A (ja)
HU (1) HU167089B (ja)
IE (1) IE37370B1 (ja)
IL (1) IL41664A (ja)
LU (1) LU67147A1 (ja)
NL (1) NL7303137A (ja)
PL (2) PL92078B1 (ja)
RO (2) RO63068A (ja)
SE (1) SE384208B (ja)
ZA (1) ZA731501B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2406198C2 (de) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen
JPS5922593U (ja) * 1982-08-03 1984-02-10 日本マランツ株式会社 ヘツドホ−ン用ホ−ン部取付構造
JPS5922594U (ja) * 1982-08-03 1984-02-10 日本マランツ株式会社 耳栓型ヘツドホ−ン
JPS6282898A (ja) * 1985-10-08 1987-04-16 Matsushita Electric Ind Co Ltd ヘツドホン
JPS6293060U (ja) * 1985-11-28 1987-06-13

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US3855231A (en) * 1972-03-06 1974-12-17 Bayer Ag 2,6-diamino-1,4-dihydropyridine derivatives
DE2406198C2 (de) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen

Also Published As

Publication number Publication date
CA988524A (en) 1976-05-04
DD106833A5 (ja) 1974-07-05
RO61192A (ja) 1976-09-15
JPS5911584B2 (ja) 1984-03-16
GB1379005A (en) 1975-01-02
ZA731501B (en) 1973-11-28
CS182792B2 (en) 1978-05-31
ATA925774A (de) 1975-05-15
DK136061C (da) 1978-01-02
FR2181789A1 (ja) 1973-12-07
CH580589A5 (ja) 1976-10-15
JPS48103579A (ja) 1973-12-25
AT324338B (de) 1975-08-25
PL92078B1 (ja) 1977-03-31
CS182781B2 (en) 1978-05-31
DE2210687B2 (de) 1980-09-04
IL41664A0 (en) 1973-05-31
CH577473A5 (ja) 1976-07-15
NL7303137A (ja) 1973-09-10
IE37370L (en) 1973-09-06
HU167089B (ja) 1975-08-28
JPS5699460A (en) 1981-08-10
BG22815A3 (ja) 1977-04-20
AT327904B (de) 1976-02-25
FI55996B (fi) 1979-07-31
PL89256B1 (ja) 1976-11-30
FR2181789B1 (ja) 1976-12-03
LU67147A1 (ja) 1973-05-22
ES412323A1 (es) 1976-01-01
KR780000119B1 (en) 1978-04-15
DE2210687A1 (de) 1973-09-20
BE796279A (fr) 1973-09-05
FI55996C (fi) 1979-11-12
SE384208B (sv) 1976-04-26
RO63068A (ja) 1978-05-15
BG20583A3 (ja) 1975-12-05
DK136061B (da) 1977-08-08
IL41664A (en) 1976-01-30
JPS5626659B2 (ja) 1981-06-19
IE37370B1 (en) 1977-07-06

Similar Documents

Publication Publication Date Title
EP0002208B1 (de) Nitrosubstituierte 1,4-Dihydropyridine, diese enthaltende Arzneimittel sowie deren Herstellung
EP0026317B1 (de) Optisch aktive 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2218644C3 (de) Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
EP0088274B1 (de) Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE2210672C3 (de) N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117572A1 (de) Unsymmetrische 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel II
DE2210674C3 (de) 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0009206B1 (de) Fluorhaltige 1,4-Dihydropyridine, diese enthaltende Arzneimittel sowie Verfahren zu ihrer Herstellung
DE2210633A1 (de) Neue brueckenkopfheterocyclen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2210667A1 (de) Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0039863B1 (de) 1,4-Dihydropyridine mit unterschiedlichen Substituenten in 2- und 6-Position, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE2210687C3 (de) 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2639257A1 (de) Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2242786A1 (de) Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
DE2239815C2 (de) 2-Alkylamino-dihydropyridine, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP0179386B1 (de) 1,4-Dihydropyridin-hydroxyamine, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln
DE2549568C3 (de) 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE4117750A1 (de) Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3531498A1 (de) Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE2616995A1 (de) 1.4-dihydropyridine mit schwefelhaltigen substituenten mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH635078A5 (de) Verfahren zur herstellung des neuen 1.4-dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsaeure-isopropyl-(2-propoxy-aethyl)-esters.
DE2406198A1 (de) Verfahren zur herstellung von neuen 2-amino-6-dialkylaminodihydropyridinen und ihre verwendung als arzneimittel
DE2242787C2 (de) 4-Phenyl-6-amino-3,4-dihydropyridon-(2)-3,5-dicarbonsäure-diäthylesterderivate, ein Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
EP0042093A2 (de) 4-Aralkyl-1,4-dihydropyridine, Verfahren zu deren Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung
DE2210650C3 (de) 2-Amino-6-alkoxy-4,5-dihydropyridin-3,5-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee