DE2210687C3 - 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel - Google Patents
2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende ArzneimittelInfo
- Publication number
- DE2210687C3 DE2210687C3 DE2210687A DE2210687A DE2210687C3 DE 2210687 C3 DE2210687 C3 DE 2210687C3 DE 2210687 A DE2210687 A DE 2210687A DE 2210687 A DE2210687 A DE 2210687A DE 2210687 C3 DE2210687 C3 DE 2210687C3
- Authority
- DE
- Germany
- Prior art keywords
- diamino
- ooc
- cooc
- ethanol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (41)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2210687A DE2210687C3 (de) | 1972-03-06 | 1972-03-06 | 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
RO73832A RO61192A (el) | 1972-03-06 | 1973-02-13 | |
RO7300082647A RO63068A (el) | 1972-03-06 | 1973-02-13 | |
DD169048A DD106833A5 (el) | 1972-03-06 | 1973-02-26 | |
US00336483A US3855231A (en) | 1972-03-06 | 1973-02-28 | 2,6-diamino-1,4-dihydropyridine derivatives |
BG022858A BG22815A3 (bg) | 1972-03-06 | 1973-02-28 | Метод за получаване на 2,6-диамино-дихидропиридини |
BG024472A BG20583A3 (bg) | 1972-03-06 | 1973-02-28 | Метод за получаване на 2,6-диамино-дихидропиридини |
CH313273A CH580589A5 (el) | 1972-03-06 | 1973-03-02 | |
IL7341664A IL41664A (en) | 1972-03-06 | 1973-03-02 | 2,6-Diamino-dihydropyridines and their pharmaceutical preparations |
CH220176A CH577473A5 (el) | 1972-03-06 | 1973-03-02 | |
LU67147A LU67147A1 (el) | 1972-03-06 | 1973-03-02 | |
FI657/73A FI55996C (fi) | 1972-03-06 | 1973-03-02 | Foerfarande foer framstaellning av 2,6-diamino-dihydropyridiner |
JP2445273A JPS5626659B2 (el) | 1972-03-06 | 1973-03-02 | |
PL1973161010A PL89256B1 (el) | 1972-03-06 | 1973-03-03 | |
PL1973182270A PL92078B1 (el) | 1972-03-06 | 1973-03-03 | |
DK118073A DK136061C (da) | 1972-03-06 | 1973-03-05 | Fremgangsmade til fremstilling af 2,6-diamino-dihydropyridiner |
ES412323A ES412323A1 (es) | 1972-03-06 | 1973-03-05 | Procedimiento para la obtencion de 2,6-diaminodihidropiri- dinas. |
KR7300356A KR780000119B1 (en) | 1972-03-06 | 1973-03-05 | New 2.6-diamino-dihydropyridines, their production, and their medicinal use |
ZA731501A ZA731501B (en) | 1972-03-06 | 1973-03-05 | New 2,6-diamino-dihydropyridines,their production,and their medicinal use |
IE346/73A IE37370B1 (en) | 1972-03-06 | 1973-03-05 | New 2,6-diamino-dihydropyridines their production and their medicinal use |
SE7303021A SE384208B (sv) | 1972-03-06 | 1973-03-05 | Sett att framstella nya 2,6-diamino-dihydropyridiner |
BE128374A BE796279A (fr) | 1972-03-06 | 1973-03-05 | Procede de preparation de nouvelles 2,6-diamino-dihydropyridines |
CA165,209A CA988524A (en) | 1972-03-06 | 1973-03-05 | Process for the preparation of 2,6-diamino-1,4-dihydropyridine derivatives |
AT197373A AT324338B (de) | 1972-03-06 | 1973-03-06 | Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen |
CS7300001593A CS182781B2 (en) | 1972-03-06 | 1973-03-06 | Method of producing 2,6-diaminodihydropyridines |
FR7307923A FR2181789B1 (el) | 1972-03-06 | 1973-03-06 | |
CS7500003602A CS182792B2 (en) | 1972-03-06 | 1973-03-06 | Method of production of 2,6-diaminodihydropyridines |
NL7303137A NL7303137A (el) | 1972-03-06 | 1973-03-06 | |
GB1075973A GB1379005A (en) | 1972-03-06 | 1973-03-06 | 2,6-diaminodihydropyridines their production and their medicinal use |
AT925774A ATA925774A (de) | 1972-03-06 | 1973-03-06 | Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen |
HUBA2892A HU167089B (el) | 1972-03-06 | 1973-03-06 | |
AT925774*7A AT327904B (de) | 1972-03-06 | 1973-03-06 | Verfahren zur herstellung von neuen 2,6-diamino-dihydropyridinen |
US05/454,996 US3950336A (en) | 1972-03-06 | 1974-03-27 | 2,6-diamino-1,4-dihydropyridine derivatives |
US455257A US3860601A (en) | 1972-03-06 | 1974-03-27 | 2,6-diamino-1,4-dihydropyridine derivatives |
US454997A US3887558A (en) | 1972-03-06 | 1974-03-27 | Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof |
US05/455,258 US3957998A (en) | 1972-03-06 | 1974-03-27 | Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarboxylic acid esters for effecting coronary vessel dilation and treating hypertension |
US05/523,357 US3959474A (en) | 1972-03-06 | 1974-11-13 | 2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters used as coronary vessel dilators and anti-hypertensive agents |
US05/544,837 US4049662A (en) | 1972-03-06 | 1975-01-28 | 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives |
US05/554,135 US4016277A (en) | 1972-03-06 | 1975-02-28 | 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine |
DK365775A DK365775A (el) | 1972-03-06 | 1975-08-12 | |
JP55185147A JPS5911584B2 (ja) | 1972-03-06 | 1980-12-27 | 2,6−ジアミノ−ジヒドロピリジン類の製造法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2210687A DE2210687C3 (de) | 1972-03-06 | 1972-03-06 | 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
Publications (3)
Publication Number | Publication Date |
---|---|
DE2210687A1 DE2210687A1 (de) | 1973-09-20 |
DE2210687B2 DE2210687B2 (de) | 1980-09-04 |
DE2210687C3 true DE2210687C3 (de) | 1981-09-24 |
Family
ID=5838037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2210687A Expired DE2210687C3 (de) | 1972-03-06 | 1972-03-06 | 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
Country Status (24)
Country | Link |
---|---|
JP (2) | JPS5626659B2 (el) |
KR (1) | KR780000119B1 (el) |
AT (3) | ATA925774A (el) |
BE (1) | BE796279A (el) |
BG (2) | BG22815A3 (el) |
CA (1) | CA988524A (el) |
CH (2) | CH577473A5 (el) |
CS (2) | CS182781B2 (el) |
DD (1) | DD106833A5 (el) |
DE (1) | DE2210687C3 (el) |
DK (1) | DK136061C (el) |
ES (1) | ES412323A1 (el) |
FI (1) | FI55996C (el) |
FR (1) | FR2181789B1 (el) |
GB (1) | GB1379005A (el) |
HU (1) | HU167089B (el) |
IE (1) | IE37370B1 (el) |
IL (1) | IL41664A (el) |
LU (1) | LU67147A1 (el) |
NL (1) | NL7303137A (el) |
PL (2) | PL92078B1 (el) |
RO (2) | RO63068A (el) |
SE (1) | SE384208B (el) |
ZA (1) | ZA731501B (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2210687C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
DE2406198C2 (de) * | 1974-02-09 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen |
JPS5922594U (ja) * | 1982-08-03 | 1984-02-10 | 日本マランツ株式会社 | 耳栓型ヘツドホ−ン |
JPS5922593U (ja) * | 1982-08-03 | 1984-02-10 | 日本マランツ株式会社 | ヘツドホ−ン用ホ−ン部取付構造 |
JPS6282898A (ja) * | 1985-10-08 | 1987-04-16 | Matsushita Electric Ind Co Ltd | ヘツドホン |
JPS6293060U (el) * | 1985-11-28 | 1987-06-13 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2210687C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
US3855231A (en) * | 1972-03-06 | 1974-12-17 | Bayer Ag | 2,6-diamino-1,4-dihydropyridine derivatives |
DE2406198C2 (de) * | 1974-02-09 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen |
-
1972
- 1972-03-06 DE DE2210687A patent/DE2210687C3/de not_active Expired
-
1973
- 1973-02-13 RO RO7300082647A patent/RO63068A/ro unknown
- 1973-02-13 RO RO73832A patent/RO61192A/ro unknown
- 1973-02-26 DD DD169048A patent/DD106833A5/xx unknown
- 1973-02-28 BG BG022858A patent/BG22815A3/xx unknown
- 1973-02-28 BG BG024472A patent/BG20583A3/xx unknown
- 1973-03-02 CH CH220176A patent/CH577473A5/xx not_active IP Right Cessation
- 1973-03-02 FI FI657/73A patent/FI55996C/fi active
- 1973-03-02 LU LU67147A patent/LU67147A1/xx unknown
- 1973-03-02 CH CH313273A patent/CH580589A5/xx not_active IP Right Cessation
- 1973-03-02 IL IL7341664A patent/IL41664A/en unknown
- 1973-03-02 JP JP2445273A patent/JPS5626659B2/ja not_active Expired
- 1973-03-03 PL PL1973182270A patent/PL92078B1/pl unknown
- 1973-03-03 PL PL1973161010A patent/PL89256B1/pl unknown
- 1973-03-05 DK DK118073A patent/DK136061C/da active
- 1973-03-05 IE IE346/73A patent/IE37370B1/xx unknown
- 1973-03-05 KR KR7300356A patent/KR780000119B1/ko active
- 1973-03-05 BE BE128374A patent/BE796279A/xx not_active IP Right Cessation
- 1973-03-05 SE SE7303021A patent/SE384208B/xx unknown
- 1973-03-05 CA CA165,209A patent/CA988524A/en not_active Expired
- 1973-03-05 ES ES412323A patent/ES412323A1/es not_active Expired
- 1973-03-05 ZA ZA731501A patent/ZA731501B/xx unknown
- 1973-03-06 HU HUBA2892A patent/HU167089B/hu unknown
- 1973-03-06 AT AT925774A patent/ATA925774A/de unknown
- 1973-03-06 AT AT197373A patent/AT324338B/de not_active IP Right Cessation
- 1973-03-06 FR FR7307923A patent/FR2181789B1/fr not_active Expired
- 1973-03-06 CS CS7300001593A patent/CS182781B2/cs unknown
- 1973-03-06 NL NL7303137A patent/NL7303137A/xx not_active Application Discontinuation
- 1973-03-06 GB GB1075973A patent/GB1379005A/en not_active Expired
- 1973-03-06 CS CS7500003602A patent/CS182792B2/cs unknown
- 1973-03-06 AT AT925774*7A patent/AT327904B/de not_active IP Right Cessation
-
1980
- 1980-12-27 JP JP55185147A patent/JPS5911584B2/ja not_active Expired
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