DE2210262A1 - Polyvalente proteaseninhibitorpraeparate aus helix pomatia - Google Patents
Polyvalente proteaseninhibitorpraeparate aus helix pomatiaInfo
- Publication number
- DE2210262A1 DE2210262A1 DE2210262A DE2210262A DE2210262A1 DE 2210262 A1 DE2210262 A1 DE 2210262A1 DE 2210262 A DE2210262 A DE 2210262A DE 2210262 A DE2210262 A DE 2210262A DE 2210262 A1 DE2210262 A1 DE 2210262A1
- Authority
- DE
- Germany
- Prior art keywords
- content
- preparations
- amino acid
- preparations according
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 18
- 241000237369 Helix pomatia Species 0.000 title claims description 12
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title claims description 5
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 title claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 29
- 108090000631 Trypsin Proteins 0.000 claims description 14
- 102000004142 Trypsin Human genes 0.000 claims description 14
- 239000012588 trypsin Substances 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 108060005987 Kallikrein Proteins 0.000 claims description 6
- 102000001399 Kallikrein Human genes 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 108090000317 Chymotrypsin Proteins 0.000 claims description 5
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 5
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 5
- 229960002376 chymotrypsin Drugs 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 4
- 108010088842 Fibrinolysin Proteins 0.000 claims description 3
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 3
- 229940012957 plasmin Drugs 0.000 claims description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 229960001322 trypsin Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000001166 ammonium sulphate Substances 0.000 claims 1
- 230000020764 fibrinolysis Effects 0.000 claims 1
- 229920005654 Sephadex Polymers 0.000 description 14
- 239000012507 Sephadex™ Substances 0.000 description 14
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 description 12
- 229940068628 helicin Drugs 0.000 description 12
- BGOFCVIGEYGEOF-UHFFFAOYSA-N salicylaldehyde beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UHFFFAOYSA-N 0.000 description 12
- 230000005764 inhibitory process Effects 0.000 description 10
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 208000034158 bleeding Diseases 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 210000004907 gland Anatomy 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000010828 elution Methods 0.000 description 5
- 239000004365 Protease Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000237858 Gastropoda Species 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 108090000526 Papain Proteins 0.000 description 2
- 206010051077 Post procedural haemorrhage Diseases 0.000 description 2
- 108010059712 Pronase Proteins 0.000 description 2
- 108090001109 Thermolysin Proteins 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 229940122618 Trypsin inhibitor Drugs 0.000 description 2
- 101710162629 Trypsin inhibitor Proteins 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000000988 hyperfibrinolytic effect Effects 0.000 description 2
- 238000000760 immunoelectrophoresis Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940055729 papain Drugs 0.000 description 2
- 235000019834 papain Nutrition 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 239000002753 trypsin inhibitor Substances 0.000 description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 108010019393 Fibrin Foam Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033647 Pancreatitis acute Diseases 0.000 description 1
- 240000005546 Piper methysticum Species 0.000 description 1
- 235000016787 Piper methysticum Nutrition 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000003229 acute pancreatitis Diseases 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- YQDHCCVUYCIGSW-LBPRGKRZSA-N ethyl (2s)-2-benzamido-5-(diaminomethylideneamino)pentanoate Chemical compound NC(=N)NCCC[C@@H](C(=O)OCC)NC(=O)C1=CC=CC=C1 YQDHCCVUYCIGSW-LBPRGKRZSA-N 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000004086 maxillary sinus Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- -1 sulfoethyl Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2210262A DE2210262A1 (de) | 1972-03-03 | 1972-03-03 | Polyvalente proteaseninhibitorpraeparate aus helix pomatia |
| JP48023828A JPS4899384A (forum.php) | 1972-03-03 | 1973-03-01 | |
| US337699A US3885012A (en) | 1972-03-03 | 1973-03-02 | New protease-inhibiting substance, its extraction, and its use |
| FR7307515A FR2174925B1 (forum.php) | 1972-03-03 | 1973-03-02 | |
| GB1024273A GB1378277A (en) | 1972-03-03 | 1973-03-02 | Proteaseinhibiting substance its extraction and its use |
| CH313873A CH590063A5 (forum.php) | 1972-03-03 | 1973-03-02 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2210262A DE2210262A1 (de) | 1972-03-03 | 1972-03-03 | Polyvalente proteaseninhibitorpraeparate aus helix pomatia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2210262A1 true DE2210262A1 (de) | 1973-09-06 |
Family
ID=5837811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2210262A Pending DE2210262A1 (de) | 1972-03-03 | 1972-03-03 | Polyvalente proteaseninhibitorpraeparate aus helix pomatia |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3885012A (forum.php) |
| JP (1) | JPS4899384A (forum.php) |
| CH (1) | CH590063A5 (forum.php) |
| DE (1) | DE2210262A1 (forum.php) |
| FR (1) | FR2174925B1 (forum.php) |
| GB (1) | GB1378277A (forum.php) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971736A (en) * | 1975-01-21 | 1976-07-27 | Merck & Co., Inc. | Cathepsin in D inhibitors |
| ES2108110T3 (es) * | 1991-03-01 | 1997-12-16 | Atherton Investments Ltd | Composiciones terapeuticas y cosmeticas para el tratamiento de la piel. |
| FR3023717B1 (fr) * | 2014-07-21 | 2017-12-08 | Pascal Drevet | Hydrolysat peptidique d'escargots, fractions peptidiques, procede de fabrication, utilisation et compositions pour inhiber l'enzyme de conversion de l'angiotensine |
-
1972
- 1972-03-03 DE DE2210262A patent/DE2210262A1/de active Pending
-
1973
- 1973-03-01 JP JP48023828A patent/JPS4899384A/ja active Pending
- 1973-03-02 CH CH313873A patent/CH590063A5/xx not_active IP Right Cessation
- 1973-03-02 GB GB1024273A patent/GB1378277A/en not_active Expired
- 1973-03-02 US US337699A patent/US3885012A/en not_active Expired - Lifetime
- 1973-03-02 FR FR7307515A patent/FR2174925B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH590063A5 (forum.php) | 1977-07-29 |
| JPS4899384A (forum.php) | 1973-12-15 |
| FR2174925B1 (forum.php) | 1976-12-03 |
| FR2174925A1 (forum.php) | 1973-10-19 |
| GB1378277A (en) | 1974-12-27 |
| US3885012A (en) | 1975-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OHN | Withdrawal |