DE2163791C2 - Verfahren zur Herstellung von 7-Amino-3-methyl-3-cephem-4-carbonsäure und ihrer Ester - Google Patents

Verfahren zur Herstellung von 7-Amino-3-methyl-3-cephem-4-carbonsäure und ihrer Ester

Info

Publication number
DE2163791C2
DE2163791C2 DE2163791A DE2163791A DE2163791C2 DE 2163791 C2 DE2163791 C2 DE 2163791C2 DE 2163791 A DE2163791 A DE 2163791A DE 2163791 A DE2163791 A DE 2163791A DE 2163791 C2 DE2163791 C2 DE 2163791C2
Authority
DE
Germany
Prior art keywords
methyl
cephem
carboxylic acid
ifo
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2163791A
Other languages
German (de)
English (en)
Other versions
DE2163791A1 (de
Inventor
Masao Hyogo Isono
Kenji Osaka Kawahara
Takeshi Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE2163791A1 publication Critical patent/DE2163791A1/de
Application granted granted Critical
Publication of DE2163791C2 publication Critical patent/DE2163791C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/929—Fusarium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2163791A 1970-12-25 1971-12-22 Verfahren zur Herstellung von 7-Amino-3-methyl-3-cephem-4-carbonsäure und ihrer Ester Expired DE2163791C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP45129648A JPS4948760B1 (cs) 1970-12-25 1970-12-25

Publications (2)

Publication Number Publication Date
DE2163791A1 DE2163791A1 (de) 1972-07-20
DE2163791C2 true DE2163791C2 (de) 1985-02-21

Family

ID=15014700

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2163791A Expired DE2163791C2 (de) 1970-12-25 1971-12-22 Verfahren zur Herstellung von 7-Amino-3-methyl-3-cephem-4-carbonsäure und ihrer Ester

Country Status (13)

Country Link
US (1) US3749641A (cs)
JP (1) JPS4948760B1 (cs)
AT (1) AT320144B (cs)
AU (1) AU467458B2 (cs)
BE (1) BE777261A (cs)
CA (1) CA1013692A (cs)
CH (1) CH565186A5 (cs)
DE (1) DE2163791C2 (cs)
FR (1) FR2120839A5 (cs)
GB (1) GB1377379A (cs)
HU (1) HU166646B (cs)
NL (1) NL175642C (cs)
SE (1) SE402123B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5341232B2 (cs) * 1972-06-17 1978-11-01
US4059573A (en) * 1973-08-01 1977-11-22 Glaxo Laboratories Limited Extraction of N-blocked amino acids from aqueous media
JPS5417032B2 (cs) * 1974-01-23 1979-06-27
US4001600A (en) * 1975-06-02 1977-01-04 Watkins-Johnson Company Interconnecting circuit for ebs diodes and method
US3972774A (en) * 1975-07-28 1976-08-03 Eli Lilly And Company Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters
JPS52143289A (en) * 1976-05-24 1977-11-29 Meiji Seika Kaisha Ltd Production of 7-amino-cephem derivatives by filamentous fungi
US4230799A (en) * 1977-02-09 1980-10-28 Schering Corporation Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
US4316958A (en) * 1979-02-10 1982-02-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing optically active cephalosporin analogs
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
US4316955A (en) * 1980-11-10 1982-02-23 Eli Lilly And Company Enzymatic deesterification of cephalosporin methyl esters
US4618583A (en) * 1984-11-19 1986-10-21 E. R. Squibb & Sons, Inc. Method of preparing L-(+)-β-hydroxyisobutyric acid by fermentation
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
US5229274A (en) * 1989-06-27 1993-07-20 Merck & Co., Inc. Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
GB9216759D0 (en) * 1992-08-07 1992-09-23 Finpael Spa Process for the production of 7-amino thiazolyl cephalosporins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD74282A (cs) *
FR1357977A (fr) * 1963-05-20 1964-04-10 Merck & Co Inc Procédé de production d'acide 7-aminocéphalosphalosporanique par voie enzymatique
US3284451A (en) * 1965-07-22 1966-11-08 Bristol Myers Co Activated esters of 7-amino-cephalosporanic acid
NL150798B (nl) * 1967-08-07 1976-09-15 Koninklijke Gist Spiritus Werkwijze voor de bereiding van 7-aminocefalosoranzuur en derivaten daarvan.
US3522250A (en) * 1968-10-15 1970-07-28 American Home Prod Derivatives of 7-aminocephalosporanic acid

Also Published As

Publication number Publication date
AT320144B (de) 1975-01-27
FR2120839A5 (cs) 1972-08-18
JPS4948760B1 (cs) 1974-12-23
NL7117696A (cs) 1972-06-27
NL175642C (nl) 1984-12-03
US3749641A (en) 1973-07-31
DE2163791A1 (de) 1972-07-20
HU166646B (cs) 1975-04-28
CH565186A5 (cs) 1975-08-15
SE402123B (sv) 1978-06-19
AU467458B2 (en) 1975-12-04
CA1013692A (en) 1977-07-12
BE777261A (fr) 1972-04-17
NL175642B (nl) 1984-07-02
GB1377379A (en) 1974-12-11
AU3737171A (en) 1973-06-28

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Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition