DE2150819A1 - Verfahren zur Reinigung konjugierter OEstrogene - Google Patents
Verfahren zur Reinigung konjugierter OEstrogeneInfo
- Publication number
- DE2150819A1 DE2150819A1 DE19712150819 DE2150819A DE2150819A1 DE 2150819 A1 DE2150819 A1 DE 2150819A1 DE 19712150819 DE19712150819 DE 19712150819 DE 2150819 A DE2150819 A DE 2150819A DE 2150819 A1 DE2150819 A1 DE 2150819A1
- Authority
- DE
- Germany
- Prior art keywords
- aqueous
- resin
- chloride solution
- sodium chloride
- estrogenic substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940035811 conjugated estrogen Drugs 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 48
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
- 239000011347 resin Substances 0.000 claims description 40
- 229920005989 resin Polymers 0.000 claims description 40
- 239000000243 solution Substances 0.000 claims description 40
- 239000011780 sodium chloride Substances 0.000 claims description 24
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 18
- 239000002156 adsorbate Substances 0.000 claims description 13
- 239000003957 anion exchange resin Substances 0.000 claims description 13
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 13
- 230000001476 alcoholic effect Effects 0.000 claims description 10
- 210000002700 urine Anatomy 0.000 claims description 10
- 235000019270 ammonium chloride Nutrition 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- VUCAHVBMSFIGAI-ZFINNJDLSA-M estrone sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 VUCAHVBMSFIGAI-ZFINNJDLSA-M 0.000 claims description 6
- 229960000747 sodium estrone sulfate Drugs 0.000 claims description 6
- JKKFKPJIXZFSSB-UHFFFAOYSA-N 1,3,5(10)-estratrien-17-one 3-sulfate Natural products OS(=O)(=O)OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 JKKFKPJIXZFSSB-UHFFFAOYSA-N 0.000 claims description 5
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 2
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 14
- 239000012156 elution solvent Substances 0.000 claims 6
- 239000003480 eluent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 description 4
- 230000001076 estrogenic effect Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920000768 polyamine Polymers 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 229920001268 Cholestyramine Polymers 0.000 description 1
- 102100033070 Histone acetyltransferase KAT6B Human genes 0.000 description 1
- 101000944174 Homo sapiens Histone acetyltransferase KAT6B Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100035591 POU domain, class 2, transcription factor 2 Human genes 0.000 description 1
- 101710084411 POU domain, class 2, transcription factor 2 Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- YOUGRGFIHBUKRS-UHFFFAOYSA-N benzyl(trimethyl)azanium Chemical compound C[N+](C)(C)CC1=CC=CC=C1 YOUGRGFIHBUKRS-UHFFFAOYSA-N 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229940107170 cholestyramine resin Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 229940073095 questran Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
- B01J41/05—Processes using organic exchangers in the strongly basic form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8049170A | 1970-10-13 | 1970-10-13 | |
| US9120070A | 1970-11-19 | 1970-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2150819A1 true DE2150819A1 (de) | 1972-04-20 |
Family
ID=26763589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712150819 Pending DE2150819A1 (de) | 1970-10-13 | 1971-10-12 | Verfahren zur Reinigung konjugierter OEstrogene |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA954123A (enExample) |
| CH (1) | CH601343A5 (enExample) |
| DE (1) | DE2150819A1 (enExample) |
| FR (1) | FR2111261A5 (enExample) |
| GB (1) | GB1371052A (enExample) |
| NL (1) | NL7111863A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998008526A1 (de) * | 1996-08-30 | 1998-03-05 | Solvay Deutschland Gmbh | Verfahren zur gewinnung von oestrogenen aus stutenharn |
| US7074325B2 (en) | 2000-08-01 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Device for concentrating and stabilizing conjugated estrogens from mare urine |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU9500323D0 (en) * | 1994-02-08 | 1995-03-28 | Solvay Deutschland | Process for separating estrogenes from urine of mares with foal |
-
1971
- 1971-08-27 NL NL7111863A patent/NL7111863A/xx not_active Application Discontinuation
- 1971-10-04 GB GB4609071A patent/GB1371052A/en not_active Expired
- 1971-10-04 CA CA124,376A patent/CA954123A/en not_active Expired
- 1971-10-12 FR FR7136602A patent/FR2111261A5/fr not_active Expired
- 1971-10-12 DE DE19712150819 patent/DE2150819A1/de active Pending
- 1971-10-13 CH CH1492871A patent/CH601343A5/xx not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998008526A1 (de) * | 1996-08-30 | 1998-03-05 | Solvay Deutschland Gmbh | Verfahren zur gewinnung von oestrogenen aus stutenharn |
| CZ298761B6 (cs) * | 1996-08-30 | 2008-01-23 | Solvay Pharmaceuticals Gmbh | Postup získávání estrogenů z moči klisen |
| US7074325B2 (en) | 2000-08-01 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Device for concentrating and stabilizing conjugated estrogens from mare urine |
| US7081451B2 (en) | 2000-08-01 | 2006-07-25 | Solvay Pharmaceuticals Gmbh | Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine |
| US7524833B2 (en) | 2000-08-01 | 2009-04-28 | Solvay Pharmaceuticals Gmbh | Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine |
Also Published As
| Publication number | Publication date |
|---|---|
| CH601343A5 (enExample) | 1978-07-14 |
| FR2111261A5 (enExample) | 1972-06-02 |
| GB1371052A (en) | 1974-10-23 |
| CA954123A (en) | 1974-09-03 |
| NL7111863A (enExample) | 1972-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |